Erschienen in:
01.10.2012 | Brief Report
Membrano-proliferative glomerulonephritis, atypical hemolytic uremic syndrome, and a new complement factor H mutation: report of a case
verfasst von:
Elisa Gnappi, Marco Allinovi, Augusto Vaglio, Elena Bresin, Annalisa Sorosina, Francesco P. Pilato, Landino Allegri, Lucio Manenti
Erschienen in:
Pediatric Nephrology
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Ausgabe 10/2012
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Abstract
Background
Complement protein factor H (CFH) is a regulatory protein of the alternative complement pathway (AP); CFH mutations lead to a spectrum of different phenotypical manifestations of renal disease.
Case-Diagnosis/Treatment
We report the case of a boy with a novel CFH gene mutation who presented with a membranoproliferative (MPGN) pattern of glomerular injury and developed 2 years later atypical hemolytic uremic syndrome (aHUS); this description shows that CFH alteration leads to two different renal diseases in the same patient.
Conclusions
Our case suggests the possibility that complement dysregulation could determine different renal conditions, which may be part of the same disease spectrum. Early recognition of an evolution of glomerulopathies into aHUS may allow appropriate management and prevention of life-threatening consequences.