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Pediatric Nephrology

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01.11.2007 | Original Article

Retinoic acid enhances nephron endowment in rats exposed to maternal protein restriction

verfasst von: John Makrakis, Monika A. Zimanyi, M. Jane Black

Erschienen in: Pediatric Nephrology | Ausgabe 11/2007

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Abstract

A reduced nephron complement at birth renders the kidney susceptible to renal disease in adulthood. Retinoic acid (RA; the active metabolite of vitamin A) is linked to nephrogenesis in vitro and in vivo. The aim of this study was to determine the effect of administration of retinoic acid in midgestation in rats on nephron endowment in offspring exposed to maternal protein restriction. Rats were fed either a normal-protein diet (NPD) or a low-protein diet (LPD) during pregnancy and lactation. Half of the dams in the LPD group were injected intraperitoneally with retinoic acid (20 mg/kg) during gestation at embryonic day 11.5. At 4 weeks of age, the offspring were anesthetized and perfusion-fixed, and nephron number estimated using unbiased stereological techniques. Body weight and kidney volume was significantly reduced in all LPD offspring. There was a significant 29% reduction in nephron number in the LPD group compared with the NPD offspring, whereas the number of nephrons in kidneys from the LPD + RA offspring was not significantly different compared with controls. In conclusion, administration of a single bolus dose of retinoic acid during midgestation restored nephron endowment to normal in offspring exposed to maternal protein restriction.

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Titel: Retinoic acid enhances nephron endowment in rats exposed to maternal protein restriction
verfasst von: John Makrakis
Monika A. Zimanyi
M. Jane Black
Publikationsdatum: 01.11.2007
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 11/2007
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-007-0572-5

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Retinoic acid enhances nephron endowment in rats exposed to maternal protein restriction

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