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The impact of IgG antibodies to recombinant Plasmodium falciparum 732var CIDR-1α domain in mothers and their newborn babies

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Abstract

Different domains of a novel full-length var gene (termed 732var) isolated from a placenta of a malaria-infected woman were expressed in Escherichia coli as recombinant proteins and analysed biochemically and immunologically. Two of these, the Duffy binding-like (DBL)-3γ domain and the cysteine-rich interdomain region (CIDR)-1α were able to bind chondroitin sulfate A and CD36, respectively. The DBL-3γ domain was investigated in a previous study and confirmed here to exhibit anti-disease characteristics related to pregnancy-associated malaria. Mothers with high anti-DBL-3γ antibody levels were protected from placental infection. The novel finding in this study is that babies born to mothers carrying anti-CIDR-1α antibodies had a delayed time to the first infection.

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Abbreviations

CSA:

chondroitin sulfate A

CIDR:

cysteine-rich interdomain region

DBL:

Duffy-binding-like

IE:

infected erythrocytes

PAM:

pregnancy-associated malaria

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Acknowledgements

We thank all the participants of this study. This work was supported by grants from the European Commission (QLK2-CT-2001-01302), Friends of the Bernhard-Nocht Institute for Tropical Medicine and the Chica and Heinz Schaller Foundation and the French Ministry of Research (ACI Pal+/2001).

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Authors and Affiliations

  1. Department for Molecular Medicine, Bernhard–Nocht Institute for Tropical Medicine, Hamburg, Germany

    Ayman Khattab, Yu-Shan Chia, Jürgen May & Mo-Quen Klinkert

  2. Institut de Recherche pour le Développement, UR010, Université René Descartes, IFR71, Paris, France

    Jean-Yves Le Hesran & Philippe Deloron

Authors
  1. Ayman Khattab
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  2. Yu-Shan Chia
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  3. Jürgen May
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  4. Jean-Yves Le Hesran
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  5. Philippe Deloron
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  6. Mo-Quen Klinkert
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Corresponding author

Correspondence to Ayman Khattab.

Additional information

Ayman Khattab and Yu-Shan Chia have contributed equally to the work.

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Khattab, A., Chia, YS., May, J. et al. The impact of IgG antibodies to recombinant Plasmodium falciparum 732var CIDR-1α domain in mothers and their newborn babies. Parasitol Res 101, 767–774 (2007). https://doi.org/10.1007/s00436-007-0548-1

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  • DOI: https://doi.org/10.1007/s00436-007-0548-1

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