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Erschienen in: European Journal of Pediatrics 4/2009

01.04.2009 | Review

Congenital diaphragmatic hernia: current status and review of the literature

verfasst von: Anthony S. de Buys Roessingh, Anh Tuan Dinh-Xuan

Erschienen in: European Journal of Pediatrics | Ausgabe 4/2009

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Abstract

Treatment of congenital diaphragmatic hernia (CDH) challenges obstetricians, pediatric surgeons, and neonatologists. Persistent pulmonary hypertension (PPHT) associated with lung hypoplasia in CDH leads to a high mortality rate at birth. PPHT is principally due to an increased muscularization of the arterioles. Management of CDH has been greatly improved by the introduction of prenatal surgical intervention with tracheal obstruction (TO) and by more appropriate postnatal care. TO appears to accelerate fetal lung growth and to increase the number of capillary vessels and alveoli. Improvement of postnatal care over the last years is mainly due to the avoidance of lung injury by applying low peak inflation pressure during ventilation. The benefits of other drugs or technical improvements such as the use of inhaled nitric oxide or extracorporeal membrane oxygenation (ECMO) are still being debated and no single strategy is accepted worldwide. Despite intensive clinical and experimental research, the treatment of newborn with CDH remains difficult.
Literatur
4.
Zurück zum Zitat Bernbaum J, Schwartz IP, Gerdes M, D'Agostino JA, Coburn CE, Polin RA (1995) Survivors of extracorporeal membrane oxygenation at 1 year of age: the relationship of primary diagnosis with health and neurodevelopmental sequelae. Pediatrics 96:907–913PubMed Bernbaum J, Schwartz IP, Gerdes M, D'Agostino JA, Coburn CE, Polin RA (1995) Survivors of extracorporeal membrane oxygenation at 1 year of age: the relationship of primary diagnosis with health and neurodevelopmental sequelae. Pediatrics 96:907–913PubMed
5.
Zurück zum Zitat Bhuta T, Clark RH, Henderson-Smart DJ (2001) Rescue high frequency oscillatory ventilation vs conventionnal ventilation for infants with severe pulmonary dysfunction born at near term. Cochrane Database Syst Rev 1:CDOO2974 Bhuta T, Clark RH, Henderson-Smart DJ (2001) Rescue high frequency oscillatory ventilation vs conventionnal ventilation for infants with severe pulmonary dysfunction born at near term. Cochrane Database Syst Rev 1:CDOO2974
9.
Zurück zum Zitat Calkovská A, Javorka K, Petrásková M, Laucoková-Misíková I, Drgová A, Gál M (1997) Changes in mechanisms of breathing during high-frequency jet ventilation: what is the cause? Physiol Res 46:271–278PubMed Calkovská A, Javorka K, Petrásková M, Laucoková-Misíková I, Drgová A, Gál M (1997) Changes in mechanisms of breathing during high-frequency jet ventilation: what is the cause? Physiol Res 46:271–278PubMed
11.
Zurück zum Zitat Cloutier M, Seaborn T, Piedboeuf B, Bratu I, Flageole H, Laberge JM (2005) Effect of temporary tracheal occlusion on the endothelin system in experimental cases of diaphragmatic hernia. Exp Lung Res 31:391–404. doi:10.1080/019021490927079 PubMedCrossRef Cloutier M, Seaborn T, Piedboeuf B, Bratu I, Flageole H, Laberge JM (2005) Effect of temporary tracheal occlusion on the endothelin system in experimental cases of diaphragmatic hernia. Exp Lung Res 31:391–404. doi:10.​1080/​019021490927079 PubMedCrossRef
14.
Zurück zum Zitat Coleman BG, Adzick NS, Crombleholme TM (2002) Fetal therapy: state of the art. J Ultrasound Med 21:1257–1288PubMed Coleman BG, Adzick NS, Crombleholme TM (2002) Fetal therapy: state of the art. J Ultrasound Med 21:1257–1288PubMed
17.
Zurück zum Zitat Davidson D (1998) Pulmonary hemodynamics at birth: effect of acute cyclooxygenase inhibition in lambs. J Appl Physiol 64:1676–1682 Davidson D (1998) Pulmonary hemodynamics at birth: effect of acute cyclooxygenase inhibition in lambs. J Appl Physiol 64:1676–1682
18.
21.
Zurück zum Zitat Deprest J, Gratacos E, Nicolaides KH (2004) Fetoscopic tracheal occlusion (FETO) for severe congenital diaphragmatic hernia: evolution of a technique and preliminary results. Ultrasound Gynecol 24:121–126. doi:10.1002/uog.1711 CrossRef Deprest J, Gratacos E, Nicolaides KH (2004) Fetoscopic tracheal occlusion (FETO) for severe congenital diaphragmatic hernia: evolution of a technique and preliminary results. Ultrasound Gynecol 24:121–126. doi:10.​1002/​uog.​1711 CrossRef
22.
Zurück zum Zitat Desfrère L, Jarreau PH, Dommergues M (2000) Impact of delayed repair and elective high-frequency oscillatory ventilation on survival of antenatally diagnosed congenital diaphragmatic hernia: first application of these strategies in the more severe subgroup of antenatally diagnosed newborns. Intensive Care Med 26:934–941. doi:10.1007/s001340051284 PubMedCrossRef Desfrère L, Jarreau PH, Dommergues M (2000) Impact of delayed repair and elective high-frequency oscillatory ventilation on survival of antenatally diagnosed congenital diaphragmatic hernia: first application of these strategies in the more severe subgroup of antenatally diagnosed newborns. Intensive Care Med 26:934–941. doi:10.​1007/​s001340051284 PubMedCrossRef
24.
Zurück zum Zitat Elbourne D, Field D, Mugford M (2002) Extracorporeal membrane oxygenation for severe respiratory failure in newborn infants. Cochrane Database Syst Rev 1:CDOO1340 Elbourne D, Field D, Mugford M (2002) Extracorporeal membrane oxygenation for severe respiratory failure in newborn infants. Cochrane Database Syst Rev 1:CDOO1340
26.
Zurück zum Zitat Fasching G, Huber A, Uray E, Sorantin E, Lindbichler F, Mayr J (2000) Gastroesophageal reflux and diaphragmatic motility after repair of congenital diaphragmatic hernia. Eur J Pediatr Surg 10:360–364PubMed Fasching G, Huber A, Uray E, Sorantin E, Lindbichler F, Mayr J (2000) Gastroesophageal reflux and diaphragmatic motility after repair of congenital diaphragmatic hernia. Eur J Pediatr Surg 10:360–364PubMed
29.
Zurück zum Zitat Finer NN, Barrington KJ (2001) Nitric oxide for respiratory failure in infants born at a near term. Cochrane Database Syst Rev 4:CDOO399 Finer NN, Barrington KJ (2001) Nitric oxide for respiratory failure in infants born at a near term. Cochrane Database Syst Rev 4:CDOO399
30.
Zurück zum Zitat Flake A, Crombleholme T, Johnson M, Howell LJ, Adzick NS (2000) Treatment of severe congenital diaphragmatic hernia by fetal tracheal occlusion: clinical experience with fifteen cases. Am J Obstet Gynecol 183:1059–1066. doi:10.1067/mob.2000.108871 PubMedCrossRef Flake A, Crombleholme T, Johnson M, Howell LJ, Adzick NS (2000) Treatment of severe congenital diaphragmatic hernia by fetal tracheal occlusion: clinical experience with fifteen cases. Am J Obstet Gynecol 183:1059–1066. doi:10.​1067/​mob.​2000.​108871 PubMedCrossRef
31.
Zurück zum Zitat Fligor BJ, Neault MW, Mullen CH, Feldman HA, Jones DT (2005) Factors associated with sensorineural hearing loss among survivors of extracorporeal membrane oxygenation therapy. Pediatrics 115:1519–1528. doi:10.1542/peds.2004-0247 PubMedCrossRef Fligor BJ, Neault MW, Mullen CH, Feldman HA, Jones DT (2005) Factors associated with sensorineural hearing loss among survivors of extracorporeal membrane oxygenation therapy. Pediatrics 115:1519–1528. doi:10.​1542/​peds.​2004-0247 PubMedCrossRef
32.
34.
Zurück zum Zitat Geggel RL, Murphy JD, Langleben D, Crone RK, Vacanti JP, Reid LM (1985) Congenital diaphragmatic hernia: arterial structural changes and persistent pulmonary hypertension after surgical repair. J Pediatr 107:457–464. doi:10.1016/S0022-3476(85)80534-5 PubMedCrossRef Geggel RL, Murphy JD, Langleben D, Crone RK, Vacanti JP, Reid LM (1985) Congenital diaphragmatic hernia: arterial structural changes and persistent pulmonary hypertension after surgical repair. J Pediatr 107:457–464. doi:10.​1016/​S0022-3476(85)80534-5 PubMedCrossRef
36.
Zurück zum Zitat Greer JJ, Cote D, Allan DW (2000) Structure of the primordial diaphragm and defects associated with nitrofen-induced CDH. J Appl Physiol 89:2123–2129PubMed Greer JJ, Cote D, Allan DW (2000) Structure of the primordial diaphragm and defects associated with nitrofen-induced CDH. J Appl Physiol 89:2123–2129PubMed
38.
Zurück zum Zitat Harrison MR, Adzick NS, Longaker MT (1990) Successful repair in utero of fetal diaphragmatic hernia after removal of herniated viscera from the left thorax. N Engl J Med 322:1582–1584PubMed Harrison MR, Adzick NS, Longaker MT (1990) Successful repair in utero of fetal diaphragmatic hernia after removal of herniated viscera from the left thorax. N Engl J Med 322:1582–1584PubMed
40.
Zurück zum Zitat Harrison MR, Mychaliska GB, Albanese CT (1998) Correction of congenital diaphragmatic hernia in utero IX: fetuses with poor prognosis can be saved by fetoscopic temporary tracheal occlusion. J Pediatr Surg 33:1017–1022. doi:10.1016/S0022-3468(98)90524-3 PubMedCrossRef Harrison MR, Mychaliska GB, Albanese CT (1998) Correction of congenital diaphragmatic hernia in utero IX: fetuses with poor prognosis can be saved by fetoscopic temporary tracheal occlusion. J Pediatr Surg 33:1017–1022. doi:10.​1016/​S0022-3468(98)90524-3 PubMedCrossRef
41.
Zurück zum Zitat Harrison MR, Keller RL, Hawgood SB (2003) A randomized trial of fetal endoscopic tracheal occlusion for severe fetal congenital diaphragmatic hernia. N Engl J Med 349:1916–1924. doi:10.1056/NEJMoa035005 PubMedCrossRef Harrison MR, Keller RL, Hawgood SB (2003) A randomized trial of fetal endoscopic tracheal occlusion for severe fetal congenital diaphragmatic hernia. N Engl J Med 349:1916–1924. doi:10.​1056/​NEJMoa035005 PubMedCrossRef
50.
Zurück zum Zitat Kanai M, Kitano Y, von Allmen D, Davies P, Adzick NS, Flake AW (2001) Fetal tracheal occlusion in the rat model of nitrofen-induced congenital diaphragmatic hernia: tracheal occlusion reverses the arterial structural abnormality. J Pediatr Surg 36:839–845. doi:10.1053/jpsu.2001.23950 PubMedCrossRef Kanai M, Kitano Y, von Allmen D, Davies P, Adzick NS, Flake AW (2001) Fetal tracheal occlusion in the rat model of nitrofen-induced congenital diaphragmatic hernia: tracheal occlusion reverses the arterial structural abnormality. J Pediatr Surg 36:839–845. doi:10.​1053/​jpsu.​2001.​23950 PubMedCrossRef
51.
Zurück zum Zitat Karamanoukian HL, Glick PL, Wilcox DT (1995) Pathophysiology of congenital diaphragmatic hernia XI: anatomic and biochemical characterization of the heart in the fetal lamb CDH model. J Pediatr Surg 30:925–929. doi:10.1016/0022-3468(95)90314-3 PubMedCrossRef Karamanoukian HL, Glick PL, Wilcox DT (1995) Pathophysiology of congenital diaphragmatic hernia XI: anatomic and biochemical characterization of the heart in the fetal lamb CDH model. J Pediatr Surg 30:925–929. doi:10.​1016/​0022-3468(95)90314-3 PubMedCrossRef
52.
54.
55.
Zurück zum Zitat Kluth D, Keijzer R, Hertl M, Tibboel D (1996) Embryology of congenital diaphragmatic hernia. Semin Pediatr Surg 4:224–233 Kluth D, Keijzer R, Hertl M, Tibboel D (1996) Embryology of congenital diaphragmatic hernia. Semin Pediatr Surg 4:224–233
56.
58.
Zurück zum Zitat Langham MR, Kays DW, Ledbetter DJ, Frentzen B, Sanford LL, Richards DS (1996) Congenital diaphragmatic hernia: epidemiology and outcome. Clin Perinatol 23:671–688PubMed Langham MR, Kays DW, Ledbetter DJ, Frentzen B, Sanford LL, Richards DS (1996) Congenital diaphragmatic hernia: epidemiology and outcome. Clin Perinatol 23:671–688PubMed
59.
Zurück zum Zitat Laudy JA, Van Gucht M, Van Dooren MF, Wladimiroff JW, Tibboel D (2003) Congenital diaphragmatic hernia: an evaluation of the prognostic value of the lung-to-head ratio and other prenatal parameters. Prenat Diagn 23:634–639. doi:10.1002/pd.654 PubMedCrossRef Laudy JA, Van Gucht M, Van Dooren MF, Wladimiroff JW, Tibboel D (2003) Congenital diaphragmatic hernia: an evaluation of the prognostic value of the lung-to-head ratio and other prenatal parameters. Prenat Diagn 23:634–639. doi:10.​1002/​pd.​654 PubMedCrossRef
60.
62.
68.
Zurück zum Zitat Morin FC III, Stenmark KR (1995) Persistent pulmonary hypertension of the newborn. Am J Respir Crit Care Med 151:2010–2035PubMed Morin FC III, Stenmark KR (1995) Persistent pulmonary hypertension of the newborn. Am J Respir Crit Care Med 151:2010–2035PubMed
71.
Zurück zum Zitat Moyer V, Moya F, Tibboel R, Losty P, Nagaya M, Lally KP (2002) Late versus early surgical correction for congenital diaphragmatic hernia in newborn infants. Cochrane Database Syst Rev 3:CD001695PubMed Moyer V, Moya F, Tibboel R, Losty P, Nagaya M, Lally KP (2002) Late versus early surgical correction for congenital diaphragmatic hernia in newborn infants. Cochrane Database Syst Rev 3:CD001695PubMed
72.
Zurück zum Zitat Muratore CS, Kharasch V, Lund DP (2001) Pulmonary morbidity in 100 survivors of congenital diaphragmatic hernia monitored in a multidisciplinary clinic. J Pediatr Surg 30:133–140. doi:10.1053/jpsu.2001.20031 CrossRef Muratore CS, Kharasch V, Lund DP (2001) Pulmonary morbidity in 100 survivors of congenital diaphragmatic hernia monitored in a multidisciplinary clinic. J Pediatr Surg 30:133–140. doi:10.​1053/​jpsu.​2001.​20031 CrossRef
75.
Zurück zum Zitat Ovadia B, Bekker JM, Fitzgerald R, Kon A, Thelitz S, Johengen MJ, Hendricks Munoz K, Gerrets R, Black SM, Fineman JR (2002) Nitric oxide endothelin 1 interactions after ductal constriction in fetal lambs. Am J Physiol Heart Circ Physiol 284:H480–H490PubMed Ovadia B, Bekker JM, Fitzgerald R, Kon A, Thelitz S, Johengen MJ, Hendricks Munoz K, Gerrets R, Black SM, Fineman JR (2002) Nitric oxide endothelin 1 interactions after ductal constriction in fetal lambs. Am J Physiol Heart Circ Physiol 284:H480–H490PubMed
78.
Zurück zum Zitat Rasheed A, Tindall S, Cueny DL, Klein MD, Delaney-Black V (2001) Neurodevelopmental outcome after congenital diaphragmatic hernia: extracorporeal membrane oxygenation before and after surgery. J Pediatr Surg 36:539–544. doi:10.1053/jpsu.2001.22278 PubMedCrossRef Rasheed A, Tindall S, Cueny DL, Klein MD, Delaney-Black V (2001) Neurodevelopmental outcome after congenital diaphragmatic hernia: extracorporeal membrane oxygenation before and after surgery. J Pediatr Surg 36:539–544. doi:10.​1053/​jpsu.​2001.​22278 PubMedCrossRef
80.
Zurück zum Zitat Ruano R, Aubry MC, Barthe B, Mitanchez D, Dumez Y, Benachi A (2006) Quantitative analysis of fetal pulmonary vasculature by 3-dimensional power Doppler ultrasonography in isolated congenital diaphragmatic hernia. Am J Obstet Gynecol 195:1720–1728. doi:10.1016/j.ajog.2006.05.010 PubMedCrossRef Ruano R, Aubry MC, Barthe B, Mitanchez D, Dumez Y, Benachi A (2006) Quantitative analysis of fetal pulmonary vasculature by 3-dimensional power Doppler ultrasonography in isolated congenital diaphragmatic hernia. Am J Obstet Gynecol 195:1720–1728. doi:10.​1016/​j.​ajog.​2006.​05.​010 PubMedCrossRef
82.
Zurück zum Zitat Saqueton CB, Miller RB, Porter VA, Milla CE, Cornfield DN (1996) NO causes perinatal pulmonary vasodilation though K+ channel activation and intracellular Ca2+ release. Am J Physiol 276:925–932 Saqueton CB, Miller RB, Porter VA, Milla CE, Cornfield DN (1996) NO causes perinatal pulmonary vasodilation though K+ channel activation and intracellular Ca2+ release. Am J Physiol 276:925–932
84.
Zurück zum Zitat Sbragia L, Paek B, Filly R (2000) Congenital diaphragmatic hernia without herniation of the liver: Does the lung-to-head ratio predict survival? J Ultrasound Med 19:845–848PubMed Sbragia L, Paek B, Filly R (2000) Congenital diaphragmatic hernia without herniation of the liver: Does the lung-to-head ratio predict survival? J Ultrasound Med 19:845–848PubMed
85.
Zurück zum Zitat Schachtner SK, Wang Y, Scott Baldwin H (2000) Qualitative and quantitative analysis of embryonic pulmonary vessel formation. Am J Respir Cell Mol Biol 22:157–165PubMed Schachtner SK, Wang Y, Scott Baldwin H (2000) Qualitative and quantitative analysis of embryonic pulmonary vessel formation. Am J Respir Cell Mol Biol 22:157–165PubMed
86.
Zurück zum Zitat Noori S, Friedlich P, Wong P, Garingo A, Seri I (2007) Cardiovascular effects of sildenafil in neonates and infants with congenital diaphragmatic hernia and pulmonary hypertension. Neonatology 91:92–100. doi:10.1159/000097125 PubMedCrossRef Noori S, Friedlich P, Wong P, Garingo A, Seri I (2007) Cardiovascular effects of sildenafil in neonates and infants with congenital diaphragmatic hernia and pulmonary hypertension. Neonatology 91:92–100. doi:10.​1159/​000097125 PubMedCrossRef
87.
Zurück zum Zitat Shaffer TH, Wolfson MR (1996) Liquid ventilation: an alternative ventilation strategy for management of neonatal respiratory distress. Eur J Pediatr 155(Suppl 2):S30–S34. doi:10.1007/BF01958078 PubMedCrossRef Shaffer TH, Wolfson MR (1996) Liquid ventilation: an alternative ventilation strategy for management of neonatal respiratory distress. Eur J Pediatr 155(Suppl 2):S30–S34. doi:10.​1007/​BF01958078 PubMedCrossRef
88.
Zurück zum Zitat Shehata SM, Sharma HS, Mooi WJ, Tibboel D (2006) Pulmonary hypertension in human newborns with congenital diaphragmatic hernia is associated with decreased vascular expression of nitric-oxide synthase. Cell Biochem Biophys 44:147–155. doi:10.1385/CBB:44:1:147 PubMedCrossRef Shehata SM, Sharma HS, Mooi WJ, Tibboel D (2006) Pulmonary hypertension in human newborns with congenital diaphragmatic hernia is associated with decreased vascular expression of nitric-oxide synthase. Cell Biochem Biophys 44:147–155. doi:10.​1385/​CBB:​44:​1:​147 PubMedCrossRef
91.
92.
Zurück zum Zitat Stolar CJ, Crisafi MA, Driscoll YT (1995) Neurocognitive outcome for neonates treated with extracorporeal membrane oxygenation: are infants with congenital diaphragmatic hernia different? J Pediatr Surg 30:366–371. doi:10.1016/0022-3468(95)90591-X PubMedCrossRef Stolar CJ, Crisafi MA, Driscoll YT (1995) Neurocognitive outcome for neonates treated with extracorporeal membrane oxygenation: are infants with congenital diaphragmatic hernia different? J Pediatr Surg 30:366–371. doi:10.​1016/​0022-3468(95)90591-X PubMedCrossRef
93.
Zurück zum Zitat Stolar CJH, Dillon PW (2006) Congenital diaphragmatic hernia and eventration. In: Grosfeld JL, O’Neill Jr JA, Fonkalsrud EW, Coran AG (eds) Pediatric surgery. 6th edn. Elsevier, Philadelphia, pp 931–954 Stolar CJH, Dillon PW (2006) Congenital diaphragmatic hernia and eventration. In: Grosfeld JL, O’Neill Jr JA, Fonkalsrud EW, Coran AG (eds) Pediatric surgery. 6th edn. Elsevier, Philadelphia, pp 931–954
96.
Zurück zum Zitat Sweed Y, Puri P (1993) Congenital diaphragmatic hernia: influence of associated malformations on survival. Arch Dis Child 69:68–70PubMedCrossRef Sweed Y, Puri P (1993) Congenital diaphragmatic hernia: influence of associated malformations on survival. Arch Dis Child 69:68–70PubMedCrossRef
97.
Zurück zum Zitat Swietlinski J, Swist-Szulik K, Maruniak-Cheduck I, Pyrkosz A (2002) Spondylothoracic dysostosis associated with diaphragmatic hernia and camptodactyly. Genet Couns 13:309–317PubMed Swietlinski J, Swist-Szulik K, Maruniak-Cheduck I, Pyrkosz A (2002) Spondylothoracic dysostosis associated with diaphragmatic hernia and camptodactyly. Genet Couns 13:309–317PubMed
99.
100.
Zurück zum Zitat Thébaud B, Mercier JC, Dinh-Xuan AT (1998) Congenital diaphragmatic hernia: a cause of persistent pulmonary hypertension of the newborn which lacks an effective therapy. Biol Neonate 74:323–336. doi:10.1159/000014050 PubMedCrossRef Thébaud B, Mercier JC, Dinh-Xuan AT (1998) Congenital diaphragmatic hernia: a cause of persistent pulmonary hypertension of the newborn which lacks an effective therapy. Biol Neonate 74:323–336. doi:10.​1159/​000014050 PubMedCrossRef
101.
Zurück zum Zitat Thébaud B, Tibboel D, Rambaud C (1999) Vitamin A decreases the incidence and severity of nitrophen-induced congenital diaphragmatic hernia in rats. Am J Physiol 277:L423–L429PubMed Thébaud B, Tibboel D, Rambaud C (1999) Vitamin A decreases the incidence and severity of nitrophen-induced congenital diaphragmatic hernia in rats. Am J Physiol 277:L423–L429PubMed
102.
Zurück zum Zitat Thebaud B, de Lagausie P, Forgues D, Aigrain Y, Mercier JC, Dinh-Xuan AT (2000) ET (A)-receptor blockade and ET (B)-receptor stimulation in experimental congenital diaphragmatic hernia. Am J Physiol Lung Cell Mol Physiol 278(5):L923–L932PubMed Thebaud B, de Lagausie P, Forgues D, Aigrain Y, Mercier JC, Dinh-Xuan AT (2000) ET (A)-receptor blockade and ET (B)-receptor stimulation in experimental congenital diaphragmatic hernia. Am J Physiol Lung Cell Mol Physiol 278(5):L923–L932PubMed
103.
Zurück zum Zitat Thébaud B, Barlier-Mur AM, Chailley-Heu B (2001) Restoring effects of vitamin A on surfactant synthesis in nitrofen-induced congenital diaphragmatic hernia in rats. Am J Respir Crit Care Med 164:1083–1089PubMed Thébaud B, Barlier-Mur AM, Chailley-Heu B (2001) Restoring effects of vitamin A on surfactant synthesis in nitrofen-induced congenital diaphragmatic hernia in rats. Am J Respir Crit Care Med 164:1083–1089PubMed
105.
111.
Zurück zum Zitat Wallace MJ, Thiel AM, Lines AM, Polglase GR, Sozo F, Hooper SB (2006) Role of platelet-derived growth factor-B, endothelial growth factor, insulin-like growth factor-II, mitogen-activated protein kinase and transforming growth factor-beta 1 in expansion-induced lung growth in fetal sheep. Reprod Fertil Dev 18:655–665. doi:10.1071/RD05163 PubMedCrossRef Wallace MJ, Thiel AM, Lines AM, Polglase GR, Sozo F, Hooper SB (2006) Role of platelet-derived growth factor-B, endothelial growth factor, insulin-like growth factor-II, mitogen-activated protein kinase and transforming growth factor-beta 1 in expansion-induced lung growth in fetal sheep. Reprod Fertil Dev 18:655–665. doi:10.​1071/​RD05163 PubMedCrossRef
112.
Zurück zum Zitat Walton JP, Hendricks-Munoz K (1991) Profile and stability of sensorineural hearing loss in persistent pulmonary hypertension of the newborn. J Speech Hear Res 34:1362–1370PubMed Walton JP, Hendricks-Munoz K (1991) Profile and stability of sensorineural hearing loss in persistent pulmonary hypertension of the newborn. J Speech Hear Res 34:1362–1370PubMed
114.
Zurück zum Zitat Wilson JM, DiFiore JW, Peters CA (1993) Experimental fetal tracheal ligation prevents the pulmonary hypoplasia associated with fetal nephrectomy: possible application for congenital diaphragmatic hernia. J Pediatr Surg 28:1433–1439. doi:10.1016/0022-3468(93)90426-L PubMedCrossRef Wilson JM, DiFiore JW, Peters CA (1993) Experimental fetal tracheal ligation prevents the pulmonary hypoplasia associated with fetal nephrectomy: possible application for congenital diaphragmatic hernia. J Pediatr Surg 28:1433–1439. doi:10.​1016/​0022-3468(93)90426-L PubMedCrossRef
116.
118.
Zurück zum Zitat Ziegler JW, Ivy DD, Fox JJ, Kinsella JP, Clarke WR, Abman SH (1995) Dipyridamole, a cGMP phosphodiesterase inhibitor, causes pulmonary vasodilation in the ovine fetus. Am J Physiol Heart Circ Physiol 269:H473–H479 Ziegler JW, Ivy DD, Fox JJ, Kinsella JP, Clarke WR, Abman SH (1995) Dipyridamole, a cGMP phosphodiesterase inhibitor, causes pulmonary vasodilation in the ovine fetus. Am J Physiol Heart Circ Physiol 269:H473–H479
Metadaten
Titel
Congenital diaphragmatic hernia: current status and review of the literature
verfasst von
Anthony S. de Buys Roessingh
Anh Tuan Dinh-Xuan
Publikationsdatum
01.04.2009
Verlag
Springer-Verlag
Erschienen in
European Journal of Pediatrics / Ausgabe 4/2009
Print ISSN: 0340-6199
Elektronische ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-008-0904-x

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