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A review of crosstalk between MAPK and Wnt signals and its impact on cartilage regeneration

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Abstract

Chondrogenesis is a developmental process that is controlled and coordinated by many growth and differentiation factors, in addition to environmental factors that initiate or suppress cellular signaling pathways and the transcription of specific genes in a temporal-spatial manner. As key signaling molecules in regulating cell proliferation, homeostasis and development, both mitogen-activated protein kinases (MAPK) and the Wnt family participate in morphogenesis and tissue patterning, playing important roles in skeletal development, especially chondrogenesis. Recent findings suggest that both signals are also actively involved in arthritis and related diseases. Despite the implication that crosstalk between MAPK and Wnt signaling has a significant function in cancer, few studies have summarized this interaction and its regulation of chondrogenesis. In this review, we focus on MAPK and Wnt signaling, referencing their relationships in various types of cells and particularly to their influence on chondrogenesis and cartilage development. We also discuss the interactions between MAPK and Wnt signaling with respect to cartilage-related diseases such as osteoarthritis and explore potential therapeutic targets for disease treatments.

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Acknowledgments

The authors thank Suzanne Danley for help in editing the manuscript.

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Authors and Affiliations

  1. Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, PO Box 9196, One Medical Center Drive, Morgantown, WV 26506-9196, USA

    Ying Zhang, Tyler Pizzute & Ming Pei

  2. Exercise Physiology, West Virginia University, Morgantown, WV 26506, USA

    Tyler Pizzute & Ming Pei

  3. Mechanical & Aerospace Engineering, West Virginia University, Morgantown, WV 26506, USA

    Ying Zhang & Ming Pei

Authors
  1. Ying Zhang
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  2. Tyler Pizzute
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  3. Ming Pei
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Corresponding author

Correspondence to Ming Pei.

Additional information

This project was partially supported by the AO Foundation (S-12-19P) and the National Institutes of Health (NIH) (1 R03 AR062763-01A1).

The authors declare no potential conflicts of interest.

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Zhang, Y., Pizzute, T. & Pei, M. A review of crosstalk between MAPK and Wnt signals and its impact on cartilage regeneration. Cell Tissue Res 358, 633–649 (2014). https://doi.org/10.1007/s00441-014-2010-x

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  • DOI: https://doi.org/10.1007/s00441-014-2010-x

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