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Pediatric Nephrology

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01.06.2012 | Educational Review

Tubulointerstitial injury and the progression of chronic kidney disease

verfasst von: Kavita S. Hodgkins, H. William Schnaper

Erschienen in: Pediatric Nephrology | Ausgabe 6/2012

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Abstract

In chronic kidney disease (CKD), once injury from any number of disease processes reaches a threshold, there follows an apparently irreversible course toward decline in kidney function. The tubulointerstitium may play a key role in this common progression pathway. Direct injury, high metabolic demands, or stimuli from various other forms of renal dysfunction activate tubular cells. These, in turn, interact with interstitial tissue elements and inflammatory cells, causing further pathologic changes in the renal parenchyma. The tissue response to these changes thus generates a feed-forward loop of kidney injury and progressive loss of function. This article reviews the mechanisms of this negative cycle mediating CKD.

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Titel: Tubulointerstitial injury and the progression of chronic kidney disease
verfasst von: Kavita S. Hodgkins
H. William Schnaper
Publikationsdatum: 01.06.2012
Verlag: Springer-Verlag
Erschienen in: Pediatric Nephrology / Ausgabe 6/2012
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-011-1992-9

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