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Journal of Cancer Research and Clinical Oncology

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01.03.2010 | Original Paper

Efficacy of targeted therapy in patients with renal cell carcinoma with pre-existing or new bone metastases

verfasst von: Jakub Żołnierek, Pawel Nurzyński, Przemysław Langiewicz, Sylwia Oborska, Anna Waśko-Grabowska, Ewa Kuszatal, Beata Obrocka, Cezary Szczylik

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 3/2010

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Abstract

Introduction

This single-centre retrospective analysis of data from three randomised studies and two expanded-access studies compared the effect of interferon (IFN)-alfa, sunitinib, and sorafenib on the occurrence and progression of metastatic bone lesions in patients with renal cell carcinoma (RCC).

Methods

The analysis included 292 patients: 107 received sunitinib 50 mg/day in 6-week cycles (Schedule 4/2), 147 received sorafenib 800 mg/day, and 38 received placebo or IFN-alfa 9 MU t.i.w.

Results

Pre-existing metastatic bone lesions were reported in 82 patients, of which 30 experienced progression. Twenty-three of 210 patients developed new bone lesions. Overall, sunitinib appeared slightly more effective than sorafenib or IFN-alfa at extending mean time to progression of pre-existing bone lesions (P = 0.057). Compared with sorafenib, sunitinib significantly decreased formation (P = 0.034) and prolonged time to occurrence of new bone lesions (P = 0.047).

Conclusion

Further evaluation of the effect of these therapies on bone metastases in RCC is warranted.

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Titel: Efficacy of targeted therapy in patients with renal cell carcinoma with pre-existing or new bone metastases
verfasst von: Jakub Żołnierek
Pawel Nurzyński
Przemysław Langiewicz
Sylwia Oborska
Anna Waśko-Grabowska
Ewa Kuszatal
Beata Obrocka
Cezary Szczylik
Publikationsdatum: 01.03.2010
Verlag: Springer-Verlag
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 3/2010
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-009-0664-7

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