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Erschienen in: Journal of Cancer Research and Clinical Oncology 10/2009

01.10.2009 | Original Paper

RETRACTED ARTICLE: Overexpression of Cks1 is associated with poor survival by inhibiting apoptosis in breast cancer

verfasst von: Xiao-Chun Wang, Li-Li Tian, Jing Tian, Hai-Liang Wu, Ai-min Meng

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 10/2009

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Abstract

Purpose

The present study was undertaken to examine the amplification and expression status of Cks1 in breast cancer and its significance.

Methods

The amplification and expression status of Cks1 gene was examined by FISH, real-time PCR and immunohistochemistry, respectively. RNA interference was used to detect the effects of Cks1 on migration, invasion, cell cycle progress and apoptosis of breast cancer cells.

Results

Cks1 gene amplification was highly correlated with protein overexpression. Overexpression of Cks1 was strongly associated with lymph node metastasis and poor prognosis (P = 0.000, 95% CI (0.00–0.02); P = 0.008, 95% CI (0.001–0.05), respectively). Knockdown of Cks1 expression by RNA interference inhibited the cell cycle progress, migration and invasion ability of breast cancer cells. Moreover, overexpression of Cks1 inhibited apoptosis of breast cancer cells through MEK-Erk pathway.

Conclusion

Cks1 may be considered as potential novel prognostic markers and targets for the future development of specific therapeutic interventions in breast cancer.
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Metadaten
Titel
RETRACTED ARTICLE: Overexpression of Cks1 is associated with poor survival by inhibiting apoptosis in breast cancer
verfasst von
Xiao-Chun Wang
Li-Li Tian
Jing Tian
Hai-Liang Wu
Ai-min Meng
Publikationsdatum
01.10.2009
Verlag
Springer-Verlag
Erschienen in
Journal of Cancer Research and Clinical Oncology / Ausgabe 10/2009
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-009-0582-8

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