nach oben

Journal of Cancer Research and Clinical Oncology

Erschienen in:

16.09.2016 | Review – Cancer Research

CCAT1: an oncogenic long noncoding RNA in human cancers

verfasst von: Xiaoqiang Guo, Yuming Hua

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 4/2017

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Long noncoding RNAs (lncRNAs) are a new class of noncoding RNAs that participate in a variety of biological processes such as cell proliferation, cell cycle, differentiation and apoptosis, mainly by regulation of gene expression at various levels, including chromatin, splicing, transcriptional and post-transcriptional levels. CCAT1 is a recently identified oncogenic lncRNA, which has been reported to be consistently upregulated in multiple cancer tissues and closely correlated with initiation and progression of cancers. The aim of this paper is to provide an overview of various roles of CCAT1 in human cancers.

Methods and results

We searched studies in electronic databases. Studies have shown the high expression pattern and oncogenic role of CCAT1 in different types of cancer, and aberrant expression of CCAT1 is involved in several processes correlated with carcinogenesis such as cell proliferation, apoptosis, migration and invasion by regulating different target genes and pathways.

Conclusion

LncRNA CCAT1 promises to be a novel diagnostic biomarker, therapeutic target, as well as prognostic biomarker in human cancers.

Alaiyan B et al (2013) Differential expression of colon cancer associated transcript1 (CCAT1) along the colonic adenoma-carcinoma sequence. BMC Cancer 13:196. doi:10.1186/1471-2407-13-196 CrossRefPubMedPubMedCentral

Blackwood EM, Eisenman RN (1991) Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science (New York, NY) 251:1211–1217CrossRef

Boyerinas B, Park SM, Hau A, Murmann AE, Peter ME (2010) The role of let-7 in cell differentiation and cancer. Endocr Relat Cancer 17:F19–F36. doi:10.1677/erc-09-0184 CrossRefPubMed

Cabanski CR, White NM, Dang HX, Silva-Fisher JM, Rauck CE, Cicka D, Maher CA (2015) Pan-cancer transcriptome analysis reveals long noncoding RNAs with conserved function. RNA Biol 12:628–642. doi:10.1080/15476286.2015.1038012 CrossRefPubMedPubMedCentral

Chen L, Wang W, Cao L, Li Z, Wang X (2016) Long non-coding RNA CCAT1 acts as a competing endogenous RNA to regulate cell growth and differentiation in acute myeloid leukemia. Mol Cells 39:330–330. doi:10.14348/molcells.2016.2308 CrossRefPubMedPubMedCentral

Cole MD, Henriksson M (2006) 25 Years of the c-Myc oncogene. Semin Cancer Biol 16:241. doi:10.1016/j.semcancer.2006.08.003 CrossRefPubMed

Dang CV, O’Donnell KA, Zeller KI, Nguyen T, Osthus RC, Li F (2006) The c-Myc target gene network. Semin Cancer Biol 16:253–264. doi:10.1016/j.semcancer.2006.07.014 CrossRefPubMed

de Hoon M, Shin JW, Carninci P (2015) Paradigm shifts in genomics through the FANTOM projects. Mamm Genome 26:391–402. doi:10.1007/s00335-015-9593-8 CrossRefPubMedPubMedCentral

Deng K, Guo X, Wang H, Xia J (2014) The lncRNA-MYC regulatory network in cancer. Tumour Biol 35:9497–9503. doi:10.1007/s13277-014-2511-y CrossRefPubMed

Deng L, Yang SB, Xu FF, Zhang JH (2015) Long noncoding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let-7 sponge. J Exp Clin Cancer Res 34:18. doi:10.1186/s13046-015-0136-7 CrossRefPubMedPubMedCentral

Denzler R, Agarwal V, Stefano J, Bartel DP, Stoffel M (2014) Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance. Mol Cell 54:766–776. doi:10.1016/j.molcel.2014.03.045 CrossRefPubMedPubMedCentral

Feldstein O, Nizri T, Doniger T, Jacob J, Rechavi G, Ginsberg D (2013) The long non-coding RNA ERIC is regulated by E2F and modulates the cellular response to DNA damage. Mol Cancer 12:131. doi:10.1186/1476-4598-12-131 CrossRefPubMedPubMedCentral

He X et al (2014) C-Myc-activated long noncoding RNA CCAT1 promotes colon cancer cell proliferation and invasion. Tumour Biol 35:12181–12188. doi:10.1007/s13277-014-2526-4 CrossRefPubMed

Ji P et al (2003) MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene 22:8031–8041. doi:10.1038/sj.onc.1206928 CrossRefPubMed

Kam Y et al (2014) Detection of a long non-coding RNA (CCAT1) in living cells and human adenocarcinoma of colon tissues using FIT-PNA molecular beacons. Cancer Lett 352:90–96. doi:10.1016/j.canlet.2013.02.014 CrossRefPubMed

Kapranov P et al (2007) RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science (New York, NY) 316:1484–1488. doi:10.1126/science.1138341 CrossRef

Kapranov P et al (2010) The majority of total nuclear-encoded non-ribosomal RNA in a human cell is ‘dark matter’ un-annotated RNA. BMC Biol 8:149. doi:10.1186/1741-7007-8-149 CrossRefPubMedPubMedCentral

Kim K et al (2013) HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene 32:1616–1625. doi:10.1038/onc.2012.193 CrossRefPubMed

Kim T et al (2014) Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5. Proc Natl Acad Sci USA 111:4173–4178. doi:10.1073/pnas.1400350111 CrossRefPubMedPubMedCentral

Lazorthes S et al (2015) A vlincRNA participates in senescence maintenance by relieving H2AZ-mediated repression at the INK4 locus. Nat Commun 6:5971. doi:10.1038/ncomms6971 CrossRefPubMedPubMedCentral

Li F, Liang X, Chen Y, Li S, Liu J (2014) Role of microRNA-93 in regulation of angiogenesis. Tumour Biol 35:10609–10613. doi:10.1007/s13277-014-2605-6 CrossRefPubMed

Liu SP, Yang JX, Cao DY, Shen K (2013) Identification of differentially expressed long non-coding RNAs in human ovarian cancer cells with different metastatic potentials. Cancer Biol Med 10:138–141. doi:10.7497/j.issn.2095-3941.2013.03.003 PubMedPubMedCentral

Liu XH et al (2014) Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer. Mol Cancer 13:92. doi:10.1186/1476-4598-13-92 CrossRefPubMedPubMedCentral

Luo J et al (2014) Long non-coding RNA CARLo-5 is a negative prognostic factor and exhibits tumor pro-oncogenic activity in non-small cell lung cancer. Tumour Biol 35:11541–11549. doi:10.1007/s13277-014-2442-7 CrossRefPubMed

Ma C, Shi X, Zhu Q, Li Q, Liu Y, Yao Y, Song Y (2015a) The growth arrest-specific transcript 5 (GAS5): a pivotal tumor suppressor long noncoding RNA in human cancers. Tumour Biol 37:1437–1444. doi:10.1007/s13277-015-4521-9 CrossRefPubMed

Ma MZ, Chu BF, Zhang Y, Weng MZ, Qin YY, Gong W, Quan ZW (2015b) Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5p. Cell Death Dis 6:e1583. doi:10.1038/cddis.2014.541 CrossRefPubMedPubMedCentral

Mattick JS, Makunin IV (2006) Non-coding RNA. Human Mol Genet 15(1):R17–R29. doi:10.1093/hmg/ddl046

McCleland ML et al (2016) CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Investig 126:639–652. doi:10.1172/jci83265 CrossRefPubMedPubMedCentral

Mizrahi I et al (2015) Colon Cancer Associated Transcript-1 (CCAT1) expression in adenocarcinoma of the stomach. J Cancer 6:105–110. doi:10.7150/jca.10568 CrossRefPubMedPubMedCentral

Nesbit CE, Tersak JM, Prochownik EV (1999) MYC oncogenes and human neoplastic disease. Oncogene 18:3004–3016. doi:10.1038/sj.onc.1202746 CrossRefPubMed

Nissan A et al (2012) Colon cancer associated transcript-1: a novel RNA expressed in malignant and pre-malignant human tissues. Int J Cancer 130:1598–1606. doi:10.1002/ijc.26170 CrossRefPubMed

Pennisi E (2012) Genomics. ENCODE project writes eulogy for junk DNA. Science (New York, NY) 337(1159):1161. doi:10.1126/science.337.6099.1159

Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, Pandolfi PP (2010) A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature 465:1033–1038. doi:10.1038/nature09144 CrossRefPubMedPubMedCentral

Sharma S, Kelly TK, Jones PA (2010) Epigenetics in cancer. Carcinogenesis 31:27–36. doi:10.1093/carcin/bgp220 CrossRefPubMed

Shi J, Vakoc CR (2014) The mechanisms behind the therapeutic activity of BET bromodomain inhibition. Mol Cell 54:728–736. doi:10.1016/j.molcel.2014.05.016 CrossRefPubMed

Siegel RL, Miller KD, Jemal A (2016) Cancer statistics, 2016. CA Cancer J Clin 66:7–30. doi:10.3322/caac.21332 CrossRefPubMed

St Laurent G et al (2013) VlincRNAs controlled by retroviral elements are a hallmark of pluripotency and cancer. Genome Biol 14:R73. doi:10.1186/gb-2013-14-7-r73 CrossRefPubMedPubMedCentral

St Laurent G, Wahlestedt C, Kapranov P (2015) The Landscape of long noncoding RNA classification. Trends Genet 31:239–251. doi:10.1016/j.tig.2015.03.007 CrossRefPubMedPubMedCentral

Su Z, Yang Z, Xu Y, Chen Y, Yu Q (2015) MicroRNAs in apoptosis, autophagy and necroptosis. Oncotarget 6:8474–8490. doi:10.18632/oncotarget.3523 CrossRefPubMedPubMedCentral

Sun M et al (2014) EZH2-mediated epigenetic suppression of long noncoding RNA SPRY4-IT1 promotes NSCLC cell proliferation and metastasis by affecting the epithelial-mesenchymal transition. Cell Death Dis 5:e1298. doi:10.1038/cddis.2014.256 CrossRefPubMedPubMedCentral

Taby R, Issa JP (2010) Cancer epigenetics. CA Cancer J Clin 60:376–392. doi:10.3322/caac.20085 CrossRefPubMed

Tang R et al (2016) MiR-let-7a inhibits cell proliferation, migration, and invasion by down-regulating PKM2 in gastric cancer. Oncotarget 7:5972–5984. doi:10.18632/oncotarget.6821 PubMedPubMedCentral

Thomson DW, Dinger ME (2016) Endogenous microRNA sponges: evidence and controversy. Nat Rev Genet 17:272–283. doi:10.1038/nrg.2016.20 CrossRefPubMed

Tong YS et al (2015) Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma. Mol Cancer 14:3. doi:10.1186/1476-4598-14-3 CrossRefPubMedPubMedCentral

Wang F et al (2014) Development and prospective multicenter evaluation of the long noncoding RNA MALAT-1 as a diagnostic urinary biomarker for prostate cancer. Oncotarget 5:11091–11102. doi:10.18632/oncotarget.2691 CrossRefPubMedPubMedCentral

Wang F, Xie C, Zhao W, Deng Z, Yang H, Fang Q (2015) Long non-coding RNA CARLo-5 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients. Clin Exp Med 1–11. doi:10.1007/s10238-015-0395-9

Xiang JF et al (2014) Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus. Cell Res 24:513–531. doi:10.1038/cr.2014.35 CrossRefPubMedPubMedCentral

Yang F, Xue X, Bi J, Zheng L, Zhi K, Gu Y, Fang G (2013) Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma. J Cancer Res Clin Oncol 139:437–445. doi:10.1007/s00432-012-1324-x CrossRefPubMed

Ye Z, Zhou M, Tian B, Wu B, Li J (2015) Expression of lncRNA-CCAT1, E-cadherin and N-cadherin in colorectal cancer and its clinical significance. Int J Clin Exp Med 8:3707–3715PubMedPubMedCentral

Yoshino H, Seki N, Itesako T, Chiyomaru T, Nakagawa M, Enokida H (2013) Aberrant expression of microRNAs in bladder cancer. Nat Rev Urol 10:396–404. doi:10.1038/nrurol.2013.113 CrossRefPubMed

Zhang X et al (2010) Maternally expressed gene 3, an imprinted noncoding RNA gene, is associated with meningioma pathogenesis and progression. Cancer Res 70:2350–2358. doi:10.1158/0008-5472.can-09-3885 CrossRefPubMedPubMedCentral

Zhang Z et al (2013) Negative regulation of lncRNA GAS5 by miR-21. Cell Death Differ 20:1558–1568. doi:10.1038/cdd.2013.110 CrossRefPubMedPubMedCentral

Zhang EB et al (2014a) P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression. Cell Death Dis 5:e1243. doi:10.1038/cddis.2014.201 CrossRefPubMedPubMedCentral

Zhang Y, Ma M, Liu W, Ding W, Yu H (2014b) Enhanced expression of long noncoding RNA CARLo-5 is associated with the development of gastric cancer. Int J Clin Exp Pathol 7:8471–8479PubMedPubMedCentral

Zhang XF, Liu T, Li Y, Li S (2015) Overexpression of long non-coding RNA CCAT1 is a novel biomarker of poor prognosis in patients with breast cancer. Int J Clin Exp Pathol 8:9440–9445PubMedPubMedCentral

Zhao W, Song M, Zhang J, Kuerban M, Wang H (2015) Combined identification of long non-coding RNA CCAT1 and HOTAIR in serum as an effective screening for colorectal carcinoma. Int J Clin Exp Pathol 8:14131–14140PubMedPubMedCentral

Zhou Y, Zhang X, Klibanski A (2012) MEG3 noncoding RNA: a tumor suppressor. J Mol Endocrinol 48:R45–R53. doi:10.1530/jme-12-0008 CrossRefPubMedPubMedCentral

Zhou X, Yin C, Dang Y, Ye F, Zhang G (2015) Identification of the long non-coding RNA H19 in plasma as a novel biomarker for diagnosis of gastric cancer. Sci Rep 5:11516. doi:10.1038/srep11516 CrossRefPubMedPubMedCentral

Zhou B et al (2016) The long noncoding RNA colon cancer-associated transcript-1/miR-490 axis regulates gastric cancer cell migration by targeting hnRNPA1. IUBMB Life. doi:10.1002/iub.1474

Zhu H, Zhou X, Chang H, Li H, Liu F, Ma C, Lu J (2015a) CCAT1 promotes hepatocellular carcinoma cell proliferation and invasion. Int J Clin Exp Pathol 8:5427–5434PubMedPubMedCentral

Zhu HQ, Zhou X, Chang H, Li HG, Liu FF, Ma CQ, Lu J (2015b) Aberrant expression of CCAT1 regulated by c-Myc predicts the prognosis of hepatocellular carcinoma. Asian Pac J Cancer Prevent 16:5181–5185CrossRef

Titel: CCAT1: an oncogenic long noncoding RNA in human cancers
verfasst von: Xiaoqiang Guo
Yuming Hua
Publikationsdatum: 16.09.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 4/2017
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-016-2268-3

Neu im Fachgebiet Onkologie

23.04.2024 | Medikamente in Schwangerschaft und Stillzeit | Nachrichten

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

CCAT1: an oncogenic long noncoding RNA in human cancers

Abstract

Purpose

Methods and results

Conclusion

Neu im Fachgebiet Onkologie

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Stufenschema weist Prostatakarzinom zuverlässig nach

Update Onkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods and results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2017

Distribution of TERT promoter mutations in primary and metastatic melanomas in Austrian patients

Depletion of p42.3 gene inhibits proliferation and invasion in melanoma cells

Comprehensive gene and microRNA expression profiling reveals a role for miRNAs in the oncogenic roles of SphK1 in papillary thyroid cancer

Influence of the HER receptor ligand system on sensitivity to cetuximab and trastuzumab in gastric cancer cell lines

Low-dose anti-thymocyte globulin reduce severe acute and chronic graft-versus-host disease after allogeneic stem cell transplantation

Current developments in cancer care: including the patients’ perspective—3rd European Roundtable Meeting (ERTM) June 17, 2016, Berlin, Germany

Neu im Fachgebiet Onkologie

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Stufenschema weist Prostatakarzinom zuverlässig nach

Update Onkologie