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21.01.2017 | Original Article

Occurrence of atypical HUS associated with influenza B

verfasst von: Karen van Hoeve, Corinne Vandermeulen, Marc Van Ranst, Elena Levtchenko, Lambert van den Heuvel, Djalila Mekahli

Erschienen in: European Journal of Pediatrics | Ausgabe 4/2017

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Abstract

Hemolytic uremic syndrome (HUS) is a disease characterized by thrombotic microangiopathy with a triad of non-immune hemolytic anemia, thrombocytopenia, and renal impairment. Approximately 10% of cases of HUS are classified as atypical (aHUS). While today many genetically forms of aHUS pathology are known, only about 50% of carriers precipitate the disease. The reason remains unclear, and triggering events like intercurrent infections have been postulated. In rare cases, influenza A is the known trigger of aHUS; however, no cases of influenza B have been reported.

Conclusion: We describe for the first time that influenza B strain as a trigger for aHUS in children with primary hereditary forms. We also showed in our three cases that immunization appears to be safe; however, this needs to be confirmed in a larger cohort.

What is Known:

• Known triggers of aHUS are infectious specimen.

• Influenza A-associated aHUS cases are rarely published.

What is New:

• aHUS can be triggered by influenza B virus infection.

• Influenza vaccination of patients with aHUS appears safe.

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Titel: Occurrence of atypical HUS associated with influenza B
verfasst von: Karen van Hoeve
Corinne Vandermeulen
Marc Van Ranst
Elena Levtchenko
Lambert van den Heuvel
Djalila Mekahli
Publikationsdatum: 21.01.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Pediatrics / Ausgabe 4/2017
Print ISSN: 0340-6199
Elektronische ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-017-2856-5

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Occurrence of atypical HUS associated with influenza B

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