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Screening of the C677T mutation on the methylenetetrahydrofolate reductase gene in French patients with neural tube defects

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Abstract

We report the analysis of the distribution of the C677T mutation on the methylenetetrahydrofolate reductase (MTHFR) gene in prenatally diagnosed neural tube defects (NTD) cases and controls. In contrast to previous reports, we found the same distribution in fetuses with NTD and controls, which suggests that the MTHFR C677T mutation cannot be regarded as a genetic risk factor for NTD.

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Authors and Affiliations

  1. Laboratoire de Cytogénétique et Génétique Moléculaire Humaine, Université de Versailles-Saint Quentin, 45 Avenue des Etats-Unis, F-78035 Versailles Cedex, France Tel.: (33) 01 39 25 46 76; Fax: (33) 01 39 25 46 78 e-mail: Etienne.Mornet@cytogene.uvsq.fr, , , , , , FR

    E. Mornet, Françoise Muller, Annie Lenvoisé-Furet & Jean-Louis Serre

  2. Centre d’Etudes de Biologie Prénatale – SESEP, Université de Versailles-Saint Quentin, Versailles, France, , , , , , FR

    Brigitte Simon-Bouy

  3. Unité de Foetopathologie, Hôpital Necker-Enfants Malades, Paris, France, , , , , , FR

    Anne-Lise Delezoide

  4. Gynécologie Obstétrique, Centre Hospitalier du Havre, Le Havre, France, , , , , , FR

    Jean-Yves Col

Authors
  1. E. Mornet
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  2. Françoise Muller
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  3. Annie Lenvoisé-Furet
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  4. Anne-Lise Delezoide
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  5. Jean-Yves Col
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  6. Brigitte Simon-Bouy
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  7. Jean-Louis Serre
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Additional information

Received: 23 April 1997 / Accepted: 28 May 1997

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Mornet, E., Muller, F., Lenvoisé-Furet, A. et al. Screening of the C677T mutation on the methylenetetrahydrofolate reductase gene in French patients with neural tube defects. Hum Genet 100, 512–514 (1997). https://doi.org/10.1007/s004390050544

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  • DOI: https://doi.org/10.1007/s004390050544

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