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Erschienen in: Surgical Endoscopy 11/2013

01.11.2013

Retrospective study of endoscopic submucosal tunnel dissection (ESTD) for surgical resection of esophageal leiomyoma

verfasst von: Lei Wang, Wei Ren, Zhimei Zhang, Jing Yu, Yihui Li, Yuankun Song

Erschienen in: Surgical Endoscopy | Ausgabe 11/2013

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Abstract

Background

Esophageal leiomyoma is benign and often asymptomatic, but if the tumor is too large or obstructive, it should be resected. The aim of this study was to compare a novel approach, endoscopic submucosal tunnel dissection (ESTD), with a more established method, endoscopic submucosal dissection (ESD).

Methods

This was a retrospective study of 39 patients in Chongqing Xinqiao Hospital, China, undergoing resection for leiomyoma >2 cm in diameter, or 1.5–2.0 cm in diameter with symptoms of obstructive dysphagia. Epidemiological data, presenting symptoms, diagnostic investigations, tumor location, histopathological findings, and safety and efficacy of surgical resection were analyzed.

Results

Mean tumor sizes in the ESTD (n = 18; mean age = 36.7 ± 6.3 years) and ESD (n = 21; age = 41.0 ± 4.4 years) groups were 3.3 ± 0.7 and 3.0 ± 0.4 cm, respectively. The male:female ratio was 25:14, with a distribution of lesions among the lower, middle, and upper esophagus of 22:14:3. Operating time was significantly shorter (p < 0.05) for ESTD (67.5 ± 9.5 min) than for ESD (87.2 ± 7.7 min), while incision healing was faster (p < 0.05) for ESTD (14.7 ± 2.5 days) than for ESD (57.9 ± 7.5 days). Hospital stay was also shorter (p < 0.05) for ESTD (2.3 ± 0.5 days) than for ESD (5.7 ± 1.0 days). Bleeding was the only complication with ESTD (3/18 patients), with no significant difference in the incidence of complications between groups. ESTD was rapidly learned by surgeons.

Conclusion

ESTD is a safe and effective treatment for esophageal leiomyoma, with advantages over ESD.
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Literatur
1.
Zurück zum Zitat Punpale A, Rangole A, Bhambhani N, Karimundackal G, Desai N, de Souza A, Pramesh CS, Jambhekar N, Mistry RC (2007) Leiomyoma of esophagus. Ann Thorac Cardiovasc Surg 13:78–81PubMed Punpale A, Rangole A, Bhambhani N, Karimundackal G, Desai N, de Souza A, Pramesh CS, Jambhekar N, Mistry RC (2007) Leiomyoma of esophagus. Ann Thorac Cardiovasc Surg 13:78–81PubMed
2.
Zurück zum Zitat Luh SP, Hou SM, Fang CC, Chen CY (2012) Video-thoracoscopic enucleation of esophageal leiomyoma. World J Surg Oncol 10:52PubMedCrossRef Luh SP, Hou SM, Fang CC, Chen CY (2012) Video-thoracoscopic enucleation of esophageal leiomyoma. World J Surg Oncol 10:52PubMedCrossRef
3.
Zurück zum Zitat Seremetis MG, Lyons WS, deGuzman VC, Peabody JW Jr (1976) Leiomyomata of the esophagus. An analysis of 838 cases. Cancer 38:2166–2177PubMedCrossRef Seremetis MG, Lyons WS, deGuzman VC, Peabody JW Jr (1976) Leiomyomata of the esophagus. An analysis of 838 cases. Cancer 38:2166–2177PubMedCrossRef
4.
Zurück zum Zitat Mutrie CJ, Donahue DM, Wain JC, Wright CD, Gaissert HA, Grillo HC, Mathisen DJ, Allan JS (2005) Esophageal leiomyoma: a 40-year experience. Ann Thorac Surg 79:1122–1125PubMedCrossRef Mutrie CJ, Donahue DM, Wain JC, Wright CD, Gaissert HA, Grillo HC, Mathisen DJ, Allan JS (2005) Esophageal leiomyoma: a 40-year experience. Ann Thorac Surg 79:1122–1125PubMedCrossRef
5.
Zurück zum Zitat Asteriou C, Konstantinou D, Lalountas M, Kleontas A, Setzis K, Zafiriou G, Barbetakis N (2009) Nine years experience in surgical approach of leiomyomatosis of esophagus. World J Surg Oncol 7:102PubMedCrossRef Asteriou C, Konstantinou D, Lalountas M, Kleontas A, Setzis K, Zafiriou G, Barbetakis N (2009) Nine years experience in surgical approach of leiomyomatosis of esophagus. World J Surg Oncol 7:102PubMedCrossRef
8.
Zurück zum Zitat Bonavina L, Segalin A, Rosati R, Pavanello M, Peracchia A (1995) Surgical therapy of esophageal leiomyoma. J Am Coll Surg 181:257–262PubMed Bonavina L, Segalin A, Rosati R, Pavanello M, Peracchia A (1995) Surgical therapy of esophageal leiomyoma. J Am Coll Surg 181:257–262PubMed
9.
Zurück zum Zitat Wang Y, Zhang R, Ouyang Z, Zhang D, Wang L (2002) Diagnosis and surgical treatment of esophageal leiomyoma. Zhonghua Zhong Liu Za Zhi 24:394–396PubMed Wang Y, Zhang R, Ouyang Z, Zhang D, Wang L (2002) Diagnosis and surgical treatment of esophageal leiomyoma. Zhonghua Zhong Liu Za Zhi 24:394–396PubMed
10.
Zurück zum Zitat Jiang W, Rice TW, Goldblum JR (2012) Esophageal leiomyoma: experience from a single institution. Dis Esophagus 26:167–174PubMedCrossRef Jiang W, Rice TW, Goldblum JR (2012) Esophageal leiomyoma: experience from a single institution. Dis Esophagus 26:167–174PubMedCrossRef
11.
Zurück zum Zitat Kantsevoy SV, Adler DG, Conway JD, Diehl DL, Farraye FA, Kwon R, Mamula P, Rodriguez S, Shah RJ, Wong Kee Song LM, Tierney WM (2008) Endoscopic mucosal resection and endoscopic submucosal dissection. Gastrointest Endosc 68:11–18PubMedCrossRef Kantsevoy SV, Adler DG, Conway JD, Diehl DL, Farraye FA, Kwon R, Mamula P, Rodriguez S, Shah RJ, Wong Kee Song LM, Tierney WM (2008) Endoscopic mucosal resection and endoscopic submucosal dissection. Gastrointest Endosc 68:11–18PubMedCrossRef
12.
Zurück zum Zitat Sun X, Wang J, Yang G (2012) Surgical treatment of esophageal leiomyoma larger than 5 cm in diameter: A case report and review of the literature. J Thorac Dis 4:323–326PubMedCrossRef Sun X, Wang J, Yang G (2012) Surgical treatment of esophageal leiomyoma larger than 5 cm in diameter: A case report and review of the literature. J Thorac Dis 4:323–326PubMedCrossRef
13.
Zurück zum Zitat Rendina EA, Venuta F, Pescarmona EO, Facciolo F, Francioni F, Di Tolla R, Ricci C (1990) Leiomyoma of the esophagus. Scand J Thorac Cardiovasc Surg 24:79–82PubMedCrossRef Rendina EA, Venuta F, Pescarmona EO, Facciolo F, Francioni F, Di Tolla R, Ricci C (1990) Leiomyoma of the esophagus. Scand J Thorac Cardiovasc Surg 24:79–82PubMedCrossRef
14.
Zurück zum Zitat Samphire J, Nafteux P, Luketich J (2003) Minimally invasive techniques for resection of benign esophageal tumors. Semin Thorac Cardiovasc Surg 15:35–43PubMedCrossRef Samphire J, Nafteux P, Luketich J (2003) Minimally invasive techniques for resection of benign esophageal tumors. Semin Thorac Cardiovasc Surg 15:35–43PubMedCrossRef
15.
Zurück zum Zitat Priego P, Lobo E, Alonso N, Gil Olarte MA, Perez de Oteyza J, Fresneda V (2006) Surgical treatment of esophageal leiomyoma: an analysis of our experience. Rev Esp Enferm Dig 98:350–358PubMed Priego P, Lobo E, Alonso N, Gil Olarte MA, Perez de Oteyza J, Fresneda V (2006) Surgical treatment of esophageal leiomyoma: an analysis of our experience. Rev Esp Enferm Dig 98:350–358PubMed
16.
Zurück zum Zitat Zaninotto G, Portale G, Costantini M, Rizzetto C, Salvador R, Rampado S, Pennelli G, Ancona E (2006) Minimally invasive enucleation of esophageal leiomyoma. Surg Endosc 20:1904–1908PubMedCrossRef Zaninotto G, Portale G, Costantini M, Rizzetto C, Salvador R, Rampado S, Pennelli G, Ancona E (2006) Minimally invasive enucleation of esophageal leiomyoma. Surg Endosc 20:1904–1908PubMedCrossRef
17.
Zurück zum Zitat Kent M, d’Amato T, Nordman C, Schuchert M, Landreneau R, Alvelo-Rivera M, Luketich J (2007) Minimally invasive resection of benign esophageal tumors. J Thorac Cardiovasc Surg 134:176–181PubMedCrossRef Kent M, d’Amato T, Nordman C, Schuchert M, Landreneau R, Alvelo-Rivera M, Luketich J (2007) Minimally invasive resection of benign esophageal tumors. J Thorac Cardiovasc Surg 134:176–181PubMedCrossRef
18.
Zurück zum Zitat Nguyen NT, Reavis KM, El-Badawi K, Hinojosa MW, Smith BR (2008) Minimally invasive surgical enucleation or esophagogastrectomy for benign tumor of the esophagus. Surg Innov 15:120–125PubMedCrossRef Nguyen NT, Reavis KM, El-Badawi K, Hinojosa MW, Smith BR (2008) Minimally invasive surgical enucleation or esophagogastrectomy for benign tumor of the esophagus. Surg Innov 15:120–125PubMedCrossRef
19.
Zurück zum Zitat Palanivelu C, Rangarajan M, Madankumar MV, John SJ, Senthilkumar R (2008) Minimally invasive therapy for benign tumors of the distal third of the esophagus–a single institute’s experience. J Laparoendosc Adv Surg Tech A 18:20–26PubMedCrossRef Palanivelu C, Rangarajan M, Madankumar MV, John SJ, Senthilkumar R (2008) Minimally invasive therapy for benign tumors of the distal third of the esophagus–a single institute’s experience. J Laparoendosc Adv Surg Tech A 18:20–26PubMedCrossRef
20.
Zurück zum Zitat Jiang G, Zhao H, Yang F, Li J, Li Y, Liu Y, Liu J, Wang J (2009) Thoracoscopic enucleation of esophageal leiomyoma: a retrospective study on 40 cases. Dis Esophagus 22:279–283PubMedCrossRef Jiang G, Zhao H, Yang F, Li J, Li Y, Liu Y, Liu J, Wang J (2009) Thoracoscopic enucleation of esophageal leiomyoma: a retrospective study on 40 cases. Dis Esophagus 22:279–283PubMedCrossRef
21.
Zurück zum Zitat Li ZG, Chen HZ, Jin H, Yang LX, Xu ZY, Liu F, Yao F (2009) Surgical treatment of esophageal leiomyoma located near or at the esophagogastric junction via a thoracoscopic approach. Dis Esophagus 22:185–189PubMedCrossRef Li ZG, Chen HZ, Jin H, Yang LX, Xu ZY, Liu F, Yao F (2009) Surgical treatment of esophageal leiomyoma located near or at the esophagogastric junction via a thoracoscopic approach. Dis Esophagus 22:185–189PubMedCrossRef
22.
Zurück zum Zitat Obuchi T, Sasaki A, Nitta H, Koeda K, Ikeda K, Wakabayashi G (2010) Minimally invasive surgical enucleation for esophageal leiomyoma: report of seven cases. Dis Esophagus 23:E1–E4PubMedCrossRef Obuchi T, Sasaki A, Nitta H, Koeda K, Ikeda K, Wakabayashi G (2010) Minimally invasive surgical enucleation for esophageal leiomyoma: report of seven cases. Dis Esophagus 23:E1–E4PubMedCrossRef
23.
Zurück zum Zitat Chiu PW, Lee YT, Ng EK (2006) Resection of esophageal leiomyoma using an endoscopic submucosal dissection technique. Endoscopy 38(Suppl 2):E4PubMedCrossRef Chiu PW, Lee YT, Ng EK (2006) Resection of esophageal leiomyoma using an endoscopic submucosal dissection technique. Endoscopy 38(Suppl 2):E4PubMedCrossRef
24.
Zurück zum Zitat Koike Y, Obana T, Fujita N, Hirasawa D, Suzuki T, Sugawara T, Ohira T, Harada Y, Maeda Y, Suzuki K, Yamagata T, Noda Y, Oikawa M, Sawai T (2010) A case of giant esophageal leiomyoma successfully resected by endoscopic submucosal dissection followed by retrieval via laparotomy. Nihon Shokakibyo Gakkai Zasshi 107:1780–1785PubMed Koike Y, Obana T, Fujita N, Hirasawa D, Suzuki T, Sugawara T, Ohira T, Harada Y, Maeda Y, Suzuki K, Yamagata T, Noda Y, Oikawa M, Sawai T (2010) A case of giant esophageal leiomyoma successfully resected by endoscopic submucosal dissection followed by retrieval via laparotomy. Nihon Shokakibyo Gakkai Zasshi 107:1780–1785PubMed
25.
Zurück zum Zitat Jun W, Lu H, Lilin F, Ping L, Li L, Qingjun Y, Dongfeng C (2011) Endoscopic submucosal dissection for treating esophageal leiomyoma as in 40 cases. Chongqing Med 14–18 Jun W, Lu H, Lilin F, Ping L, Li L, Qingjun Y, Dongfeng C (2011) Endoscopic submucosal dissection for treating esophageal leiomyoma as in 40 cases. Chongqing Med 14–18
26.
Zurück zum Zitat Xu MD, Cai MY, Zhou PH, Qin XY, Zhong YS, Chen WF, Hu JW, Zhang YQ, Ma LL, Qin WZ, Yao LQ (2012) Submucosal tunneling endoscopic resection: a new technique for treating upper GI submucosal tumors originating from the muscularis propria layer (with videos). Gastrointest Endosc 75:195–199PubMedCrossRef Xu MD, Cai MY, Zhou PH, Qin XY, Zhong YS, Chen WF, Hu JW, Zhang YQ, Ma LL, Qin WZ, Yao LQ (2012) Submucosal tunneling endoscopic resection: a new technique for treating upper GI submucosal tumors originating from the muscularis propria layer (with videos). Gastrointest Endosc 75:195–199PubMedCrossRef
27.
Zurück zum Zitat Ye LP, Zhang Y, Mao XL, Zhu LH, Zhou XB, He SQ, Chen JY, Jin X (2012) Submucosal tunnelling endoscopic resection for the treatment of esophageal submucosal tumours originating from the muscularis propria layer: an analysis of 15 cases. Dig Liver Dis 45:119–123PubMedCrossRef Ye LP, Zhang Y, Mao XL, Zhu LH, Zhou XB, He SQ, Chen JY, Jin X (2012) Submucosal tunnelling endoscopic resection for the treatment of esophageal submucosal tumours originating from the muscularis propria layer: an analysis of 15 cases. Dig Liver Dis 45:119–123PubMedCrossRef
28.
Zurück zum Zitat Cai M, Chen J, Zhou P, Yao L (2012) The rise of tunnel endoscopic surgery: a case report and literature review. Case Rep Gastrointest Med 2012:847640PubMed Cai M, Chen J, Zhou P, Yao L (2012) The rise of tunnel endoscopic surgery: a case report and literature review. Case Rep Gastrointest Med 2012:847640PubMed
29.
Zurück zum Zitat Gong W, Xiong Y, Zhi F, Liu S, Wang A, Jiang B (2012) Preliminary experience of endoscopic submucosal tunnel dissection for upper gastrointestinal submucosal tumors. Endoscopy 44:231–235PubMedCrossRef Gong W, Xiong Y, Zhi F, Liu S, Wang A, Jiang B (2012) Preliminary experience of endoscopic submucosal tunnel dissection for upper gastrointestinal submucosal tumors. Endoscopy 44:231–235PubMedCrossRef
30.
Zurück zum Zitat Inoue H, Ikeda H, Hosoya T, Onimaru M, Yoshida A, Eleftheriadis N, Maselli R, Kudo S (2012) Submucosal endoscopic tumor resection for subepithelial tumors in the esophagus and cardia. Endoscopy 44:225–230PubMedCrossRef Inoue H, Ikeda H, Hosoya T, Onimaru M, Yoshida A, Eleftheriadis N, Maselli R, Kudo S (2012) Submucosal endoscopic tumor resection for subepithelial tumors in the esophagus and cardia. Endoscopy 44:225–230PubMedCrossRef
31.
Zurück zum Zitat Wang L, Fan CQ, Ren W, Zhang X, Li YH, Zhao XY (2011) Endoscopic dissection of large endogenous myogenic tumors in the esophagus and stomach is safe and feasible: a report of 42 cases. Scand J Gastroenterol 46:627–633PubMedCrossRef Wang L, Fan CQ, Ren W, Zhang X, Li YH, Zhao XY (2011) Endoscopic dissection of large endogenous myogenic tumors in the esophagus and stomach is safe and feasible: a report of 42 cases. Scand J Gastroenterol 46:627–633PubMedCrossRef
32.
Zurück zum Zitat Miettinen M, Sarlomo-Rikala M, Sobin LH, Lasota J (2000) Esophageal stromal tumors: a clinicopathologic, immunohistochemical, and molecular genetic study of 17 cases and comparison with esophageal leiomyomas and leiomyosarcomas. Am J Surg Pathol 24:211–222PubMedCrossRef Miettinen M, Sarlomo-Rikala M, Sobin LH, Lasota J (2000) Esophageal stromal tumors: a clinicopathologic, immunohistochemical, and molecular genetic study of 17 cases and comparison with esophageal leiomyomas and leiomyosarcomas. Am J Surg Pathol 24:211–222PubMedCrossRef
33.
Zurück zum Zitat Zhu X, Zhang XQ, Li BM, Xu P, Zhang KH, Chen J (2007) Esophageal mesenchymal tumors: endoscopy, pathology and immunohistochemistry. World J Gastroenterol 13:768–773PubMed Zhu X, Zhang XQ, Li BM, Xu P, Zhang KH, Chen J (2007) Esophageal mesenchymal tumors: endoscopy, pathology and immunohistochemistry. World J Gastroenterol 13:768–773PubMed
34.
Zurück zum Zitat Kang YN, Jung HR, Hwang I (2010) Clinicopathological and immunohistochemical features of gastrointestinal stromal tumors. Cancer Res Treat 42:135–143PubMedCrossRef Kang YN, Jung HR, Hwang I (2010) Clinicopathological and immunohistochemical features of gastrointestinal stromal tumors. Cancer Res Treat 42:135–143PubMedCrossRef
35.
Zurück zum Zitat Stahl M, Kataja VV, Oliveira J (2005) ESMO minimal clinical recommendations for diagnosis, treatment and follow-up of esophageal cancer. Ann Oncol 16(Suppl 1):i26–i27PubMedCrossRef Stahl M, Kataja VV, Oliveira J (2005) ESMO minimal clinical recommendations for diagnosis, treatment and follow-up of esophageal cancer. Ann Oncol 16(Suppl 1):i26–i27PubMedCrossRef
36.
Zurück zum Zitat Stahl M, Oliveira J (2009) Esophageal cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol 20(Suppl 4):32–33PubMed Stahl M, Oliveira J (2009) Esophageal cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol 20(Suppl 4):32–33PubMed
Metadaten
Titel
Retrospective study of endoscopic submucosal tunnel dissection (ESTD) for surgical resection of esophageal leiomyoma
verfasst von
Lei Wang
Wei Ren
Zhimei Zhang
Jing Yu
Yihui Li
Yuankun Song
Publikationsdatum
01.11.2013
Verlag
Springer US
Erschienen in
Surgical Endoscopy / Ausgabe 11/2013
Print ISSN: 0930-2794
Elektronische ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-013-3035-z

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