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Pediatric Nephrology

Erschienen in:

01.04.2011 | Review

Adverse consequences of accelerated neonatal growth: cardiovascular and renal issues

verfasst von: Umberto Simeoni, Isabelle Ligi, Christophe Buffat, Farid Boubred

Erschienen in: Pediatric Nephrology | Ausgabe 4/2011

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Abstract

Epidemiological and experimental studies show that the risk of cardiovascular and metabolic diseases at adulthood is inversely related to the weight at birth. Although with less evidence, low birth weight has been suggested to increase the risk of chronic kidney disease (CKD). It is well established that the developmental programming of arterial hypertension and of renal disease involves in particular renal factors, especially nephron endowment, which is reduced in low birth weight and maternal diabetes situations. Experimental studies, especially in rodents, have demonstrated the long-term influence of postnatal nutrition and/or postnatal growth on cardiovascular, metabolic and renal functions, while human data are scarce on this issue. Vascular and renal diseases appear to have a “multihits” origin, with reduced nephron number the initial hit and rapid postnatal growth the second hit. This review addresses the current understanding of the role of the kidney, both as a mechanism and as a target, in the developmental origins of adult disease theory, with a particular focus on the long-term effects of postnatal growth and nutrition.

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Titel: Adverse consequences of accelerated neonatal growth: cardiovascular and renal issues
verfasst von: Umberto Simeoni
Isabelle Ligi
Christophe Buffat
Farid Boubred
Publikationsdatum: 01.04.2011
Verlag: Springer-Verlag
Erschienen in: Pediatric Nephrology / Ausgabe 4/2011
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-010-1648-1

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Adverse consequences of accelerated neonatal growth: cardiovascular and renal issues

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