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Erschienen in: Journal of Cancer Research and Clinical Oncology 1/2011

01.01.2011 | Original Paper

The role of tumor invasion into the mandible of oral squamous cell carcinoma

verfasst von: Thomas Mücke, Frank Hölzle, Stefan Wagenpfeil, Klaus-Dietrich Wolff, Marco Kesting

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 1/2011

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Abstract

Purpose

The aim of this study was to determine the prognostic impact of the extent of bone invasion in patients undergoing mandibulectomy for oral squamous cell carcinoma (OSCC), and to evaluate the relation between clinicopathologic parameters and outcome.

Methods

Nine hundred and eighty-two patients presented with OSCC and 334 were treated surgically by some form of mandibular excision. Treatment included marginal, rim, or segmental mandibulectomy depending on the clinical and radiological observation of the mandible and suspected bone invasion. Kaplan–Meier plots and univariate log-rank test and multivariate Cox proportional hazards regression models were used to determine the association between possible predictor variables and survival time.

Results

After controlling for age, tumor and nodal stage, UICC stage, type of reconstruction, which were independent predictors of survival, type of mandibulectomy was significantly associated with survival in the univariate analysis (P = 0.038), whereas bone invasion was not in both univariate and multivariate analysis. The rate of bone invasion detected after marginal mandibulectomy was 15.5%, in rim resections 50%, and segmental mandibulectomy at 84.7%. Recurrence of OSCC was found to be associated with overall survival (P = 0.039).

Conclusions

If bone invasion is identified histologically in a resected specimen, the prognosis is not worsened and additional surgery need not be undertaken in adequately resected margins. Although the mandible should be preserved if feasible, the choice of treatment should always provide safe resection margin. The high rates of unsuspected bone invasion found in this study should be kept in mind in patients with OSCC close to the mandible.
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Metadaten
Titel
The role of tumor invasion into the mandible of oral squamous cell carcinoma
verfasst von
Thomas Mücke
Frank Hölzle
Stefan Wagenpfeil
Klaus-Dietrich Wolff
Marco Kesting
Publikationsdatum
01.01.2011
Verlag
Springer-Verlag
Erschienen in
Journal of Cancer Research and Clinical Oncology / Ausgabe 1/2011
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-010-0870-3

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