Skip to main content
Erschienen in: Surgical Endoscopy 5/2019

10.09.2018 | 2018 SAGES Oral

Intraoperative air leak test reduces the rate of postoperative anastomotic leak: analysis of 777 laparoscopic left-sided colon resections

verfasst von: Marco Ettore Allaix, Adriana Lena, Maurizio Degiuli, Alberto Arezzo, Roberto Passera, Massimiliano Mistrangelo, Mario Morino

Erschienen in: Surgical Endoscopy | Ausgabe 5/2019

Einloggen, um Zugang zu erhalten

Abstract

Background

The evidence supporting the use of the air leak test (ALT) after laparoscopic left-sided colon resection (LLCR) to test the colorectal anastomosis (CA) integrity aiming at reducing the rate of postoperative CA leakage (CAL) is not conclusive. The aim of this study was to challenge the use of ALT after elective LLCR.

Methods

It is a retrospective analysis of a prospectively collected database including all patients undergoing elective LLCR with primary CA and no proximal bowel diversion between January 1996 and June 2017. The decision to perform the ALT was based on the individual surgeon routine practice. A multivariate analysis was performed to identify independent risk factors for CAL.

Results

A total of 777 LLCR without proximal diversion were included in the analysis: the CA was tested in 398 patients (ALT group), while intraoperative ALT was not performed in 379 patients (No-ALT group). The two groups were similar in demographic characteristics, indication, and type of procedure. Intraoperative ALT was positive in 20 (5%) patients: a stoma was created in 14 (70%) patients, while 6 (30%) patients had a suture repair alone. Overall, postoperative CAL occurred in 32 patients (4.1%): the postoperative CAL rate was lower in ALT patients (2.5% vs. 5.8%, p = 0.025). A reoperation was needed in 87.5% of cases. No CAL occurred in the 20 patients with intraoperative positive ALT. Multivariate analysis showed that ASA score 3–4 (OR 5.39, 95% CI 2.53–11.51, p < 0.001) and male sex (OR 3.96, 95% CI 1.66–9.43, p = 0.002) were independent risk factors for postoperative CAL, while intraoperative ALT independently reduced the postoperative CAL rate (OR 0.40, 95% CI 0.18–0.88, p = 0.022).

Conclusion

Intraoperative ALT allows to detect AL defects after LLCR that can be effectively managed intraoperatively, leading to a significant lower risk of postoperative CAL.
Literatur
1.
Zurück zum Zitat Midura EF, Hanseman D, Davis BR, Atkinson SJ, Abbott DE, Shah SA et al (2015) Risk factors and consequences of anastomotic leak after colectomy: a national analysis. Dis Colon Rectum 58:333–338CrossRefPubMed Midura EF, Hanseman D, Davis BR, Atkinson SJ, Abbott DE, Shah SA et al (2015) Risk factors and consequences of anastomotic leak after colectomy: a national analysis. Dis Colon Rectum 58:333–338CrossRefPubMed
2.
Zurück zum Zitat Hüttner FJ, Warschkow R, Schmied BM, Diener MK, Tarantino I, Ulrich A (2018) Prognostic impact of anastomotic leakage after elective colon resection for cancer—a propensity score matched analysis of 628 patients. Eur J Surg Oncol 44(4):456–462CrossRefPubMed Hüttner FJ, Warschkow R, Schmied BM, Diener MK, Tarantino I, Ulrich A (2018) Prognostic impact of anastomotic leakage after elective colon resection for cancer—a propensity score matched analysis of 628 patients. Eur J Surg Oncol 44(4):456–462CrossRefPubMed
3.
Zurück zum Zitat Frasson M, Flor-Lorente B, Rodríguez JL, Granero-Castro P, Hervás D, Alvarez Rico MA, Brao MJ, Sánchez González JM, Garcia-Granero E, ANACO Study Group (2015) Risk factors for anastomotic leak after colon resection for cancer: multivariate analysis and nomogram from a multicentric, prospective, national study with 3193 patients. Ann Surg 262(2):321–330CrossRefPubMed Frasson M, Flor-Lorente B, Rodríguez JL, Granero-Castro P, Hervás D, Alvarez Rico MA, Brao MJ, Sánchez González JM, Garcia-Granero E, ANACO Study Group (2015) Risk factors for anastomotic leak after colon resection for cancer: multivariate analysis and nomogram from a multicentric, prospective, national study with 3193 patients. Ann Surg 262(2):321–330CrossRefPubMed
4.
Zurück zum Zitat Rencuzogullari A, Benlice C, Valente M, Abbas MA, Remzi FH, Gorgun E (2017) Predictors of anastomotic leak in elderly patients after colectomy: nomogram-based assessment from the American College of Surgeons National Surgical Quality Program Procedure-Targeted Cohort. Dis Colon Rectum 60(5):527–536CrossRefPubMed Rencuzogullari A, Benlice C, Valente M, Abbas MA, Remzi FH, Gorgun E (2017) Predictors of anastomotic leak in elderly patients after colectomy: nomogram-based assessment from the American College of Surgeons National Surgical Quality Program Procedure-Targeted Cohort. Dis Colon Rectum 60(5):527–536CrossRefPubMed
5.
Zurück zum Zitat Dekker JW, Liefers GJ, de Mol van Otterloo JC, Putter H, Tollenaar RA (2011) Predicting the risk of anastomotic leakage in left-sided colorectal surgery using a colon leakage score. J Surg Res 166:e27–e34CrossRefPubMed Dekker JW, Liefers GJ, de Mol van Otterloo JC, Putter H, Tollenaar RA (2011) Predicting the risk of anastomotic leakage in left-sided colorectal surgery using a colon leakage score. J Surg Res 166:e27–e34CrossRefPubMed
6.
Zurück zum Zitat Rojas-Machado SA, Romero-Simó M, Arroyo A, Rojas-Machado A, López J, Calpena R (2016) Prediction of anastomotic leak in colorectal cancer surgery based on a new prognostic index PROCOLE (prognostic colorectal leakage) developed from the meta-analysis of observational studies of risk factors. Int J Colorectal Dis 31(2):197–210CrossRefPubMed Rojas-Machado SA, Romero-Simó M, Arroyo A, Rojas-Machado A, López J, Calpena R (2016) Prediction of anastomotic leak in colorectal cancer surgery based on a new prognostic index PROCOLE (prognostic colorectal leakage) developed from the meta-analysis of observational studies of risk factors. Int J Colorectal Dis 31(2):197–210CrossRefPubMed
7.
Zurück zum Zitat Karliczek A, Harlaar NJ, Zeebregts CJ, Wiggers T, Baas PC, van Dam GM (2009) Surgeons lack predictive accuracy for anastomotic leakage in gastrointestinal surgery. Int J Colorectal Dis 24(5):569–576CrossRefPubMed Karliczek A, Harlaar NJ, Zeebregts CJ, Wiggers T, Baas PC, van Dam GM (2009) Surgeons lack predictive accuracy for anastomotic leakage in gastrointestinal surgery. Int J Colorectal Dis 24(5):569–576CrossRefPubMed
8.
Zurück zum Zitat Monson JR, Weiser MR, Buie WD, Chang GJ, Rafferty JF, Buie WD, Rafferty J, Standards Practice Task Force of the American Society of Colon and Rectal Surgeons (2013) Practice parameters for the management of rectal cancer (revised). Dis Colon Rectum 56(5):535–550CrossRefPubMed Monson JR, Weiser MR, Buie WD, Chang GJ, Rafferty JF, Buie WD, Rafferty J, Standards Practice Task Force of the American Society of Colon and Rectal Surgeons (2013) Practice parameters for the management of rectal cancer (revised). Dis Colon Rectum 56(5):535–550CrossRefPubMed
9.
Zurück zum Zitat Nachiappan S, Askari A, Currie A, Kennedy RH, Feiz O (2014) Intraoperative assessment of colorectal anastomotic integrity: a systematic review. Surg Endosc 28:2513–2530CrossRefPubMed Nachiappan S, Askari A, Currie A, Kennedy RH, Feiz O (2014) Intraoperative assessment of colorectal anastomotic integrity: a systematic review. Surg Endosc 28:2513–2530CrossRefPubMed
10.
Zurück zum Zitat Li VK1, Wexner SD, Pulido N, Wang H, Jin HY, Weiss EG, Nogeuras JJ, Sands DR (2009) Use of routine intraoperative endoscopy in elective laparoscopic colorectal surgery: can it further avoid anastomotic failure? Surg Endosc 23(11):2459–2465CrossRefPubMed Li VK1, Wexner SD, Pulido N, Wang H, Jin HY, Weiss EG, Nogeuras JJ, Sands DR (2009) Use of routine intraoperative endoscopy in elective laparoscopic colorectal surgery: can it further avoid anastomotic failure? Surg Endosc 23(11):2459–2465CrossRefPubMed
11.
Zurück zum Zitat Kamal T, Pai A, Velchuru VR, Zawadzki M, Park JJ, Marecik SJ, Abcarian H, Prasad LM (2015) Should anastomotic assessment with flexible sigmoidoscopy be routine following laparoscopic restorative left colorectal resection? Colorectal Dis 17(2):160–164CrossRefPubMed Kamal T, Pai A, Velchuru VR, Zawadzki M, Park JJ, Marecik SJ, Abcarian H, Prasad LM (2015) Should anastomotic assessment with flexible sigmoidoscopy be routine following laparoscopic restorative left colorectal resection? Colorectal Dis 17(2):160–164CrossRefPubMed
12.
Zurück zum Zitat Blanco-Colino R, Espin-Basany E (2018) Intraoperative use of ICG fluorescence imaging to reduce the risk of anastomotic leakage in colorectal surgery: a systematic review and meta-analysis. Tech Coloproctol 22(1):15–23CrossRefPubMed Blanco-Colino R, Espin-Basany E (2018) Intraoperative use of ICG fluorescence imaging to reduce the risk of anastomotic leakage in colorectal surgery: a systematic review and meta-analysis. Tech Coloproctol 22(1):15–23CrossRefPubMed
13.
Zurück zum Zitat Wu Z, van de Haar RC, Sparreboom CL, Boersema GS, Li Z, Ji J, Jeekel J, Lange JF (2016) Is the intraoperative air leak test effective in the prevention of colorectal anastomotic leakage? A systematic review and meta-analysis. Int J Colorectal Dis 31(8):1409–1417CrossRefPubMedPubMedCentral Wu Z, van de Haar RC, Sparreboom CL, Boersema GS, Li Z, Ji J, Jeekel J, Lange JF (2016) Is the intraoperative air leak test effective in the prevention of colorectal anastomotic leakage? A systematic review and meta-analysis. Int J Colorectal Dis 31(8):1409–1417CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Slim K, Vicaut E, Panis Y, Chipponi J (2004) Meta-analysis of randomized clinical trials of colorectal surgery with or without mechanical bowel preparation. Br J Surg 91:1125–1130CrossRefPubMed Slim K, Vicaut E, Panis Y, Chipponi J (2004) Meta-analysis of randomized clinical trials of colorectal surgery with or without mechanical bowel preparation. Br J Surg 91:1125–1130CrossRefPubMed
15.
Zurück zum Zitat Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373–383CrossRefPubMed Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373–383CrossRefPubMed
16.
Zurück zum Zitat Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications. A new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205–213CrossRefPubMedPubMedCentral Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications. A new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205–213CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Nesbakken A, Nygaard K, Lunde OC (2001) Outcome and late functional results after anastomotic leakage following mesorectal excision for rectal cancer. Br J Surg 88(3):400–404CrossRefPubMed Nesbakken A, Nygaard K, Lunde OC (2001) Outcome and late functional results after anastomotic leakage following mesorectal excision for rectal cancer. Br J Surg 88(3):400–404CrossRefPubMed
18.
Zurück zum Zitat Buchs NC, Gervaz P, Secic M, Bucher P, Mugnier-Konrad B, Morel P (2008) Incidence, consequences, and risk factors for anastomotic dehiscence after colorectal surgery: a prospective monocentric study. Int J Colorectal Dis 23(3):265–270CrossRefPubMed Buchs NC, Gervaz P, Secic M, Bucher P, Mugnier-Konrad B, Morel P (2008) Incidence, consequences, and risk factors for anastomotic dehiscence after colorectal surgery: a prospective monocentric study. Int J Colorectal Dis 23(3):265–270CrossRefPubMed
19.
Zurück zum Zitat McArdle CS, McMillan DC, Hole DJ (2005) Impact of anastomotic leakage on long-term survival of patients undergoing curative resection for colorectal cancer. Br J Surg 92(9):1150–1154CrossRefPubMed McArdle CS, McMillan DC, Hole DJ (2005) Impact of anastomotic leakage on long-term survival of patients undergoing curative resection for colorectal cancer. Br J Surg 92(9):1150–1154CrossRefPubMed
20.
Zurück zum Zitat Shogan BD, Carlisle EM, Alverdy JC, Umanskiy K (2013) Do we really know why colorectal anastomoses leak? J Gastrointest Surg 17:1698–1707CrossRefPubMed Shogan BD, Carlisle EM, Alverdy JC, Umanskiy K (2013) Do we really know why colorectal anastomoses leak? J Gastrointest Surg 17:1698–1707CrossRefPubMed
21.
Zurück zum Zitat Seike K, Koda K, Saito N, Oda K, Kosugi C, Shimizu K, Miyazaki M (2007) Laser Doppler assessment of the influence of division at the root of the inferior mesenteric artery on anastomotic blood flow in rectosigmoid cancer surgery. Int J Colorectal Dis 22:689–697CrossRefPubMed Seike K, Koda K, Saito N, Oda K, Kosugi C, Shimizu K, Miyazaki M (2007) Laser Doppler assessment of the influence of division at the root of the inferior mesenteric artery on anastomotic blood flow in rectosigmoid cancer surgery. Int J Colorectal Dis 22:689–697CrossRefPubMed
22.
Zurück zum Zitat Boyle NH, Manifold D, Jordan MH, Mason RC (2000) Intraoperative assessment of colonic perfusion using scanning laser Doppler flowmetry during colonic resection. J Am Coll Surg 191:504–510CrossRefPubMed Boyle NH, Manifold D, Jordan MH, Mason RC (2000) Intraoperative assessment of colonic perfusion using scanning laser Doppler flowmetry during colonic resection. J Am Coll Surg 191:504–510CrossRefPubMed
23.
Zurück zum Zitat Sheridan WG, Lowndes RH, Young HL (1987) Tissue oxygen tension as a predictor of colonic anastomotic healing. Dis Colon Rectum 30:867–871CrossRefPubMed Sheridan WG, Lowndes RH, Young HL (1987) Tissue oxygen tension as a predictor of colonic anastomotic healing. Dis Colon Rectum 30:867–871CrossRefPubMed
24.
Zurück zum Zitat Beard JD, Nicholson ML, Sayers RD, Lloyd D, Everson NW (1990) Intraoperative air testing of colorectal anastomoses: a prospective, randomized trial. Br J Surg 77:1095–1097CrossRefPubMed Beard JD, Nicholson ML, Sayers RD, Lloyd D, Everson NW (1990) Intraoperative air testing of colorectal anastomoses: a prospective, randomized trial. Br J Surg 77:1095–1097CrossRefPubMed
25.
Zurück zum Zitat Ivanov D, Cvijanovic R, Gvozdenovic L (2011) Intraoperative air testing of colorectal anastomoses. Srp Arh Celok Lek 139:333–338CrossRefPubMed Ivanov D, Cvijanovic R, Gvozdenovic L (2011) Intraoperative air testing of colorectal anastomoses. Srp Arh Celok Lek 139:333–338CrossRefPubMed
26.
Zurück zum Zitat Ricciardi R, Roberts PL, Marcello PW, Hall JF, Read TE, Schoetz DJ (2009) Anastomotic leak testing after colorectal resection: what are the data? Arch Surg 144:407–411CrossRefPubMed Ricciardi R, Roberts PL, Marcello PW, Hall JF, Read TE, Schoetz DJ (2009) Anastomotic leak testing after colorectal resection: what are the data? Arch Surg 144:407–411CrossRefPubMed
27.
Zurück zum Zitat Davies AH, Bartolo DC, Richards AE, Johnson CD, McC Mortensen NJ (1988) Intra-operative air testing: an audit on rectal anastomosis. Ann R Coll Surg Engl 70:345–347PubMedPubMedCentral Davies AH, Bartolo DC, Richards AE, Johnson CD, McC Mortensen NJ (1988) Intra-operative air testing: an audit on rectal anastomosis. Ann R Coll Surg Engl 70:345–347PubMedPubMedCentral
28.
Zurück zum Zitat Lazorthes F, Chiotassol P (1986) Stapled colorectal anastomoses: peroperative integrity of the anastomosis and risk of postoperative leakage. Int J Colorectal Dis 1:96–98CrossRefPubMed Lazorthes F, Chiotassol P (1986) Stapled colorectal anastomoses: peroperative integrity of the anastomosis and risk of postoperative leakage. Int J Colorectal Dis 1:96–98CrossRefPubMed
29.
Zurück zum Zitat Griffith CD, Hardcastle JD (1990) Intraoperative testing of anastomotic integrity after stapled anterior resection for cancer. J R Coll Surg Edinb 35:106–108PubMed Griffith CD, Hardcastle JD (1990) Intraoperative testing of anastomotic integrity after stapled anterior resection for cancer. J R Coll Surg Edinb 35:106–108PubMed
30.
Zurück zum Zitat Yalin R, Aktan AO, Yeğen C, Döşlüoğlu H, Okboy N (1993) Importance of testing stapled rectal anastomoses with air. Eur J Surg 159:49–51PubMed Yalin R, Aktan AO, Yeğen C, Döşlüoğlu H, Okboy N (1993) Importance of testing stapled rectal anastomoses with air. Eur J Surg 159:49–51PubMed
31.
Zurück zum Zitat Pritchard GA, Krouma FF, Stamatakis JD (1990) Intraoperative testing of colorectal anastomosis can be misleading. Br J Surg 77:1105CrossRefPubMed Pritchard GA, Krouma FF, Stamatakis JD (1990) Intraoperative testing of colorectal anastomosis can be misleading. Br J Surg 77:1105CrossRefPubMed
32.
Zurück zum Zitat Daams F, Wu Z, Lahaye MJ, Jeekel J, Lange JF (2014) Prediction and diagnosis of colorectal anastomotic leakage: a systematic review of literature. World J Gastrointest Surg 6:14–26CrossRefPubMedPubMedCentral Daams F, Wu Z, Lahaye MJ, Jeekel J, Lange JF (2014) Prediction and diagnosis of colorectal anastomotic leakage: a systematic review of literature. World J Gastrointest Surg 6:14–26CrossRefPubMedPubMedCentral
33.
Zurück zum Zitat Mitchem JB, Stafford C, Francone TD, Roberts PL, Schoetz DJ, Marcello PW, Ricciardi R (2017) What is the optimal management of an intra-operative air leak in a colorectal anastomosis? Colorectal Dis 20:O39–O45CrossRef Mitchem JB, Stafford C, Francone TD, Roberts PL, Schoetz DJ, Marcello PW, Ricciardi R (2017) What is the optimal management of an intra-operative air leak in a colorectal anastomosis? Colorectal Dis 20:O39–O45CrossRef
34.
Zurück zum Zitat Nastro P, Knowles CH, McGrath A, Heyman B, Porrett TR, Lunniss PJ (2010) Complications of intestinal stomas. Br J Surg 97(12):1885–1889CrossRefPubMed Nastro P, Knowles CH, McGrath A, Heyman B, Porrett TR, Lunniss PJ (2010) Complications of intestinal stomas. Br J Surg 97(12):1885–1889CrossRefPubMed
35.
Zurück zum Zitat Zhang HY, Zhao CL, Xie J, Ye YW, Sun JF, Ding ZH, Xu HN, Ding L (2016) To drain or not to drain in colorectal anastomosis: a meta-analysis. Int J Colorectal Dis 31(5):951–960CrossRefPubMedPubMedCentral Zhang HY, Zhao CL, Xie J, Ye YW, Sun JF, Ding ZH, Xu HN, Ding L (2016) To drain or not to drain in colorectal anastomosis: a meta-analysis. Int J Colorectal Dis 31(5):951–960CrossRefPubMedPubMedCentral
36.
Zurück zum Zitat Fukunaga Y, Higashino M, Tanimura S, Takemura M, Osugi H (2008) Laparoscopic colorectal surgery for neoplasm. A large series by a single surgeon. Surg Endosc 22(6):1452–1458CrossRefPubMed Fukunaga Y, Higashino M, Tanimura S, Takemura M, Osugi H (2008) Laparoscopic colorectal surgery for neoplasm. A large series by a single surgeon. Surg Endosc 22(6):1452–1458CrossRefPubMed
Metadaten
Titel
Intraoperative air leak test reduces the rate of postoperative anastomotic leak: analysis of 777 laparoscopic left-sided colon resections
verfasst von
Marco Ettore Allaix
Adriana Lena
Maurizio Degiuli
Alberto Arezzo
Roberto Passera
Massimiliano Mistrangelo
Mario Morino
Publikationsdatum
10.09.2018
Verlag
Springer US
Erschienen in
Surgical Endoscopy / Ausgabe 5/2019
Print ISSN: 0930-2794
Elektronische ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-018-6421-8

Weitere Artikel der Ausgabe 5/2019

Surgical Endoscopy 5/2019 Zur Ausgabe

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.