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01.12.2007 | Original Article

Serum levels of galactose-deficient IgA in children with IgA nephropathy and Henoch-Schönlein purpura

verfasst von: Keith K. Lau, Robert J. Wyatt, Zina Moldoveanu, Milan Tomana, Bruce A. Julian, Ronald J. Hogg, Jeannette Y. Lee, Wen-Qiang Huang, Jiri Mestecky, Jan Novak

Erschienen in: Pediatric Nephrology | Ausgabe 12/2007

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Abstract

IgA nephropathy and Henoch-Schönlein purpura nephritis (HSPN) are related diseases characterized by deposits of IgA1-containing immune complexes in the renal mesangium. Adult patients with IgA nephropathy have aberrantly glycosylated IgA1 (galactose-deficient O-linked glycans) in the circulation and renal deposits. However, IgA1 glycosylation has not been studied in pediatric patients with IgA nephropathy. Using our quantitative lectin enzyme-linked immunosorbent assay (ELISA) test, we measured serum levels of galactose-deficient IgA1 of children with IgA nephropathy and HSPN and controls. Children with IgA nephropathy and HSPN had serum levels higher than those of healthy children or renal-disease controls with C1q nephropathy. Furthermore, lectin ELISA identified patients with HSPN whose clinical course mimicked that of IgA nephropathy. In summary, pediatric patients with IgA nephropathy and HSPN have an aberrancy in the glycosylation in IgA1 O-linked glycans that is similar to that in adults with IgA nephropathy.

D’Amico G (1987) The commonest glomerulonephritis in the world: IgA nephropathy. Q J Med 64:709–727PubMed

Delos Santos NM, Wyatt RJ (2004) Pediatric IgA nephropathies: Clinical aspects and therapeutic approaches. Semin Nephrol 24:269–286CrossRef

Saulsbury FT (2001) Henoch-Schönlein purpura. Curr Opin Rheumatol 13:35–40CrossRef

Levy M, Broyer M, Arsan A, Levy-Bentolila D, Habib R (1976) Anaphylactoid purpura nephritis in childhood: Natural history and immunopathology. Adv Nephrol 6:183–228

Evans DJ, Gwynn-Williams D, Peters DK, Sissons JG, Boulton-Jones JM, Ogg CS, Cameron JS, Hoffbrand BI (1973) Glomerular deposition of properdin in Henoch-Schönlein purpura syndrome and idiopathic focal glomerulonephritis. Br Med J 11:326–328CrossRef

Meadow SR, Scott DG (1985) Berger disease: Henoch-Schönlein syndrome without the rash. J Pediatr 106:27–32CrossRef

Levy M (1989) Familial cases of Berger’s disease and anaphylactoid purpura: more frequent than previously thought. Am J Med 87:246–248CrossRef

Nakamoto Y, Asano Y, Dohi K, Fujioka M, Iida H, Kida H, Kibe Y, Hattori N, Takeuchi J (1978) Primary IgA glomerulonephritis and Schonlein-Henoch purpura nephritis: clinicopathological and immunohistological characteristics. Q J Med 47:495–516PubMed

Waldo FB (1988) Is Henoch-Schönlein purpura the systemic form of IgA nephropathy? Am J Kidney Dis 12:373–377CrossRef

10.

Andre PM, Le Pogamp P, Chevet D (1990) Impairment of jacalin binding to serum IgA in IgA nephropathy. J Clin Lab Anal 4:115–119CrossRef

11.

Mestecky J, Tomana M, Crowley-Nowick PA, Moldoveanu Z, Julian BA, Jackson S (1993) Defective galactosylation and clearance of IgA1 molecules as a possible etiopathogenic factor in IgA nephropathy. Contrib Nephrol 104:172–182CrossRef

12.

Allen AC, Harper SJ, Feehally J (1995) Galactosylation of N- and O-linked carbohydrate moieties of IgA1 and IgG in IgA nephropathy. Clin Exp Immunol 100:470–474CrossRef

13.

Tomana M, Matousovic K, Julian BA, Radl J, Konecny K, Mestecky J (1997) Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG. Kidney Int 52:509–516CrossRef

14.

Allen AC, Willis FR, Beattie TJ, Feehally J (1998) Abnormal IgA glycosylation in Henoch-Schönlein purpura restricted to patients with clinical nephritis. Nephrol Dial Transplant 13:930–934CrossRef

15.

Coppo R, Basolo B, Martina G, Rollino C, De Marchi M, Giacchino F, Mazzucco G, Messina M, Piccoli G (1982) Circulating immune complexes containing IgA, IgG and IgM in patients with primary IgA nephropathy and with Henoch-Schönlein nephritis. Correlation with clinical and histologic signs of activity. Clin Nephrol 18:230–239PubMed

16.

Amore A, Cirina P, Conti G, Brusa P, Peruzzi L, Coppo R (2001) Glycosylation of circulating IgA in patients with IgA nephropathy modulates proliferation and apoptosis of mesangial cells. J Am Soc Nephrol 12:1862–1871PubMed

17.

Coppo R, Amore A (2004) Aberrant glycosylation in IgA nephropathy (IgAN). Kidney Int 65:1544–1547CrossRef

18.

Novak J, Tomana M, Matousovic K, Brown R, Hall S, Novak L, Julian BA, Wyatt RJ, Mestecky J (2005) IgA1-containing immune complexes in IgA nephropathy differentially affect proliferation of mesangial cells. Kidney Int 67:504–513CrossRef

19.

Hogg R, Tomana M, Gray J, Mestecky J (1997) Deficient IgA1 galactosylation in children with idiopatic IgA nephropathy (IgAN) and Henoch-Schönlein nephritis (HSPN). J Am Soc Nephrol 8:88A

20.

Moore JS, Kulhavy R, Tomana M, Moldoveanu Z, Suzuki H, Brown R, Hall S, Kilian M, Poulsen K, Mestecky J, Julian BA, Novak J (2007) Reactivities of N-acetylgalactosamine-specific lectins with human IgA1 proteins. Mol Immunol 44:2598–2604CrossRef

21.

Moldoveanu Z, Wyatt RJ, Lee J, Tomana M, Julian BA, Mestecky J, Huang W-Q, Anreddy SR, Hastings MC, Lau KK, Cook WJ, Novak J (2007) Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels. Kidney Int 71:134–138CrossRef

22.

Schwartz GJ, Haycock GB, Edelman CM Jr, Spitzer A (1976) A simple estimate of glomerular filtration rate in children derived from body length and serum creatinine. Pediatrics 58:522–526

23.

Tomana M, Novak J, Julian BA, Matousovic K, Konecny K, Mestecky J (1999) Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies. J Clin Invest 104:73–81CrossRef

24.

Yoshikawa N, Ito H, Nakamura H (1992) Prognostic indicators in childhood IgA nephropathy. Nephron 60:60–67CrossRef

25.

Ariceta G, Gallego N, Lopez-Fernandez Y, Vallo A, Quintella MJ, Rodriquez Soriano J (2001) Long-term prognosis of childhood IgA nephropathy in adult life. Med Clin 116:361–364CrossRef

26.

Delos Santos NM, Ault BH, Gharavi AG, Kritchevsky SB, Quasney MW, Jackson EC, Fisher KA, Woodford SY, Mitchell BL, Gaber LW, Arheart KL, Wyatt RJ (2002) Angiotensin-converting enzyme genotype and outcome in pediatric IgA nephropathy. Pediatr Nephrol 17:496–502CrossRef

27.

Yoshikawa N, Iijima K, Matsuyama S, Suzuki J, Kameda A, Okada S, Nakamura H (1990) Repeat renal biopsy in children with IgA nephropathy. Clin Nephrol 33:160–167PubMed

28.

Xu LX, Zhao MH (2005) Aberrantly glycosylated serum IgA1 are closely associated with pathologic phenotypes of IgA nephropathy. Kidney Int 68:167–172CrossRef

29.

Lau KK, Wyatt RJ, Gaber LW (2005) Purpura followed by proteinuria in a 7-year-old girl. Am J Kidney Dis 46:1140–1144CrossRef

Titel: Serum levels of galactose-deficient IgA in children with IgA nephropathy and Henoch-Schönlein purpura
verfasst von: Keith K. Lau
Robert J. Wyatt
Zina Moldoveanu
Milan Tomana
Bruce A. Julian
Ronald J. Hogg
Jeannette Y. Lee
Wen-Qiang Huang
Jiri Mestecky
Jan Novak
Publikationsdatum: 01.12.2007
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 12/2007
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-007-0623-y

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Serum levels of galactose-deficient IgA in children with IgA nephropathy and Henoch-Schönlein purpura

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