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Journal of Cancer Research and Clinical Oncology

Erschienen in:

01.12.2010 | Original Paper

Long-term interferon-α treatment suppresses tumor growth but promotes metastasis capacity in hepatocellular carcinoma

verfasst von: Peng-Yuan Zhuang, Ju-Bo Zhang, Wei Zhang, Xiao-Dong Zhu, Ying Liang, Hua-Xiang Xu, Yu-Quan Xiong, Ling-Qun Kong, Lu Wang, Wei-Zhong Wu, Zhao-You Tang, Lun-Xiu Qin, Hui-Chuan Sun

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 12/2010

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Abstract

Purpose

To elucidate the effect of IFN-α treatment on tumor growth and metastasis of hepatocellular carcinoma (HCC).

Methods

IFN-α administration was conducted in nude mice using an orthotopic implantation model of human HCC, and the key molecular markers in the IFN-α treatment was detected by immunohistochemistry staining and PCR array.

Results

Up to 12 weeks of IFN-α treatment significantly suppressed tumor growth of HCC, but relatively increased the number of circulating tumor cells, which might be due to the enhanced tumor hypoxia as well as up-regulation of metastasis-related genes, such as HIF-1α, c-met, u-PA, PDGF-A, and IL-8. However, IFN-α had no direct effect on migration and invasion of HCC cells.

Conclusions

IFN-α has janus face of consistently suppressing HCC growth, however, promoting tumor metastasis capacity, which is of clinical indication for the scientific administration of IFN-α and the similar antiangiogenesis drugs for their dual effect on tumor growth and metastasis.

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Titel: Long-term interferon-α treatment suppresses tumor growth but promotes metastasis capacity in hepatocellular carcinoma
verfasst von: Peng-Yuan Zhuang
Ju-Bo Zhang
Wei Zhang
Xiao-Dong Zhu
Ying Liang
Hua-Xiang Xu
Yu-Quan Xiong
Ling-Qun Kong
Lu Wang
Wei-Zhong Wu
Zhao-You Tang
Lun-Xiu Qin
Hui-Chuan Sun
Publikationsdatum: 01.12.2010
Verlag: Springer-Verlag
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 12/2010
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-010-0848-1

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Long-term interferon-α treatment suppresses tumor growth but promotes metastasis capacity in hepatocellular carcinoma

Abstract

Purpose

Methods

Results

Conclusions

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Update Onkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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