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Erschienen in: Dysphagia 2/2015

01.04.2015 | Original Article

The Effect of Prophylactic Percutaneous Endoscopic Gastrostomy (PEG) Tube Placement on Swallowing and Swallow-Related Outcomes in Patients Undergoing Radiotherapy for Head and Neck Cancer: A Systematic Review

verfasst von: Stephanie M. Shaw, Heather Flowers, Brian O’Sullivan, Andrew Hope, Louis W. C. Liu, Rosemary Martino

Erschienen in: Dysphagia | Ausgabe 2/2015

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Abstract

Patients undergoing radiotherapy for head and neck cancer (HNC) often experience malnutrition and dehydration during treatment. As a result, some centres place PEG tubes prophylactically (pPEG) to prevent these negative consequences. However, recent research has suggested that pPEG use may negatively affect swallowing physiology, function and/or quality of life, especially in the long term. The purpose of this study was to systematically review the literature on pPEG use in HNC patients undergoing radiotherapy and to determine its impact on swallowing-related outcomes. The following electronic databases were searched for all relevant primary research published through February 24, 2014: AMED, CINAHL, the Cochrane Library, Embase, Healthstar, Medline, and PsycINFO. Main search terms included HNC, radiotherapy, deglutition disorders, feeding tube(s), and prophylactic or elective. References for all accepted papers were hand searched to identify additional relevant research. Methodological quality was assessed using Cochrane’s Risk of Bias. At all levels, two blinded raters provided judgments. Discrepancies were resolved by consensus. The search retrieved 181 unique citations. Twenty studies met our inclusion criteria. Quality assessment revealed that all studies were at risk for bias due to non-randomized sampling and unreported or inadequate blinding. Ten studies demonstrated selection bias with significant baseline differences between pPEG patients and controls. Results regarding the frequency and severity of dysphagia and swallowing-related outcomes were varied and inconclusive. The impact of pPEG use on swallowing and swallowing-related outcomes remains unclear. Well-controlled, randomized trials are needed to determine if pPEG places patients at greater risk for developing long-term dysphagia.
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Literatur
1.
Zurück zum Zitat Forte T, Niu J, Lockwood GA, Bryant HE. Incidence trends in head and neck cancers and human papillomavirus (HPV)-associated oropharyngeal cancer in Canada, 1992–2009. Cancer Causes Control. 2012;23(8):1343–8. doi:10.1007/s10552-012-0013-z.PubMedCrossRef Forte T, Niu J, Lockwood GA, Bryant HE. Incidence trends in head and neck cancers and human papillomavirus (HPV)-associated oropharyngeal cancer in Canada, 1992–2009. Cancer Causes Control. 2012;23(8):1343–8. doi:10.​1007/​s10552-012-0013-z.PubMedCrossRef
6.
Zurück zum Zitat Bachaud J-M, Cohen-Jonathan E, Alzieu C, David J-M, Serrano E, Daly-Schveitzer N. Combined postoperative radiotherapy and weekly cisplatin infusion for locally advanced head and neck carcinoma: final report of a randomized trial. Int J Radiat Oncol Biol Phys. 1996;36(5):999–1004. doi:10.1016/S0360-3016(96)00430-0.PubMedCrossRef Bachaud J-M, Cohen-Jonathan E, Alzieu C, David J-M, Serrano E, Daly-Schveitzer N. Combined postoperative radiotherapy and weekly cisplatin infusion for locally advanced head and neck carcinoma: final report of a randomized trial. Int J Radiat Oncol Biol Phys. 1996;36(5):999–1004. doi:10.​1016/​S0360-3016(96)00430-0.PubMedCrossRef
7.
Zurück zum Zitat Fu KK. Combined-modality therapy for head and neck cancer. Oncology. 1997;11(12):1781.PubMed Fu KK. Combined-modality therapy for head and neck cancer. Oncology. 1997;11(12):1781.PubMed
8.
Zurück zum Zitat Redda MGR, Ragona R, Ricardi U, Beltramo G, Rampino M, Gabriele P, Allis S, et al. Radiotherapy alone or with concomitant daily low-dose carboplatin in locally advanced, unresectable head and neck cancer: definitive results of a phase III study with a follow-up period of up to ten years. Tumori. 2010;96:246–53. doi:10.1700/488.5774. Redda MGR, Ragona R, Ricardi U, Beltramo G, Rampino M, Gabriele P, Allis S, et al. Radiotherapy alone or with concomitant daily low-dose carboplatin in locally advanced, unresectable head and neck cancer: definitive results of a phase III study with a follow-up period of up to ten years. Tumori. 2010;96:246–53. doi:10.​1700/​488.​5774.
9.
Zurück zum Zitat Zackrisson B, Mercke C, Strander H, Wennerberg J, Cavallin-Ståhl E. A systematic overview of radiation therapy effects in head and neck cancer. Acta Otolaryngol. 2003;42(5–6):443–61. doi:10.1080/02841860310014886. Zackrisson B, Mercke C, Strander H, Wennerberg J, Cavallin-Ståhl E. A systematic overview of radiation therapy effects in head and neck cancer. Acta Otolaryngol. 2003;42(5–6):443–61. doi:10.​1080/​0284186031001488​6.
10.
Zurück zum Zitat Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, Glisson B, et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med. 2003;349(22):2091–8. doi:10.1056/NEJMoa031317.PubMedCrossRef Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, Glisson B, et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med. 2003;349(22):2091–8. doi:10.​1056/​NEJMoa031317.PubMedCrossRef
11.
Zurück zum Zitat Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, Kish JA, et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med. 2004;350(19):1937–44. doi:10.1056/NEJMoa032646.PubMedCrossRef Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, Kish JA, et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med. 2004;350(19):1937–44. doi:10.​1056/​NEJMoa032646.PubMedCrossRef
12.
Zurück zum Zitat Al-Sarraf M, Leblanc M, Giri P, Fu K, Cooper J, Vuong T, Forastiere A, et al. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. J Clin Oncol. 1998;16(4):1310–7.PubMed Al-Sarraf M, Leblanc M, Giri P, Fu K, Cooper J, Vuong T, Forastiere A, et al. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. J Clin Oncol. 1998;16(4):1310–7.PubMed
13.
Zurück zum Zitat Adelstein DJ, Li Y, Adams GL, Wagner H, Kish JA, Ensley JF, Schuller DE, et al. An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol. 2003;21(1):92–8. doi:10.1200/jco.2003.01.008.PubMedCrossRef Adelstein DJ, Li Y, Adams GL, Wagner H, Kish JA, Ensley JF, Schuller DE, et al. An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol. 2003;21(1):92–8. doi:10.​1200/​jco.​2003.​01.​008.PubMedCrossRef
14.
Zurück zum Zitat Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, Jones CU, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006;354(6):567–78. doi:10.1056/NEJMoa053422.PubMedCrossRef Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, Jones CU, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006;354(6):567–78. doi:10.​1056/​NEJMoa053422.PubMedCrossRef
17.
Zurück zum Zitat Rosenthal DI, Mendoza TR, Chambers MS, Asper JA, Gning I, Kies MS, Weber RS, et al. Measuring head and neck cancer symptom burden: the development and validation of the M. D. Anderson symptom inventory, head and neck module. Head Neck. 2007;29(10):923–31. doi:10.1002/hed.20602.PubMedCrossRef Rosenthal DI, Mendoza TR, Chambers MS, Asper JA, Gning I, Kies MS, Weber RS, et al. Measuring head and neck cancer symptom burden: the development and validation of the M. D. Anderson symptom inventory, head and neck module. Head Neck. 2007;29(10):923–31. doi:10.​1002/​hed.​20602.PubMedCrossRef
19.
Zurück zum Zitat Trotti A, Bellm LA, Epstein JB, Frame D, Fuchs HJ, Gwede CK, Komaroff E, et al. Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review. Radiat Oncol. 2003;66(3):253–62. doi:10.1016/S0167-8140(02)00404-8.CrossRef Trotti A, Bellm LA, Epstein JB, Frame D, Fuchs HJ, Gwede CK, Komaroff E, et al. Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review. Radiat Oncol. 2003;66(3):253–62. doi:10.​1016/​S0167-8140(02)00404-8.CrossRef
20.
21.
Zurück zum Zitat Piquet M-A, Ozsahin M, Larpin I, Zouhair A, Coti P, Monney M, Monnier P, et al. Early nutritional intervention in oropharyngeal cancer patients undergoing radiotherapy. Support Care Cancer. 2002;10(6):502–4. doi:10.1007/s00520-002-0364-1.PubMedCrossRef Piquet M-A, Ozsahin M, Larpin I, Zouhair A, Coti P, Monney M, Monnier P, et al. Early nutritional intervention in oropharyngeal cancer patients undergoing radiotherapy. Support Care Cancer. 2002;10(6):502–4. doi:10.​1007/​s00520-002-0364-1.PubMedCrossRef
22.
Zurück zum Zitat Chen AM, Li B-Q, Lau DH, Farwell DG, Luu Q, Stuart K, Newman K, et al. Evaluating the role of prophylactic gastrostomy tube placement prior to definitive chemoradiotherapy for head and neck cancer. Int J Radiat Oncol Biol Phys. 2010;78(4):1026–32. doi:10.1016/j.ijrobp.2009.09.036.PubMedCrossRef Chen AM, Li B-Q, Lau DH, Farwell DG, Luu Q, Stuart K, Newman K, et al. Evaluating the role of prophylactic gastrostomy tube placement prior to definitive chemoradiotherapy for head and neck cancer. Int J Radiat Oncol Biol Phys. 2010;78(4):1026–32. doi:10.​1016/​j.​ijrobp.​2009.​09.​036.PubMedCrossRef
23.
Zurück zum Zitat Newman LA, Vieira F, Schwiezer V, Samant S, Murry T, Woodson G, Kumar P, et al. Eating and weight changes following chemoradiation therapy for advanced head and neck cancer. Arch Otolaryngol Head Neck Surg. 1998;124(5):589–92. doi:10.1001/archotol.124.5.589.PubMedCrossRef Newman LA, Vieira F, Schwiezer V, Samant S, Murry T, Woodson G, Kumar P, et al. Eating and weight changes following chemoradiation therapy for advanced head and neck cancer. Arch Otolaryngol Head Neck Surg. 1998;124(5):589–92. doi:10.​1001/​archotol.​124.​5.​589.PubMedCrossRef
25.
Zurück zum Zitat Colasanto JM, Prasad P, Nash MA, Decker RH, Wilson LD. Nutritional support of patients undergoing radiation therapy for head and neck cancer. Oncology. 2005;19(3):371–9.PubMed Colasanto JM, Prasad P, Nash MA, Decker RH, Wilson LD. Nutritional support of patients undergoing radiation therapy for head and neck cancer. Oncology. 2005;19(3):371–9.PubMed
26.
Zurück zum Zitat Lee JH, Machtay M, Unger LD, Weinstein GS, Weber RS, Chalian AA, Rosenthal DI. Prophylactic gastrostomy tubes in patients undergoing intensive irradiation for cancer of the head and neck. Arch Otolaryngol Head Neck Surg. 1998;124(8):871–5. doi:10.1001/archotol.124.8.871.PubMedCrossRef Lee JH, Machtay M, Unger LD, Weinstein GS, Weber RS, Chalian AA, Rosenthal DI. Prophylactic gastrostomy tubes in patients undergoing intensive irradiation for cancer of the head and neck. Arch Otolaryngol Head Neck Surg. 1998;124(8):871–5. doi:10.​1001/​archotol.​124.​8.​871.PubMedCrossRef
27.
Zurück zum Zitat Nayel H, El-Ghoneimy E, El-Haddad S. Impact of nutritional supplementation on treatment delay and morbidity in patients with head and neck tumors treated with irradiation. Nutrition. 1992;8(1):13–8.PubMed Nayel H, El-Ghoneimy E, El-Haddad S. Impact of nutritional supplementation on treatment delay and morbidity in patients with head and neck tumors treated with irradiation. Nutrition. 1992;8(1):13–8.PubMed
38.
Zurück zum Zitat Magné N, Marcy P, Foa C, Falewee M, Schneider M, Demard F, Bensadoun R. Comparison between nasogastric tube feeding and percutaneous fluoroscopic gastrostomy in advanced head and neck cancer patients. Eur Arch Otorhinolaryngol. 2001;258(2):89–92. doi:10.1007/s004050000311.PubMedCrossRef Magné N, Marcy P, Foa C, Falewee M, Schneider M, Demard F, Bensadoun R. Comparison between nasogastric tube feeding and percutaneous fluoroscopic gastrostomy in advanced head and neck cancer patients. Eur Arch Otorhinolaryngol. 2001;258(2):89–92. doi:10.​1007/​s004050000311.PubMedCrossRef
39.
Zurück zum Zitat Raykher A, Correa L, Russo L, Brown P, Lee N, Pfister D, Gerdes H, et al. The role of pretreatment percutaneous endoscopic gastrostomy in facilitating therapy of head and neck cancer and optimizing the body mass index of the obese patient. JPEN J Parenter Enteral Nutr. 2009;33(4):404–10. doi:10.1177/0148607108327525.PubMedCrossRef Raykher A, Correa L, Russo L, Brown P, Lee N, Pfister D, Gerdes H, et al. The role of pretreatment percutaneous endoscopic gastrostomy in facilitating therapy of head and neck cancer and optimizing the body mass index of the obese patient. JPEN J Parenter Enteral Nutr. 2009;33(4):404–10. doi:10.​1177/​0148607108327525​.PubMedCrossRef
41.
Zurück zum Zitat Nguyen N, Frank C, Moltz C, Vos P, Smith H, Nguyen P, Martinez T, et al. Analysis of factors influencing aspiration risk following chemoradiation for oropharyngeal cancer. Br J Radiol. 2009;82(980):675–80. doi:10.1259/bjr/72852974.PubMedCrossRef Nguyen N, Frank C, Moltz C, Vos P, Smith H, Nguyen P, Martinez T, et al. Analysis of factors influencing aspiration risk following chemoradiation for oropharyngeal cancer. Br J Radiol. 2009;82(980):675–80. doi:10.​1259/​bjr/​72852974.PubMedCrossRef
42.
Zurück zum Zitat Lee H, Havrila C, Bravo V, Shantz K, Diaz K, Larner J, Read P. Effect of oral nutritional supplementation on weight loss and percutaneous endoscopic gastrostomy tube rates in patients treated with radiotherapy for oropharyngeal carcinoma. Support Care Cancer. 2008;16(3):285–9. doi:10.1007/s00520-007-0313-0.PubMedCrossRef Lee H, Havrila C, Bravo V, Shantz K, Diaz K, Larner J, Read P. Effect of oral nutritional supplementation on weight loss and percutaneous endoscopic gastrostomy tube rates in patients treated with radiotherapy for oropharyngeal carcinoma. Support Care Cancer. 2008;16(3):285–9. doi:10.​1007/​s00520-007-0313-0.PubMedCrossRef
43.
Zurück zum Zitat Wiggenraad RGJ, Flierman L, Goossens A, Brand R, Verschuur HP, Croll GA, Moser LEC, et al. Prophylactic gastrostomy placement and early tube feeding may limit loss of weight during chemoradiotherapy for advanced head and neck cancer, a preliminary study. Clin Otolaryngol. 2007;32(5):384–90. doi:10.1111/j.1749-4486.2007.01533.x.PubMedCrossRef Wiggenraad RGJ, Flierman L, Goossens A, Brand R, Verschuur HP, Croll GA, Moser LEC, et al. Prophylactic gastrostomy placement and early tube feeding may limit loss of weight during chemoradiotherapy for advanced head and neck cancer, a preliminary study. Clin Otolaryngol. 2007;32(5):384–90. doi:10.​1111/​j.​1749-4486.​2007.​01533.​x.PubMedCrossRef
44.
Zurück zum Zitat Berlach DM, Nguyen N, Cury F, Al Halabi H, Shenouda G. Comparison of prophylactic and emergent percutaneous endoscopic gastrostomy tube placement in patients treated with chemotherapy and radiation for head and neck cancer. Int J Radiat Oncol Biol Phys. 2010;78(3 Suppl. 1):437.CrossRef Berlach DM, Nguyen N, Cury F, Al Halabi H, Shenouda G. Comparison of prophylactic and emergent percutaneous endoscopic gastrostomy tube placement in patients treated with chemotherapy and radiation for head and neck cancer. Int J Radiat Oncol Biol Phys. 2010;78(3 Suppl. 1):437.CrossRef
45.
Zurück zum Zitat Paccagnella A, Morello M, Da Mosto MC, Baruffi C, Marcon ML, Gava A, Baggio V, et al. Early nutritional intervention improves treatment tolerance and outcomes in head and neck cancer patients undergoing concurrent chemoradiotherapy. Support Care Cancer. 2010;18(7):837–45. doi:10.1007/s00520-009-0717-0.PubMedCrossRef Paccagnella A, Morello M, Da Mosto MC, Baruffi C, Marcon ML, Gava A, Baggio V, et al. Early nutritional intervention improves treatment tolerance and outcomes in head and neck cancer patients undergoing concurrent chemoradiotherapy. Support Care Cancer. 2010;18(7):837–45. doi:10.​1007/​s00520-009-0717-0.PubMedCrossRef
46.
Zurück zum Zitat Hughes BGM, Jain VK, Brown T, Spurgin A-L, Hartnett G, Keller J, Tripcony L, et al. Decreased hospital stay and significant cost savings after routine use of prophylactic gastrostomy for high-risk patients with head and neck cancer receiving chemoradiotherapy at a tertiary cancer institution. Head Neck. 2013;35(3):436–42. doi:10.1002/hed.22992.PubMedCrossRef Hughes BGM, Jain VK, Brown T, Spurgin A-L, Hartnett G, Keller J, Tripcony L, et al. Decreased hospital stay and significant cost savings after routine use of prophylactic gastrostomy for high-risk patients with head and neck cancer receiving chemoradiotherapy at a tertiary cancer institution. Head Neck. 2013;35(3):436–42. doi:10.​1002/​hed.​22992.PubMedCrossRef
47.
Zurück zum Zitat George A, Abhyankar A, Hari C. Percutaneous endoscopic gastrostomy (PEG) tube insertion in head and neck cancer (HNC) patients: a cause for delay. Otorhinolaryngologist. 2011;3(3):125–6. George A, Abhyankar A, Hari C. Percutaneous endoscopic gastrostomy (PEG) tube insertion in head and neck cancer (HNC) patients: a cause for delay. Otorhinolaryngologist. 2011;3(3):125–6.
49.
Zurück zum Zitat Moor JW, Patterson J, Kelly C, Paleri V. Prophylactic gastrostomy before chemoradiation in advanced head and neck cancer: a multiprofessional web-based survey to identify current practice and to analyse decision making. Clin Oncol. 2010;22(3):192–8. doi:10.1016/j.clon.2010.01.008.CrossRef Moor JW, Patterson J, Kelly C, Paleri V. Prophylactic gastrostomy before chemoradiation in advanced head and neck cancer: a multiprofessional web-based survey to identify current practice and to analyse decision making. Clin Oncol. 2010;22(3):192–8. doi:10.​1016/​j.​clon.​2010.​01.​008.CrossRef
50.
Zurück zum Zitat Back M, Raymond B, Ko F, Chin S, Veivers D, Wignall A, Eade T. Impact of prophylactic PEG tubes on nutritional outcomes at 12 months following IMRT for locoregionally advanced head and neck cancer. J Med Imaging Radiat Oncol. 2009;53:A199. Back M, Raymond B, Ko F, Chin S, Veivers D, Wignall A, Eade T. Impact of prophylactic PEG tubes on nutritional outcomes at 12 months following IMRT for locoregionally advanced head and neck cancer. J Med Imaging Radiat Oncol. 2009;53:A199.
56.
Zurück zum Zitat Sharma P, Berry S, Wilson K, Neale H, Fink A. Metastatic implantation of an oral squamous-cell carcinoma at a percutaneous endoscopic gastrostomy site. Surg Endosc. 1994;8(10):1232–5. doi:10.1007/BF00591059.PubMedCrossRef Sharma P, Berry S, Wilson K, Neale H, Fink A. Metastatic implantation of an oral squamous-cell carcinoma at a percutaneous endoscopic gastrostomy site. Surg Endosc. 1994;8(10):1232–5. doi:10.​1007/​BF00591059.PubMedCrossRef
58.
Zurück zum Zitat Schiano T, Pfister D, Harrison L, Shike M. Neoplastic seeding as a complication of percutaneous endoscopic gastrostomy. Am J Gastroenterol. 1994;89(1):131–3.PubMed Schiano T, Pfister D, Harrison L, Shike M. Neoplastic seeding as a complication of percutaneous endoscopic gastrostomy. Am J Gastroenterol. 1994;89(1):131–3.PubMed
59.
Zurück zum Zitat Schneider AM, Loggie BW. Metastatic head and neck cancer to the percutaneous endoscopic gastrostomy exit site: a case report and review of the literature. Am Surg. 1997;63(6):481.PubMed Schneider AM, Loggie BW. Metastatic head and neck cancer to the percutaneous endoscopic gastrostomy exit site: a case report and review of the literature. Am Surg. 1997;63(6):481.PubMed
60.
Zurück zum Zitat Riera L, Sandiumenge A, Calvo C, Bordas J, Alobid I, Llach J, Bernal M. Percutaneous endoscopic gastrostomy in head and neck cancer patients. J Otorhinolaryngol. 2002;64(1):32–4. doi:10.1159/000049265. Riera L, Sandiumenge A, Calvo C, Bordas J, Alobid I, Llach J, Bernal M. Percutaneous endoscopic gastrostomy in head and neck cancer patients. J Otorhinolaryngol. 2002;64(1):32–4. doi:10.​1159/​000049265.
61.
Zurück zum Zitat Corry J, Poon W, Mcphee N, Milner AD, Cruickshank D, Porceddu SV, Rischin D, et al. Prospective study of percutaneous endoscopic gastrostomy tubes versus nasogastric tubes for enteral feeding in patients with head and neck cancer undergoing (chemo)radiation. Head Neck. 2009;31(7):867–76. doi:10.1002/hed.21044.PubMedCrossRef Corry J, Poon W, Mcphee N, Milner AD, Cruickshank D, Porceddu SV, Rischin D, et al. Prospective study of percutaneous endoscopic gastrostomy tubes versus nasogastric tubes for enteral feeding in patients with head and neck cancer undergoing (chemo)radiation. Head Neck. 2009;31(7):867–76. doi:10.​1002/​hed.​21044.PubMedCrossRef
62.
Zurück zum Zitat Rustom IK, Jebreel A, Tayyab M, England RJA, Stafford ND. Percutaneous endoscopic, radiological and surgical gastrostomy tubes: a comparison study in head and neck cancer patients. J Laryngol Otol. 2006;120(6):463–6. doi:10.1017/S0022215106000661.PubMedCrossRef Rustom IK, Jebreel A, Tayyab M, England RJA, Stafford ND. Percutaneous endoscopic, radiological and surgical gastrostomy tubes: a comparison study in head and neck cancer patients. J Laryngol Otol. 2006;120(6):463–6. doi:10.​1017/​S002221510600066​1.PubMedCrossRef
63.
Zurück zum Zitat Grant D, Bradley P, Pothier D, Bailey D, Caldera S, Baldwin D, Birchall M. Complications following gastrostomy tube insertion in patients with head and neck cancer: a prospective multi-institution study, systematic review and meta-analysis. Clin Otolaryngol. 2009;34(2):103–12. doi:10.1111/j.1749-4486.2009.01889.x.PubMedCrossRef Grant D, Bradley P, Pothier D, Bailey D, Caldera S, Baldwin D, Birchall M. Complications following gastrostomy tube insertion in patients with head and neck cancer: a prospective multi-institution study, systematic review and meta-analysis. Clin Otolaryngol. 2009;34(2):103–12. doi:10.​1111/​j.​1749-4486.​2009.​01889.​x.PubMedCrossRef
66.
Zurück zum Zitat Madhoun MF, Blankenship MM, Blankenship DM, Krempl GA, Tierney WM. Prophylactic PEG placement in head and neck cancer: how many feeding tubes are unused (and unnecessary)? World J Gastroenterol. 2011;17(8):1004–1008. doi: 10.3748/wjg.v17.i8.1004 Madhoun MF, Blankenship MM, Blankenship DM, Krempl GA, Tierney WM. Prophylactic PEG placement in head and neck cancer: how many feeding tubes are unused (and unnecessary)? World J Gastroenterol. 2011;17(8):1004–1008. doi: 10.​3748/​wjg.​v17.​i8.​1004
68.
Zurück zum Zitat Carnaby-Mann G, Crary MA, Schmalfuss I, Amdur R. Pharyngocise: randomized controlled trial of preventative exercises to maintain muscle structure and swallowing function during head-and-neck chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2012;83(1):210–9. doi:10.1016/j.ijrobp.2011.06.1954.PubMedCrossRef Carnaby-Mann G, Crary MA, Schmalfuss I, Amdur R. Pharyngocise: randomized controlled trial of preventative exercises to maintain muscle structure and swallowing function during head-and-neck chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2012;83(1):210–9. doi:10.​1016/​j.​ijrobp.​2011.​06.​1954.PubMedCrossRef
70.
Zurück zum Zitat Robbins J, Butler SG, Daniels SK, Diez Gross R, Langmore S, Lazarus CL, Martin-Harris B, et al. Swallowing and dysphagia rehabilitation: translating principles of neural plasticity into clinically oriented evidence. J Speech Lang Hear Res. 2008;51(1):S276–300. doi:10.1044/1092-4388(2008/021).PubMedCrossRef Robbins J, Butler SG, Daniels SK, Diez Gross R, Langmore S, Lazarus CL, Martin-Harris B, et al. Swallowing and dysphagia rehabilitation: translating principles of neural plasticity into clinically oriented evidence. J Speech Lang Hear Res. 2008;51(1):S276–300. doi:10.​1044/​1092-4388(2008/​021).PubMedCrossRef
71.
Zurück zum Zitat Silander E, Jacobsson I, Berteus-Forslund H, Hammerlid E. Energy intake and sources of nutritional support in patients with head and neck cancer-a randomised longitudinal study. Eur J Clin Nutr. 2013;67(1):47–52. doi:10.1038/ejcn.2012.172.PubMedCrossRef Silander E, Jacobsson I, Berteus-Forslund H, Hammerlid E. Energy intake and sources of nutritional support in patients with head and neck cancer-a randomised longitudinal study. Eur J Clin Nutr. 2013;67(1):47–52. doi:10.​1038/​ejcn.​2012.​172.PubMedCrossRef
72.
Zurück zum Zitat Silander E, Nyman J, Bove M, Johansson L, Larsson S, Hammerlid E. Impact of prophylactic percutaneous endoscopic gastrostomy on malnutrition and quality of life in patients with head and neck cancer: a randomized study. Head Neck. 2012;34(1):1–9. doi:10.1002/hed.21700.PubMedCrossRef Silander E, Nyman J, Bove M, Johansson L, Larsson S, Hammerlid E. Impact of prophylactic percutaneous endoscopic gastrostomy on malnutrition and quality of life in patients with head and neck cancer: a randomized study. Head Neck. 2012;34(1):1–9. doi:10.​1002/​hed.​21700.PubMedCrossRef
73.
Zurück zum Zitat Langmore S, Vasquez Miloro K, Kriscuinas G. Prophylactic vs late PEG placement in head and neck cancer patients. Dysphagia. 2009;24(4):449.CrossRef Langmore S, Vasquez Miloro K, Kriscuinas G. Prophylactic vs late PEG placement in head and neck cancer patients. Dysphagia. 2009;24(4):449.CrossRef
75.
Zurück zum Zitat Locher JL, Bonner JA, Carroll WR, Caudell JJ, Keith JN, Kilgore ML, Ritchie CS, et al. Prophylactic percutaneous endoscopic gastrostomy tube placement in treatment of head and neck cancer: a comprehensive review and call for evidence-based medicine. JPEN J Parenter Enteral Nutr. 2011;35(3):365–74. doi:10.1177/0148607110377097.PubMedCrossRef Locher JL, Bonner JA, Carroll WR, Caudell JJ, Keith JN, Kilgore ML, Ritchie CS, et al. Prophylactic percutaneous endoscopic gastrostomy tube placement in treatment of head and neck cancer: a comprehensive review and call for evidence-based medicine. JPEN J Parenter Enteral Nutr. 2011;35(3):365–74. doi:10.​1177/​0148607110377097​.PubMedCrossRef
76.
Zurück zum Zitat Orphanidou C, Biggs K, Johnston M, Wright J, Bowman A, Hotte S, Esau A, et al. Prophylactic feeding tubes for patients with locally advanced head-and-neck cancer undergoing combined chemotherapy and radiotherapy: systematic review and recommendations for clinical practice. Curr Oncol. 2011;18(4):e191–201. doi:10.3747/co.v18i4.749.PubMedCentralPubMedCrossRef Orphanidou C, Biggs K, Johnston M, Wright J, Bowman A, Hotte S, Esau A, et al. Prophylactic feeding tubes for patients with locally advanced head-and-neck cancer undergoing combined chemotherapy and radiotherapy: systematic review and recommendations for clinical practice. Curr Oncol. 2011;18(4):e191–201. doi:10.​3747/​co.​v18i4.​749.PubMedCentralPubMedCrossRef
77.
Zurück zum Zitat Nugent B, Lewis S, O’sullivan JM. Enteral feeding methods for nutritional management in patients with head and neck cancers being treated with radiotherapy and/or chemotherapy. Cochrane Database Syst Rev. 2013;1:1–18. doi:10.1002/14651858.CD007904.pub3. Nugent B, Lewis S, O’sullivan JM. Enteral feeding methods for nutritional management in patients with head and neck cancers being treated with radiotherapy and/or chemotherapy. Cochrane Database Syst Rev. 2013;1:1–18. doi:10.​1002/​14651858.​CD007904.​pub3.
79.
80.
Zurück zum Zitat Higgins JPT, Altman DG. Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S, editors. Cochrane handbook for systematic reviews of interventions. Chichester: Wiley; 2008. p. 187–241.CrossRef Higgins JPT, Altman DG. Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S, editors. Cochrane handbook for systematic reviews of interventions. Chichester: Wiley; 2008. p. 187–241.CrossRef
81.
Zurück zum Zitat Berlach D, Nguyen NT, Al Halabi H, Cury F, Shenouda G. Comparison of prophylactic and urgent percutaneous gastrostomy tube placement in patients treated with combined radiation and chemotherapy for head and neck cancer. Radiother Oncol. 2010;96:S53. Berlach D, Nguyen NT, Al Halabi H, Cury F, Shenouda G. Comparison of prophylactic and urgent percutaneous gastrostomy tube placement in patients treated with combined radiation and chemotherapy for head and neck cancer. Radiother Oncol. 2010;96:S53.
82.
Zurück zum Zitat Romesser PT, Setton M, Schupak J, Gelblum K, Rao D, Sherman S, Lee E. Dysphagia quality of life scores and treatment outcomes in oropharyngeal cancer patients: is it time to reconsider the prophylactic percutaneous endoscopic gastrostomy? Int J Radiat Oncol Biol Phys. 2014;88(2):470.CrossRef Romesser PT, Setton M, Schupak J, Gelblum K, Rao D, Sherman S, Lee E. Dysphagia quality of life scores and treatment outcomes in oropharyngeal cancer patients: is it time to reconsider the prophylactic percutaneous endoscopic gastrostomy? Int J Radiat Oncol Biol Phys. 2014;88(2):470.CrossRef
84.
Zurück zum Zitat Quon HCM, Martens C, Butler A, Stimpson J, Duerksen R, Campbell-Enns D. Impact of feeding tubes on prospective functional outcomes in patients with locally-advanced head-and-neck cancer undergoing radiation therapy. Int J Radiat Oncol Biol Phys. 2013;87(2 Suppl. 1):S143.CrossRef Quon HCM, Martens C, Butler A, Stimpson J, Duerksen R, Campbell-Enns D. Impact of feeding tubes on prospective functional outcomes in patients with locally-advanced head-and-neck cancer undergoing radiation therapy. Int J Radiat Oncol Biol Phys. 2013;87(2 Suppl. 1):S143.CrossRef
86.
Zurück zum Zitat Chin S, Raymond B, Ko F, Eade T, Back M. Understanding the patient experience with prophylactic PEG tubes during intensity modulated radiation therapy for locoregionally advanced head and neck cancer. J Med Imaging Radiat Oncol. 2009;53:A100.CrossRef Chin S, Raymond B, Ko F, Eade T, Back M. Understanding the patient experience with prophylactic PEG tubes during intensity modulated radiation therapy for locoregionally advanced head and neck cancer. J Med Imaging Radiat Oncol. 2009;53:A100.CrossRef
87.
Zurück zum Zitat Romesser PB, Romanyshyn JC, Schupak KD, Setton J, Riaz N, Wolden SL, Gelblum DY, et al. Percutaneous endoscopic gastrostomy in oropharyngeal cancer patients treated with intensity-modulated radiotherapy with concurrent chemotherapy. Cancer. 2012;118(24):6072–8. doi:10.1002/cncr.27633.PubMedCrossRef Romesser PB, Romanyshyn JC, Schupak KD, Setton J, Riaz N, Wolden SL, Gelblum DY, et al. Percutaneous endoscopic gastrostomy in oropharyngeal cancer patients treated with intensity-modulated radiotherapy with concurrent chemotherapy. Cancer. 2012;118(24):6072–8. doi:10.​1002/​cncr.​27633.PubMedCrossRef
89.
90.
Zurück zum Zitat Olson R, Karam I, Wilson G, Bowman A, Lee C, Wong F. Population-based comparison of two feeding tube approaches for head and neck cancer patients receiving concurrent systemic-radiation therapy: is a prophylactic feeding tube approach harmful or helpful? Support Care Cancer. 2013;21(12):3433–9. doi:10.1007/s00520-013-1936-y.PubMedCrossRef Olson R, Karam I, Wilson G, Bowman A, Lee C, Wong F. Population-based comparison of two feeding tube approaches for head and neck cancer patients receiving concurrent systemic-radiation therapy: is a prophylactic feeding tube approach harmful or helpful? Support Care Cancer. 2013;21(12):3433–9. doi:10.​1007/​s00520-013-1936-y.PubMedCrossRef
91.
Zurück zum Zitat Rutter CE, Yovino S, Taylor R, Wolf J, Cullen KJ, Ord R, Athas M, et al. Impact of early percutaneous endoscopic gastrostomy tube placement on nutritional status and hospitalization in patients with head and neck cancer receiving definitive chemoradiation therapy. Head Neck. 2011;33(10):1441–7. doi:10.1002/hed.21624.PubMedCrossRef Rutter CE, Yovino S, Taylor R, Wolf J, Cullen KJ, Ord R, Athas M, et al. Impact of early percutaneous endoscopic gastrostomy tube placement on nutritional status and hospitalization in patients with head and neck cancer receiving definitive chemoradiation therapy. Head Neck. 2011;33(10):1441–7. doi:10.​1002/​hed.​21624.PubMedCrossRef
92.
Zurück zum Zitat Prestwich RJD, Teo MTW, Gilbert A, Williams G, Dyker KE, Sen M. Long-term swallow function after chemoradiotherapy for oropharyngeal cancer: the influence of a prophylactic gastrostomy or reactive nasogastric tube. Clin Oncol. 2014;26(2):103–9. doi:10.1016/j.clon.2013.10.005.CrossRef Prestwich RJD, Teo MTW, Gilbert A, Williams G, Dyker KE, Sen M. Long-term swallow function after chemoradiotherapy for oropharyngeal cancer: the influence of a prophylactic gastrostomy or reactive nasogastric tube. Clin Oncol. 2014;26(2):103–9. doi:10.​1016/​j.​clon.​2013.​10.​005.CrossRef
93.
Zurück zum Zitat Romesser PB, Tam MM, Zhang Z, Setton J, Spratt DE, Schupak KD, Gelblum DY, et al. Prospective dysphagia quality of life scores and treatment outcomes in oropharyngeal cancer patients: is it time to reconsider the prophylactic percutaneous endoscopic gastrostomy? Int J Radiat Oncol Biol Phys. 2013;87(2 Suppl. 1):S131.CrossRef Romesser PB, Tam MM, Zhang Z, Setton J, Spratt DE, Schupak KD, Gelblum DY, et al. Prospective dysphagia quality of life scores and treatment outcomes in oropharyngeal cancer patients: is it time to reconsider the prophylactic percutaneous endoscopic gastrostomy? Int J Radiat Oncol Biol Phys. 2013;87(2 Suppl. 1):S131.CrossRef
94.
95.
Zurück zum Zitat Pohar SS, Demarcantonio M, Crandley E, Wadsworth JT, Karakla D. Prophylactic PEG tube and swallowing following chemoradiation. Int J Radiat Oncol Biol Phys. 2010;78(3 Suppl. 1):S456.CrossRef Pohar SS, Demarcantonio M, Crandley E, Wadsworth JT, Karakla D. Prophylactic PEG tube and swallowing following chemoradiation. Int J Radiat Oncol Biol Phys. 2010;78(3 Suppl. 1):S456.CrossRef
96.
Zurück zum Zitat Chen AM, Chen LM, Vaughan A, Farwell DG, Luu Q, Purdy JA, Vijayakumar S. Head and neck cancer among lifelong never-smokers and ever-smokers: matched-pair analysis of outcomes after radiation therapy. Am J Clin Oncol. 2010;34(3):270–5. doi:10.1097/COC.0b013e3181dea40b.CrossRef Chen AM, Chen LM, Vaughan A, Farwell DG, Luu Q, Purdy JA, Vijayakumar S. Head and neck cancer among lifelong never-smokers and ever-smokers: matched-pair analysis of outcomes after radiation therapy. Am J Clin Oncol. 2010;34(3):270–5. doi:10.​1097/​COC.​0b013e3181dea40b​.CrossRef
97.
Zurück zum Zitat Tracy JF, Logemann JA, Kahrilas PJ, Jacob P, Kobara M, Krugler C. Preliminary observations on the effects of age on oropharyngeal deglutition. Dysphagia. 1989;4(2):90–4. doi:10.1007/BF02407151.PubMedCrossRef Tracy JF, Logemann JA, Kahrilas PJ, Jacob P, Kobara M, Krugler C. Preliminary observations on the effects of age on oropharyngeal deglutition. Dysphagia. 1989;4(2):90–4. doi:10.​1007/​BF02407151.PubMedCrossRef
98.
Zurück zum Zitat Ekberg O, Feinberg M. Altered swallowing function in elderly patients without dysphagia: radiologic findings in 56 cases. Am J Roentgenol. 1991;156(6):1181–4.CrossRef Ekberg O, Feinberg M. Altered swallowing function in elderly patients without dysphagia: radiologic findings in 56 cases. Am J Roentgenol. 1991;156(6):1181–4.CrossRef
99.
Zurück zum Zitat Jager-Wittenaar HT, Dijkstra PU, Vissink A, Van Der Laan BF, Van Oort RP, Roodenburg JL. Critical weight loss in head and neck cancer-prevalence and risk factors at diagnosis: an explorative study. Support Care Cancer. 2007;15(9):1045–50. doi:10.1007/s00520-006-0212-9.PubMedCrossRef Jager-Wittenaar HT, Dijkstra PU, Vissink A, Van Der Laan BF, Van Oort RP, Roodenburg JL. Critical weight loss in head and neck cancer-prevalence and risk factors at diagnosis: an explorative study. Support Care Cancer. 2007;15(9):1045–50. doi:10.​1007/​s00520-006-0212-9.PubMedCrossRef
100.
Zurück zum Zitat Caudell JJ, Schaner PE, Meredith RF, Locher JL, Nabell LM, Carroll WR, Magnuson JS, et al. Factors associated with long-term dysphagia after definitive radiotherapy for locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2009;73(2):410–5. doi:10.1016/j.ijrobp.2008.04.048.PubMedCrossRef Caudell JJ, Schaner PE, Meredith RF, Locher JL, Nabell LM, Carroll WR, Magnuson JS, et al. Factors associated with long-term dysphagia after definitive radiotherapy for locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2009;73(2):410–5. doi:10.​1016/​j.​ijrobp.​2008.​04.​048.PubMedCrossRef
101.
Zurück zum Zitat Dirix P, Abbeel S, Vanstraelen B, Hermans R, Nuyts S. Dysphagia after chemoradiotherapy for head-and-neck squamous cell carcinoma: dose-effect relationships for the swallowing structures. Int J Radiat Oncol Biol Phys. 2009;75(2):385–92. doi:10.1016/j.ijrobp.2008.11.041.PubMedCrossRef Dirix P, Abbeel S, Vanstraelen B, Hermans R, Nuyts S. Dysphagia after chemoradiotherapy for head-and-neck squamous cell carcinoma: dose-effect relationships for the swallowing structures. Int J Radiat Oncol Biol Phys. 2009;75(2):385–92. doi:10.​1016/​j.​ijrobp.​2008.​11.​041.PubMedCrossRef
102.
Zurück zum Zitat Machtay M, Moughan J, Trotti A, Garden AS, Weber RS, Cooper JS, Forastiere A, et al. Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol. 2008;26(21):3582–9. doi:10.1200/jco.2007.14.8841.PubMedCrossRef Machtay M, Moughan J, Trotti A, Garden AS, Weber RS, Cooper JS, Forastiere A, et al. Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol. 2008;26(21):3582–9. doi:10.​1200/​jco.​2007.​14.​8841.PubMedCrossRef
104.
Zurück zum Zitat Pildal J, Hróbjartsson A, Jørgensen K, Hilden J, Altman D, Gøtzsche P. Impact of allocation concealment on conclusions drawn from meta-analyses of randomized trials. Int J Epidemiol. 2007;36(4):847–57. doi:10.1093/ije/dym087.PubMedCrossRef Pildal J, Hróbjartsson A, Jørgensen K, Hilden J, Altman D, Gøtzsche P. Impact of allocation concealment on conclusions drawn from meta-analyses of randomized trials. Int J Epidemiol. 2007;36(4):847–57. doi:10.​1093/​ije/​dym087.PubMedCrossRef
110.
Zurück zum Zitat Logemann JA, Rademaker AW, Pauloski BR, Lazarus CL, Mittal BB, Brockstein B, Maccracken E, et al. Site of disease and treatment protocol as correlates of swallowing function in patients with head and neck cancer treated with chemoradiation. Head Neck. 2006;28(1):64–73. doi:10.1002/hed.20299.PubMedCentralPubMedCrossRef Logemann JA, Rademaker AW, Pauloski BR, Lazarus CL, Mittal BB, Brockstein B, Maccracken E, et al. Site of disease and treatment protocol as correlates of swallowing function in patients with head and neck cancer treated with chemoradiation. Head Neck. 2006;28(1):64–73. doi:10.​1002/​hed.​20299.PubMedCentralPubMedCrossRef
111.
Zurück zum Zitat Lowery SD. Assessment and measurement tools used in the evaluation of swallowing. Curr Opin Otolaryngol Head Neck Surg. 2001;9(3):134–8.CrossRef Lowery SD. Assessment and measurement tools used in the evaluation of swallowing. Curr Opin Otolaryngol Head Neck Surg. 2001;9(3):134–8.CrossRef
112.
Zurück zum Zitat Eisbruch A, Lyden T, Bradford CR, Dawson LA, Haxer MJ, Miller AE, Teknos TN, et al. Objective assessment of swallowing dysfunction and aspiration after radiation concurrent with chemotherapy for head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2002;53(1):23–8. doi:10.1016/S0360-3016(02)02712-8.PubMedCrossRef Eisbruch A, Lyden T, Bradford CR, Dawson LA, Haxer MJ, Miller AE, Teknos TN, et al. Objective assessment of swallowing dysfunction and aspiration after radiation concurrent with chemotherapy for head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2002;53(1):23–8. doi:10.​1016/​S0360-3016(02)02712-8.PubMedCrossRef
113.
Zurück zum Zitat Jensen K, Bonde Jensen A, Grau C. The relationship between observer-based toxicity scoring and patient assessed symptom severity after treatment for head and neck cancer. A correlative cross sectional study of the DAHANCA toxicity scoring system and the EORTC quality of life questionnaires. Radiother Oncol. 2006;78(3):298–305. doi:10.1016/j.radonc.2006.02.005.PubMedCrossRef Jensen K, Bonde Jensen A, Grau C. The relationship between observer-based toxicity scoring and patient assessed symptom severity after treatment for head and neck cancer. A correlative cross sectional study of the DAHANCA toxicity scoring system and the EORTC quality of life questionnaires. Radiother Oncol. 2006;78(3):298–305. doi:10.​1016/​j.​radonc.​2006.​02.​005.PubMedCrossRef
114.
115.
118.
Zurück zum Zitat Amin N, Reddy K, Westerly D, Raben D, Dewitt P, Chen C. Sparing the larynx and esophageal inlet expedites feeding tube removal in patients with stage III–IV oropharyngeal squamous cell carcinoma treated with intensity-modulated radiotherapy. Laryngoscope. 2012;122(12):2736–42. doi:10.1002/lary.23597.PubMedCrossRef Amin N, Reddy K, Westerly D, Raben D, Dewitt P, Chen C. Sparing the larynx and esophageal inlet expedites feeding tube removal in patients with stage III–IV oropharyngeal squamous cell carcinoma treated with intensity-modulated radiotherapy. Laryngoscope. 2012;122(12):2736–42. doi:10.​1002/​lary.​23597.PubMedCrossRef
119.
Zurück zum Zitat Bhayani MK, Hutcheson KA, Barringer DA, Lisec A, Alvarez CP, Roberts DB, Lai SY, et al. Gastrostomy tube placement in patients with oropharyngeal carcinoma treated with radiotherapy or chemoradiotherapy: factors affecting placement and dependence. 2013;35(11):1634–40. doi:10.1002/hed.23200. Bhayani MK, Hutcheson KA, Barringer DA, Lisec A, Alvarez CP, Roberts DB, Lai SY, et al. Gastrostomy tube placement in patients with oropharyngeal carcinoma treated with radiotherapy or chemoradiotherapy: factors affecting placement and dependence. 2013;35(11):1634–40. doi:10.​1002/​hed.​23200.
120.
Zurück zum Zitat Bhayani MK, Hutcheson KA, Barringer DA, Roberts DB, Lewin JS, Lai SY. Gastrostomy tube placement in patients with hypopharyngeal cancer treated with radiotherapy or chemoradiotherapy: factors affecting placement and dependence. 2013;35(11):1641–46. doi:10.1002/hed.23199. Bhayani MK, Hutcheson KA, Barringer DA, Roberts DB, Lewin JS, Lai SY. Gastrostomy tube placement in patients with hypopharyngeal cancer treated with radiotherapy or chemoradiotherapy: factors affecting placement and dependence. 2013;35(11):1641–46. doi:10.​1002/​hed.​23199.
121.
Zurück zum Zitat Magnuson JS, Durst J, Rosenthal EL, Carroll WR, Ritchie CS, Kilgore ML, Locher JL. Increased likelihood of long-term gastrostomy tube dependence in head and neck cancer survivors without partners. Head Neck. 2013;35(3):420–5. doi:10.1002/hed.22996.PubMedCentralPubMedCrossRef Magnuson JS, Durst J, Rosenthal EL, Carroll WR, Ritchie CS, Kilgore ML, Locher JL. Increased likelihood of long-term gastrostomy tube dependence in head and neck cancer survivors without partners. Head Neck. 2013;35(3):420–5. doi:10.​1002/​hed.​22996.PubMedCentralPubMedCrossRef
122.
Zurück zum Zitat Kiss NK, Krishnasamy M, Loeliger J, Granados A, Dutu G, Corry J. A dietitian-led clinic for patients receiving (chemo)radiotherapy for head and neck cancer. Support Care Cancer. 2012;20(9):2111–20. doi:10.1007/s00520-011-1321-7.PubMedCrossRef Kiss NK, Krishnasamy M, Loeliger J, Granados A, Dutu G, Corry J. A dietitian-led clinic for patients receiving (chemo)radiotherapy for head and neck cancer. Support Care Cancer. 2012;20(9):2111–20. doi:10.​1007/​s00520-011-1321-7.PubMedCrossRef
123.
Zurück zum Zitat Bjordal K, Hammerlid E, Ahlner-Elmqvist M, De Graeff A, Boysen M, Evensen JF, Biörklund A, et al. Quality of life in head and neck cancer patients: validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-H&N35. J Clin Oncol. 1999;17(3):1008.PubMed Bjordal K, Hammerlid E, Ahlner-Elmqvist M, De Graeff A, Boysen M, Evensen JF, Biörklund A, et al. Quality of life in head and neck cancer patients: validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-H&N35. J Clin Oncol. 1999;17(3):1008.PubMed
Metadaten
Titel
The Effect of Prophylactic Percutaneous Endoscopic Gastrostomy (PEG) Tube Placement on Swallowing and Swallow-Related Outcomes in Patients Undergoing Radiotherapy for Head and Neck Cancer: A Systematic Review
verfasst von
Stephanie M. Shaw
Heather Flowers
Brian O’Sullivan
Andrew Hope
Louis W. C. Liu
Rosemary Martino
Publikationsdatum
01.04.2015
Verlag
Springer US
Erschienen in
Dysphagia / Ausgabe 2/2015
Print ISSN: 0179-051X
Elektronische ISSN: 1432-0460
DOI
https://doi.org/10.1007/s00455-014-9592-z

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