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Pediatric Nephrology

Erschienen in:

01.09.2009 | Review

Genetic and developmental basis for urinary tract obstruction

verfasst von: Feng Chen

Erschienen in: Pediatric Nephrology | Ausgabe 9/2009

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Abstract

Urinary tract obstruction results in obstructive nephropathy and uropathy. It is the most frequent cause of renal failure in infants and children. In the past two decades studies of transgenic models and humans have greatly enhanced our understanding of the genetic factors and developmental processes important in urinary tract obstruction. The emerging picture is that development of the urinary tract requires precise integration of a variety of progenitor cell populations of different embryonic origins. Such integration is controlled by an intricate signaling network that undergoes dynamic changes as the embryo develops. Most congenital forms of urinary tract obstruction result from the disruption of diverse factors and genetic pathways involved in these processes, especially in the morphogenesis of the urinary conduit or the functional aspects of the pyeloureteral peristaltic machinery.

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Titel: Genetic and developmental basis for urinary tract obstruction
verfasst von: Feng Chen
Publikationsdatum: 01.09.2009
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 9/2009
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-008-1072-y

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Genetic and developmental basis for urinary tract obstruction

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