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Erschienen in:
01.08.2005 | Short Report
Impact of increased D-dimer concentrations in Kawasaki disease
Erschienen in: European Journal of Pediatrics | Ausgabe 8/2005
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Increased D-dimer concentrations are a useful clinical marker to diagnose Kawasaki disease (KD). KD is associated with widespread vascular endothelial damage [2]. Thus, markers related to endothelial damage might be useful for the early and accurate diagnosis of KD [4,6]. Elevation of D-dimer was reported to be associated with some cases of systemic vasculitis [1,3] and was also previously reported to be increased in the acute phase of KD [5]; however, it has not yet been evaluated extensively. We therefore evaluated haemostatic markers in 11 KD patients diagnosed consecutively in our institute from September 2003 to June 2004. A total of 12 febrile patients referred to our hospital from January 2004 to June 2004 were included as controls (Table 1).
Table 1
Patients’ characteristics and laboratory findings. Data are given as median and range. The Mann-Whitney U test was used for between-group comparisons. A level of P <0.05 was accepted as significant
|
|
KDa
|
Controlb
|
P
|
|---|---|---|---|
|
N
|
11
|
12
|
|
|
Male/female
|
7/4
|
8/4
|
0.88
|
|
Age (years)
|
3.0 (0.7–6)
|
4.0 (1.0–6)
|
0.21
|
|
WBC (/μl)
|
13,900 (4,500–23,300)
|
11,550 (3,200–24,000)
|
0.32
|
|
Platelets (×104/μl)
|
34.3 (20.9–51.7)
|
29.45 (25.6–68.1)
|
0.52
|
|
CRP (mg/dl)
|
8.20 (0.8–16.5)
|
3.55 (0.6–21.5)
|
0.23
|
|
Fibrinogen (mg/dl)
|
673 (348–1055)
|
496 (367–692)
|
0.09
|
|
D-dimer (μg/ml)
|
1.87 (0.93–5.24)
|
0.75 (0.31–5.69) c
|
0.001
|