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Erschienen in: Pediatric Nephrology 10/2003

01.10.2003 | Original Article

Carotid ultrasonography for detection of vascular abnormalities in hypertensive children

verfasst von: Jonathan M. Sorof, Andrei V. Alexandrov, Zsolt Garami, Jennifer L. Turner, Robert E. Grafe, Dejian Lai, Ronald J. Portman

Erschienen in: Pediatric Nephrology | Ausgabe 10/2003

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Abstract.

To determine whether hypertension and overweight status are associated with increased carotid intimal-medial thickness (cIMT) in children, vascular ultrasonography was performed in newly diagnosed hypertensive patients (n=53) and normotensive controls (n=33). Hypertensive subjects were identified either by referral or by systematic school-based hypertension screening. Hypertension was defined as blood pressure above the 95th percentile based on current Task Force criteria, and overweight was defined as body mass index (BMI) >25 kg/m2. cIMT was assessed by high-resolution vascular ultrasonography of the distal common carotid artery. Hypertensive subjects had a higher cIMT than normotensive subjects (0.62 vs. 0.53 mm, P<0.00001). This difference remained significant after controlling for the effects of gender, race, age, height, weight, and BMI. Similarly, overweight subjects had a higher cIMT than normal-weight subjects (0.63 vs. 0.54 mm, P<0.0001). Subjects with both systolic and diastolic hypertension had higher cIMT than those with isolated systolic hypertension (0.67 vs. 0.60, P<0.05). cIMT showed significant positive pairwise correlation with age, height, weight, BMI, and systolic blood pressure. Among all clinical variables analyzed, cIMT was most strongly correlated with BMI (r=0.53, P<0.001). These results provide further evidence that vasculopathy occurs in association with known cardiovascular risk factors such as hypertension and obesity during childhood.
Literatur
1.
Zurück zum Zitat Johnson MC, Bergersen LJ, Beck A, Dick G, Cole BR (1999) Diastolic function and tachycardia in hypertensive children. Am J Hypertens 12:1009–1014CrossRefPubMed Johnson MC, Bergersen LJ, Beck A, Dick G, Cole BR (1999) Diastolic function and tachycardia in hypertensive children. Am J Hypertens 12:1009–1014CrossRefPubMed
2.
Zurück zum Zitat Daniels SR, Loggie JM, Khoury P, Kimball TR (1998) Left ventricular geometry and severe left ventricular hypertrophy in children and adolescents with essential hypertension. Circulation 97:1907–1911PubMed Daniels SR, Loggie JM, Khoury P, Kimball TR (1998) Left ventricular geometry and severe left ventricular hypertrophy in children and adolescents with essential hypertension. Circulation 97:1907–1911PubMed
3.
Zurück zum Zitat Laird WP, Fixler DE (1981) Left ventricular hypertrophy in adolescents with elevated blood pressure: assessment by chest roentgenography, electrocardiography, and echocardiography. Pediatrics 67:255–259PubMed Laird WP, Fixler DE (1981) Left ventricular hypertrophy in adolescents with elevated blood pressure: assessment by chest roentgenography, electrocardiography, and echocardiography. Pediatrics 67:255–259PubMed
4.
Zurück zum Zitat Goldring D, Hernandez A, Choi S, Lee JY, Londe S, Lindgren FT, Burton RM (1979) Blood pressure in a high school population. II. Clinical profile of the juvenile hypertensive. J Pediatr 95:298–304PubMed Goldring D, Hernandez A, Choi S, Lee JY, Londe S, Lindgren FT, Burton RM (1979) Blood pressure in a high school population. II. Clinical profile of the juvenile hypertensive. J Pediatr 95:298–304PubMed
5.
Zurück zum Zitat Culpepper WS (1983) Cardiac anatomy and function in juvenile hypertension. Current understanding and future concerns. Am J Med 75:57–61 Culpepper WS (1983) Cardiac anatomy and function in juvenile hypertension. Current understanding and future concerns. Am J Med 75:57–61
6.
Zurück zum Zitat Culpepper WS, Sodt PC, Messerli FH, Ruschhaupt DG, Arcilla RA (1983) Cardiac status in juvenile borderline hypertension. Ann Intern Med 98:1–7PubMed Culpepper WS, Sodt PC, Messerli FH, Ruschhaupt DG, Arcilla RA (1983) Cardiac status in juvenile borderline hypertension. Ann Intern Med 98:1–7PubMed
7.
Zurück zum Zitat Schieken RM, Clarke WR, Lauer RM (1981) Left ventricular hypertrophy in children with blood pressures in the upper quintile of the distribution. The Muscatine Study. Hypertension 3:669–675PubMed Schieken RM, Clarke WR, Lauer RM (1981) Left ventricular hypertrophy in children with blood pressures in the upper quintile of the distribution. The Muscatine Study. Hypertension 3:669–675PubMed
8.
Zurück zum Zitat Daniels SR, Meyer RA, Loggie JM (1990) Determinants of cardiac involvement in children and adolescents with essential hypertension. Circulation 82:1243–1248PubMed Daniels SR, Meyer RA, Loggie JM (1990) Determinants of cardiac involvement in children and adolescents with essential hypertension. Circulation 82:1243–1248PubMed
9.
Zurück zum Zitat Belsha CW, Wells TG, McNiece KL, Seib PM, Plummer JK, Berry PL (1998) Influence of diurnal blood pressure variations on target organ abnormalities in adolescents with mild essential hypertension. Am J Hypertens 11:410–417PubMed Belsha CW, Wells TG, McNiece KL, Seib PM, Plummer JK, Berry PL (1998) Influence of diurnal blood pressure variations on target organ abnormalities in adolescents with mild essential hypertension. Am J Hypertens 11:410–417PubMed
10.
Zurück zum Zitat Heiss G, Sharrett AR, Barnes R, Chambless LE, Szklo M, Alzola C (1991) Carotid atherosclerosis measured by B-mode ultrasound in populations: associations with cardiovascular risk factors in the ARIC study. Am J Epidemiol 134:250–256PubMed Heiss G, Sharrett AR, Barnes R, Chambless LE, Szklo M, Alzola C (1991) Carotid atherosclerosis measured by B-mode ultrasound in populations: associations with cardiovascular risk factors in the ARIC study. Am J Epidemiol 134:250–256PubMed
11.
Zurück zum Zitat O'Leary DH, Polak JF, Kronmal RA, Kittner SJ, Bond MG, Wolfson SKJ, Bommer W, Price TR, Gardin JM, Savage PJ (1992) Distribution and correlates of sonographically detected carotid artery disease in the Cardiovascular Health Study. The CHS Collaborative Research Group. Stroke 23:1752–1760PubMed O'Leary DH, Polak JF, Kronmal RA, Kittner SJ, Bond MG, Wolfson SKJ, Bommer W, Price TR, Gardin JM, Savage PJ (1992) Distribution and correlates of sonographically detected carotid artery disease in the Cardiovascular Health Study. The CHS Collaborative Research Group. Stroke 23:1752–1760PubMed
12.
Zurück zum Zitat Salonen JT, Salonen R (1993) Ultrasound B-mode imaging in observational studies of atherosclerotic progression. Circulation 87:1156–1165 Salonen JT, Salonen R (1993) Ultrasound B-mode imaging in observational studies of atherosclerotic progression. Circulation 87:1156–1165
13.
Zurück zum Zitat Sorof JM, Alexandrov AV, Cardwell G, Portman RJ (2003) Carotid artery intimal-medial thickness and left ventricular hypertrophy in children with elevated blood pressure. Pediatrics 111:61–66PubMed Sorof JM, Alexandrov AV, Cardwell G, Portman RJ (2003) Carotid artery intimal-medial thickness and left ventricular hypertrophy in children with elevated blood pressure. Pediatrics 111:61–66PubMed
14.
Zurück zum Zitat Jarvisalo MJ, Jartti L, Nanto-Salonen K, Irjala K, Ronnemaa T, Hartiala JJ, Celermajer DS, Raitakari OT (2001) Increased aortic intima-media thickness: a marker of preclinical atherosclerosis in high-risk children. Circulation 104:2943–2947PubMed Jarvisalo MJ, Jartti L, Nanto-Salonen K, Irjala K, Ronnemaa T, Hartiala JJ, Celermajer DS, Raitakari OT (2001) Increased aortic intima-media thickness: a marker of preclinical atherosclerosis in high-risk children. Circulation 104:2943–2947PubMed
15.
Zurück zum Zitat Peppa-Patrikiou M, Scordili M, Antoniou A, Giannaki M, Dracopoulou M, Dacou-Voutetakis C (1998) Carotid atherosclerosis in adolescents and young adults with IDDM. Relation to urinary endothelin, albumin, free cortisol, and other factors. Diabetes Care 21:1004–1007PubMed Peppa-Patrikiou M, Scordili M, Antoniou A, Giannaki M, Dracopoulou M, Dacou-Voutetakis C (1998) Carotid atherosclerosis in adolescents and young adults with IDDM. Relation to urinary endothelin, albumin, free cortisol, and other factors. Diabetes Care 21:1004–1007PubMed
16.
Zurück zum Zitat Jarvisalo MJ, Putto-Laurila A, Jartti L, Lehtimaki T, Solakivi T, Ronnemaa T, Raitakari OT (2002) Carotid artery intima-media thickness in children with type 1 diabetes. Diabetes 51:493–498PubMed Jarvisalo MJ, Putto-Laurila A, Jartti L, Lehtimaki T, Solakivi T, Ronnemaa T, Raitakari OT (2002) Carotid artery intima-media thickness in children with type 1 diabetes. Diabetes 51:493–498PubMed
17.
Zurück zum Zitat Virkola K, Pesonen E, Akerblom HK, Siimes MA (1997) Cholesterol and carotid artery wall in children and adolescents with familial hypercholesterolaemia: a controlled study by ultrasound. Acta Paediatr 86:1203–1207PubMed Virkola K, Pesonen E, Akerblom HK, Siimes MA (1997) Cholesterol and carotid artery wall in children and adolescents with familial hypercholesterolaemia: a controlled study by ultrasound. Acta Paediatr 86:1203–1207PubMed
18.
Zurück zum Zitat Sorof JM, Poffenbarger T, Franco K, Bernard L, Portman RJ (2002) Isolated systolic hypertension, obesity, and hyperkinetic hemodynamic states in children. J Pediatr 140:660–666CrossRefPubMed Sorof JM, Poffenbarger T, Franco K, Bernard L, Portman RJ (2002) Isolated systolic hypertension, obesity, and hyperkinetic hemodynamic states in children. J Pediatr 140:660–666CrossRefPubMed
19.
Zurück zum Zitat Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents: a working group report from the National High Blood Pressure Education Program. National High Blood Pressure Education Program Working Group on Hypertension Control in Children and Adolescents (1996) Pediatrics 98:649–658 Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents: a working group report from the National High Blood Pressure Education Program. National High Blood Pressure Education Program Working Group on Hypertension Control in Children and Adolescents (1996) Pediatrics 98:649–658
20.
Zurück zum Zitat American Society of Hypertension (1992) Recommendations for routine blood pressure measurement by indirect cuff sphygmomanometry. Am J Hypertens 5:207–209PubMed American Society of Hypertension (1992) Recommendations for routine blood pressure measurement by indirect cuff sphygmomanometry. Am J Hypertens 5:207–209PubMed
21.
Zurück zum Zitat Oalmann MC, Strong JP, Tracy RE, Malcom GT (1997) Atherosclerosis in youth: are hypertension and other coronary heart disease risk factors already at work? Pediatr Nephrol 11:99–107 Oalmann MC, Strong JP, Tracy RE, Malcom GT (1997) Atherosclerosis in youth: are hypertension and other coronary heart disease risk factors already at work? Pediatr Nephrol 11:99–107
22.
Zurück zum Zitat Enos WF, Holmes RH, Beyer J (1953) Coronary disease among United States soldiers killed in action in Korea. Preliminary report. JAMA 152:1090–1093 Enos WF, Holmes RH, Beyer J (1953) Coronary disease among United States soldiers killed in action in Korea. Preliminary report. JAMA 152:1090–1093
23.
Zurück zum Zitat McNamara JJ, Molot MA, Stremple JF, Cutting RT (1971) Coronary artery disease in combat casualties in Vietnam. JAMA 216:1185–1187CrossRefPubMed McNamara JJ, Molot MA, Stremple JF, Cutting RT (1971) Coronary artery disease in combat casualties in Vietnam. JAMA 216:1185–1187CrossRefPubMed
24.
Zurück zum Zitat Strong JP, Malcom GT, Oalmann MC (1995) Environmental and genetic risk factors in early human atherogenesis: lessons from the PDAY study. Pathol Int 45:403–408PubMed Strong JP, Malcom GT, Oalmann MC (1995) Environmental and genetic risk factors in early human atherogenesis: lessons from the PDAY study. Pathol Int 45:403–408PubMed
25.
Zurück zum Zitat Berenson GS, Srinivasan SR, Bao W, Newman WP, Tracy RE, Wattigney WA (1998) Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med 338:1650–1656PubMed Berenson GS, Srinivasan SR, Bao W, Newman WP, Tracy RE, Wattigney WA (1998) Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med 338:1650–1656PubMed
26.
Zurück zum Zitat Tonstad S, Joakimsen O, Stensland-Bugge E, Leren TP, Ose L, Russell D, Bonaa KH (1996) Risk factors related to carotid intima-media thickness and plaque in children with familial hypercholesterolemia and control subjects. Arterioscler Thromb Vasc Biol 16:984–991PubMed Tonstad S, Joakimsen O, Stensland-Bugge E, Leren TP, Ose L, Russell D, Bonaa KH (1996) Risk factors related to carotid intima-media thickness and plaque in children with familial hypercholesterolemia and control subjects. Arterioscler Thromb Vasc Biol 16:984–991PubMed
27.
Zurück zum Zitat Sorof JM, Poffenbarger T, Franco K, Portman R (2001) Evaluation of white coat hypertension in children: importance of the definitions of normal ambulatory blood pressure and the severity of casual hypertension. Am J Hypertens 14:855–860CrossRefPubMed Sorof JM, Poffenbarger T, Franco K, Portman R (2001) Evaluation of white coat hypertension in children: importance of the definitions of normal ambulatory blood pressure and the severity of casual hypertension. Am J Hypertens 14:855–860CrossRefPubMed
28.
Zurück zum Zitat Sass C, Herbeth B, Chapet O, Siest G, Visvikis S, Zannad F (1998) Intima-media thickness and diameter of carotid and femoral arteries in children, adolescents and adults from the Stanislas cohort: effect of age, sex, anthropometry and blood pressure. J Hypertens 16:1593–1602CrossRefPubMed Sass C, Herbeth B, Chapet O, Siest G, Visvikis S, Zannad F (1998) Intima-media thickness and diameter of carotid and femoral arteries in children, adolescents and adults from the Stanislas cohort: effect of age, sex, anthropometry and blood pressure. J Hypertens 16:1593–1602CrossRefPubMed
29.
Zurück zum Zitat Sorof J, Daniels S (2002) Obesity hypertension in children: a problem of epidemic proportions. Hypertension 40:441–447CrossRefPubMed Sorof J, Daniels S (2002) Obesity hypertension in children: a problem of epidemic proportions. Hypertension 40:441–447CrossRefPubMed
Metadaten
Titel
Carotid ultrasonography for detection of vascular abnormalities in hypertensive children
verfasst von
Jonathan M. Sorof
Andrei V. Alexandrov
Zsolt Garami
Jennifer L. Turner
Robert E. Grafe
Dejian Lai
Ronald J. Portman
Publikationsdatum
01.10.2003
Verlag
Springer-Verlag
Erschienen in
Pediatric Nephrology / Ausgabe 10/2003
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-003-1187-0

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