Skip to main content
Erschienen in: Journal of Cancer Research and Clinical Oncology 8/2015

01.08.2015 | Original Article – Cancer Research

Circulating MACC1 as a novel diagnostic and prognostic biomarker for nonsmall cell lung cancer

verfasst von: Zhiqiang Wang, Ming Cai, Yuan Weng, Fang Zhang, Dong Meng, Jun Song, Huan Zhou, Zongtao Xie

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 8/2015

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Metastasis-associated in colon cancer-1 (MACC1) is a newly identified gene that plays an important role in cancer progression and metastasis. MACC1 has important functions in the differentiation, invasion, and metastasis of nonsmall cell lung cancer (NSCLC). However, the value of circulating MACC1 as a potential diagnostic and prognostic biomarker for NSCLC remains unknown.

Methods

Plasma MACC1 mRNA levels were examined in 272 patients with NSCLC, 61 with benign lung disease, and 80 healthy volunteers using reverse transcription quantitative real-time polymerase chain reaction.

Results

MACC1 was more highly expressed in NSCLC patients than in patients with benign disease (P < 0.001) or in healthy volunteers (P < 0.001). High MACC1 expression was significantly associated with NSCLC stage (P = 0.013) and lymph node metastasis (P = 0.016). The area under the receiver operating characteristic curve was 0.766, and the optimal cutoff value was 0.105, providing a sensitivity of 71.4 % and a specificity of 89.1 %. The diagnostic capability of circulating MACC1 mRNA was higher than that of carcinoembryonic antigen (P = 0.025) or cytokeratin-19 (P = 0.010). Furthermore, high MACC1 expression was associated with poor overall survival (OS) and disease-free survival (DFS) and predicted poor survival in NSCLC patients. Consequently, MACC1 mRNA was an independent prognostic factor of OS and DFS.

Conclusion

We concluded that circulating MACC1 mRNA represents a potential noninvasive, diagnostic and prognostic marker for NSCLC.
Literatur
Zurück zum Zitat Cabrera-Alarcon JL, Carrillo-Vico A, Santotoribio JD, Leon-Justel A, Sanchez-Gil R, Gonzalez-Castro A, Guerrero JM (2011) CYFRA 21-1 as a tool for distant metastasis detection in lung cancer. Clin Lab 57:1011–1014PubMed Cabrera-Alarcon JL, Carrillo-Vico A, Santotoribio JD, Leon-Justel A, Sanchez-Gil R, Gonzalez-Castro A, Guerrero JM (2011) CYFRA 21-1 as a tool for distant metastasis detection in lung cancer. Clin Lab 57:1011–1014PubMed
Zurück zum Zitat Chundong G et al (2011) Molecular diagnosis of MACC1 status in lung adenocarcinoma by immunohistochemical analysis. Anticancer Res 31:1141–1145PubMed Chundong G et al (2011) Molecular diagnosis of MACC1 status in lung adenocarcinoma by immunohistochemical analysis. Anticancer Res 31:1141–1145PubMed
Zurück zum Zitat Fleischhacker M, Beinert T, Ermitsch M, Seferi D, Possinger K, Engelmann C, Jandrig B (2001) Detection of amplifiable messenger RNA in the serum of patients with lung cancer. Ann N Y Acad Sci 945:179–188PubMedCrossRef Fleischhacker M, Beinert T, Ermitsch M, Seferi D, Possinger K, Engelmann C, Jandrig B (2001) Detection of amplifiable messenger RNA in the serum of patients with lung cancer. Ann N Y Acad Sci 945:179–188PubMedCrossRef
Zurück zum Zitat Hagemann C et al (2013) Impact of MACC1 on human malignant glioma progression and patients’ unfavorable prognosis. Neurooncol 15:1696–1709. doi:10.1093/neuonc/not136 Hagemann C et al (2013) Impact of MACC1 on human malignant glioma progression and patients’ unfavorable prognosis. Neurooncol 15:1696–1709. doi:10.​1093/​neuonc/​not136
Zurück zum Zitat Holdenrieder S, Nagel D, Stieber P (2010) Estimation of prognosis by circulating biomarkers in patients with non-small cell lung cancer. Cancer Biomark 6:179–190. doi:10.3233/CBM-2009-0128 PubMed Holdenrieder S, Nagel D, Stieber P (2010) Estimation of prognosis by circulating biomarkers in patients with non-small cell lung cancer. Cancer Biomark 6:179–190. doi:10.​3233/​CBM-2009-0128 PubMed
Zurück zum Zitat Kawamura M et al (2012) Correlation of MACC1 and MET expression in rectal cancer after neoadjuvant chemoradiotherapy. Anticancer Res 32:1527–1531PubMed Kawamura M et al (2012) Correlation of MACC1 and MET expression in rectal cancer after neoadjuvant chemoradiotherapy. Anticancer Res 32:1527–1531PubMed
Zurück zum Zitat Kokoszynska K, Krynski J, Rychlewski L, Wyrwicz LS (2009) Unexpected domain composition of MACC1 links MET signaling and apoptosis. Acta Biochim Pol 56:317–323PubMed Kokoszynska K, Krynski J, Rychlewski L, Wyrwicz LS (2009) Unexpected domain composition of MACC1 links MET signaling and apoptosis. Acta Biochim Pol 56:317–323PubMed
Zurück zum Zitat Kopreski MS, Benko FA, Kwak LW, Gocke CD (1999) Detection of tumor messenger RNA in the serum of patients with malignant melanoma. Clin Cancer Res 5:1961–1965PubMed Kopreski MS, Benko FA, Kwak LW, Gocke CD (1999) Detection of tumor messenger RNA in the serum of patients with malignant melanoma. Clin Cancer Res 5:1961–1965PubMed
Zurück zum Zitat Lo KW et al (1999) Analysis of cell-free Epstein-barr virus associated RNA in the plasma of patients with nasopharyngeal carcinoma. Clin Chem 45:1292–1294PubMed Lo KW et al (1999) Analysis of cell-free Epstein-barr virus associated RNA in the plasma of patients with nasopharyngeal carcinoma. Clin Chem 45:1292–1294PubMed
Zurück zum Zitat Siegel R, Ward E, Brawley O, Jemal A (2011) Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 61:212–236. doi:10.3322/caac.20121 PubMedCrossRef Siegel R, Ward E, Brawley O, Jemal A (2011) Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 61:212–236. doi:10.​3322/​caac.​20121 PubMedCrossRef
Zurück zum Zitat Wang L et al (2013) Metastasis-associated in colon cancer-1 upregulation predicts a poor prognosis of gastric cancer, and promotes tumor cell proliferation and invasion. Int J Cancer 133:1419–1430. doi:10.1002/ijc.28140 PubMedCrossRef Wang L et al (2013) Metastasis-associated in colon cancer-1 upregulation predicts a poor prognosis of gastric cancer, and promotes tumor cell proliferation and invasion. Int J Cancer 133:1419–1430. doi:10.​1002/​ijc.​28140 PubMedCrossRef
Zurück zum Zitat Zhang RT, Shi HR, Huang HL, Chen ZM, Liu HN, Yuan ZF (2011) Expressions of MACC1, HGF, and C-met protein in epithelial ovarian cancer and their significance. J South Med Univ 31:1551–1555 Zhang RT, Shi HR, Huang HL, Chen ZM, Liu HN, Yuan ZF (2011) Expressions of MACC1, HGF, and C-met protein in epithelial ovarian cancer and their significance. J South Med Univ 31:1551–1555
Zurück zum Zitat Zhang X et al (2012) Detection of circulating Bmi-1 mRNA in plasma and its potential diagnostic and prognostic value for uterine cervical cancer. Int J Cancer 131:165–172. doi:10.1002/ijc.26360 PubMedCrossRef Zhang X et al (2012) Detection of circulating Bmi-1 mRNA in plasma and its potential diagnostic and prognostic value for uterine cervical cancer. Int J Cancer 131:165–172. doi:10.​1002/​ijc.​26360 PubMedCrossRef
Zurück zum Zitat Zhang K et al (2013a) MACC1 is involved in the regulation of proliferation, colony formation, invasion ability, cell cycle distribution, apoptosis and tumorigenicity by altering Akt signaling pathway in human osteosarcoma. Tumour Biol. doi:10.1007/s13277-013-1335-5 Zhang K et al (2013a) MACC1 is involved in the regulation of proliferation, colony formation, invasion ability, cell cycle distribution, apoptosis and tumorigenicity by altering Akt signaling pathway in human osteosarcoma. Tumour Biol. doi:10.​1007/​s13277-013-1335-5
Zurück zum Zitat Zhang K, Zhang Y, Zhu H, Xue N, Liu J, Shan C, Zhu Q (2013b) High expression of MACC1 predicts poor prognosis in patients with osteosarcoma. Tumour Biol. doi:10.1007/s13277-013-1180-6 Zhang K, Zhang Y, Zhu H, Xue N, Liu J, Shan C, Zhu Q (2013b) High expression of MACC1 predicts poor prognosis in patients with osteosarcoma. Tumour Biol. doi:10.​1007/​s13277-013-1180-6
Zurück zum Zitat Zhu M, Xu Y, Mao X, Gao Y, Shao L, Yan F (2013) Overexpression of metastasis-associated in colon cancer-1 associated with poor prognosis in patients with esophageal cancer. Pathol Oncol Res 19:749–753. doi:10.1007/s12253-013-9638-9 PubMedCrossRef Zhu M, Xu Y, Mao X, Gao Y, Shao L, Yan F (2013) Overexpression of metastasis-associated in colon cancer-1 associated with poor prognosis in patients with esophageal cancer. Pathol Oncol Res 19:749–753. doi:10.​1007/​s12253-013-9638-9 PubMedCrossRef
Metadaten
Titel
Circulating MACC1 as a novel diagnostic and prognostic biomarker for nonsmall cell lung cancer
verfasst von
Zhiqiang Wang
Ming Cai
Yuan Weng
Fang Zhang
Dong Meng
Jun Song
Huan Zhou
Zongtao Xie
Publikationsdatum
01.08.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Cancer Research and Clinical Oncology / Ausgabe 8/2015
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-014-1903-0

Weitere Artikel der Ausgabe 8/2015

Journal of Cancer Research and Clinical Oncology 8/2015 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.