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Pediatric Nephrology

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01.04.2011 | Educational Review

Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy

verfasst von: Lindsay Keir, Richard J. M. Coward

Erschienen in: Pediatric Nephrology | Ausgabe 4/2011

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Abstract

Glomerular thrombotic microangiopathy is a hallmark feature of haemolytic uraemic syndrome, the leading cause of acute renal failure in childhood. This paper is a review of the different mechanistic pathways that lead to this histological picture in the kidney. It will focus on atypical HUS and complement dysregulation, but will also highlight some other recent advances in our understanding of this condition, including the potential role of the molecule vascular endothelial growth factor- A (VEGF-A).

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Titel: Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy
verfasst von: Lindsay Keir
Richard J. M. Coward
Publikationsdatum: 01.04.2011
Verlag: Springer-Verlag
Erschienen in: Pediatric Nephrology / Ausgabe 4/2011
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-010-1637-4

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Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy

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