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Differential distribution of probenecid as detected by on-tissue mass spectrometry

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Abstract

We demonstrate, by means of on-tissue mass spectrometry of tissue sections, that the drug probenecid can penetrate the blood–brain barrier. This method holds general promise for the detection and distribution of small molecule drugs within organ and tissue compartments.

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Acknowledgments

Ms Ann Soether is gratefully acknowledged for language correction.

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Correspondence to Thomas Tschernig.

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Yulin Qi and Nadine Hainz contributed equally to this work.

The authors acknowledge financial support from the DFG, which funded the FTICR-MS instrument. D.A.V. acknowledges general research support by the Alfried Krupp von Bohlen und Halbach Stiftung.

All authors declare that they have no competing interests.

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Qi, Y., Hainz, N., Tschernig, T. et al. Differential distribution of probenecid as detected by on-tissue mass spectrometry. Cell Tissue Res 360, 427–429 (2015). https://doi.org/10.1007/s00441-015-2153-4

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  • DOI: https://doi.org/10.1007/s00441-015-2153-4

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