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Erschienen in: European Journal of Pediatrics 3/2013

01.03.2013 | Original Article

Incomplete clinical manifestation as a risk factor for coronary artery abnormalities in Kawasaki disease: a meta-analysis

verfasst von: Kee-Soo Ha, GiYoung Jang, JungHwa Lee, KwangChul Lee, YoungSook Hong, ChangSung Son, JooWon Lee

Erschienen in: European Journal of Pediatrics | Ausgabe 3/2013

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Abstract

Incomplete Kawasaki disease (KD) comprises a large proportion of the total number of cases. Although it has the potential of delaying diagnosis, it is not conclusive whether an incomplete presentation is a risk factor for coronary artery abnormalities (CAAs). We performed a meta-analysis to establish the risk of CAA in 20 studies including 4,504 cases and 32,519 controls, and the risk of giant aneurysm in two studies including 5,390 cases and 37,648 controls. The pooled results indicated that incomplete KD was associated with an increased risk of CAA [odds ratio (OR) = 1.447, 95 % confidence interval (CI) = 1.158–1.808, p = 0.001]. Subgroup analyses demonstrated higher associations in patients younger than 12 months (OR = 2.023, 95 % CI = 1.252–3.271, p = 0.004), Asians and Indians (OR = 1.57, 95 % CI = 1.234–1.999, p < 0.001 and OR = 7.088, 95 % CI = 1.640–30.631, p = 0.009, respectively). Subgroup analysis according to the period of patient enrollment before and after 2004 showed increased association of incomplete KD with CAA only among studies with patients enrolled after 2004 (OR = 1.969, 95 % CI = 1.240–3.127, p = 0.004). In conclusion, incomplete KD seems to be associated with an increased risk of CAA, and this is more prominent in patients younger than 12 months, Asians and Indians.
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Metadaten
Titel
Incomplete clinical manifestation as a risk factor for coronary artery abnormalities in Kawasaki disease: a meta-analysis
verfasst von
Kee-Soo Ha
GiYoung Jang
JungHwa Lee
KwangChul Lee
YoungSook Hong
ChangSung Son
JooWon Lee
Publikationsdatum
01.03.2013
Verlag
Springer-Verlag
Erschienen in
European Journal of Pediatrics / Ausgabe 3/2013
Print ISSN: 0340-6199
Elektronische ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-012-1891-5

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