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Erschienen in: Pediatric Nephrology 12/2012

01.12.2012 | Original Article

Quality of life in children with end-stage renal disease based on a PedsQL ESRD module

verfasst von: Ki-Soo Park, Young Ju Hwang, Min Hyun Cho, Cheol Woo Ko, Il Soo Ha, Hee Gyung Kang, Hae Il Cheong, Young Seo Park, Yoon Jung Lee, Joo Hoon Lee, Hee Yeon Cho

Erschienen in: Pediatric Nephrology | Ausgabe 12/2012

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Abstract

Background

Health-related quality of life (HRQOL) is an essential subject for children with end-stage renal disease (ESRD) and their families.

Methods

We performed a cross-sectional investigation of HRQOL in children undergoing renal replacement therapies, such as dialysis and renal transplantation, using the 34-item Pediatric Quality of Life Inventory 3.0 End-Stage Renal Disease (PedsQL 3.0 ESRD) module. We assessed 92 ESRD patients aged 2–18 from four Korean university hospitals.

Results

The male:female ratio was 44:48, and the most common cause of ESRD was chronic glomerulonephritis. Fifty-five children were treated by dialysis, and 37 received renal transplantation. Transplant patients had better HRQOL than dialysis patients in two domains in parent proxy reports: “About my kidney disease” and “Worry.” In child self-reports, transplant patients had better HRQOL than dialysis patients in one domain: Treatment problems. However, there were no significant differences in total QOL scores between peritoneal dialysis (PD) and transplant patients in child self-reports. In addition, there were differences in the ESRD module scores between child self- and parent proxy reports. Children usually reported better QOL than their parents. Child self-reports showed significantly higher QOL scores than parent proxy reports in the domains of General fatigue, Family & peer interaction, and Worry. Children on PD self-reported a significantly higher QOL than children on hemodialysis (HD).

Conclusions

The PedsQL 3.0 ESRD module may be useful as an ESRD-specific instrument to evaluate HRQOL in children; however, a larger, longitudinal prospective study is warranted.
Literatur
1.
Zurück zum Zitat Goldstein SL, Graham N, Warady BA, Seikaly M, McDonald R, Burwinkle TM, Limbers CA, Varni JW (2008) Measuring health-related quality of life in children with ESRD: performance of the generic and ESRD-specific instrument of the Pediatric Quality of Life Inventory (PedsQL). Am J Kidney Dis 51:285–297PubMedCrossRef Goldstein SL, Graham N, Warady BA, Seikaly M, McDonald R, Burwinkle TM, Limbers CA, Varni JW (2008) Measuring health-related quality of life in children with ESRD: performance of the generic and ESRD-specific instrument of the Pediatric Quality of Life Inventory (PedsQL). Am J Kidney Dis 51:285–297PubMedCrossRef
2.
3.
Zurück zum Zitat Reinfjell T, Diseth TH, Veenstra M, Vikan A (2006) Measuring health-related quality of life in young adolescents: reliability and validity in the Norwegian version of the Pediatric Quality of Life Inventory 4.0 (PedsQL) generic core scales. Health Qual Life Outcomes 4:61PubMedCrossRef Reinfjell T, Diseth TH, Veenstra M, Vikan A (2006) Measuring health-related quality of life in young adolescents: reliability and validity in the Norwegian version of the Pediatric Quality of Life Inventory 4.0 (PedsQL) generic core scales. Health Qual Life Outcomes 4:61PubMedCrossRef
4.
Zurück zum Zitat Goldstein SL, Rosburg NM, Warady BA, Seikaly M, McDonald R, Limbers C, Varni JW (2009) Pediatric end stage renal disease health-related quality of life differs by modality: a PedsQL ESRD analysis. Pediatr Nephrol 24:1553–1560PubMedCrossRef Goldstein SL, Rosburg NM, Warady BA, Seikaly M, McDonald R, Limbers C, Varni JW (2009) Pediatric end stage renal disease health-related quality of life differs by modality: a PedsQL ESRD analysis. Pediatr Nephrol 24:1553–1560PubMedCrossRef
5.
Zurück zum Zitat Gerson A, Hwang W, Fiorenza J, Barth K, Kaskel F, Weiss L, Zelikovsky N, Fivush B, Furth S (2004) Anemia and health-related quality of life in adolescents with chronic kidney disease. Am J Kidney Dis 44:1017–1023PubMedCrossRef Gerson A, Hwang W, Fiorenza J, Barth K, Kaskel F, Weiss L, Zelikovsky N, Fivush B, Furth S (2004) Anemia and health-related quality of life in adolescents with chronic kidney disease. Am J Kidney Dis 44:1017–1023PubMedCrossRef
6.
Zurück zum Zitat Fadrowski J, Cole SR, Hwang W, Fiorenza J, Weiss RA, Gerson A, Furth SL (2006) Changes in physical and psychosocial functioning among adolescents with chronic kidney disease. Pediatr Nephrol 21:394–399PubMedCrossRef Fadrowski J, Cole SR, Hwang W, Fiorenza J, Weiss RA, Gerson A, Furth SL (2006) Changes in physical and psychosocial functioning among adolescents with chronic kidney disease. Pediatr Nephrol 21:394–399PubMedCrossRef
7.
Zurück zum Zitat Goldstein SL, Graham N, Burwinkle T, Warady B, Farrah R, Varni JW (2006) Health-related quality of life in pediatric patients with ESRD. Pediatr Nephrol 21:846–850PubMedCrossRef Goldstein SL, Graham N, Burwinkle T, Warady B, Farrah R, Varni JW (2006) Health-related quality of life in pediatric patients with ESRD. Pediatr Nephrol 21:846–850PubMedCrossRef
8.
Zurück zum Zitat Grootenhuis MA, Stam H, Last BF, Groothoff JW (2006) The impact of delayed development on the quality of life of adults with end-stage renal disease since childhood. Pediatr Nephrol 21:538–544PubMedCrossRef Grootenhuis MA, Stam H, Last BF, Groothoff JW (2006) The impact of delayed development on the quality of life of adults with end-stage renal disease since childhood. Pediatr Nephrol 21:538–544PubMedCrossRef
9.
Zurück zum Zitat McKenna AM, Keating LE, Vigneux A, Stevens S, Williams A, Geary DF (2006) Quality of life in children with chronic kidney disease-patient and caregiver assessments. Nephrol Dial Transplant 21:1899–1905PubMedCrossRef McKenna AM, Keating LE, Vigneux A, Stevens S, Williams A, Geary DF (2006) Quality of life in children with chronic kidney disease-patient and caregiver assessments. Nephrol Dial Transplant 21:1899–1905PubMedCrossRef
10.
Zurück zum Zitat Falger J, Landolt MA, Latal B, Ruth EM, Neuhaus TJ, Laube GF (2008) Outcome after renal transplantation. Part II: quality of life and psychosocial adjustment. Pediatr Nephrol 23:1347–1354PubMedCrossRef Falger J, Landolt MA, Latal B, Ruth EM, Neuhaus TJ, Laube GF (2008) Outcome after renal transplantation. Part II: quality of life and psychosocial adjustment. Pediatr Nephrol 23:1347–1354PubMedCrossRef
11.
Zurück zum Zitat Buyan N, Turkmen MA, Bilge I, Baskin E, Haberal M, Bilginer Y, Mir S, Emre S, Akman S, Ozkaya O, Fidan K, Alpay H, Kavukcu S, Sever L, Ozcakar ZB, Dogrucan N (2010) Quality of life in children with chronic kidney disease (with child and parent assessments). Pediatr Nephrol 25:1487–1496PubMedCrossRef Buyan N, Turkmen MA, Bilge I, Baskin E, Haberal M, Bilginer Y, Mir S, Emre S, Akman S, Ozkaya O, Fidan K, Alpay H, Kavukcu S, Sever L, Ozcakar ZB, Dogrucan N (2010) Quality of life in children with chronic kidney disease (with child and parent assessments). Pediatr Nephrol 25:1487–1496PubMedCrossRef
12.
Zurück zum Zitat Wiedebusch S, Konrad M, Foppe H, Reichwald-Klugger E, Schaefer F, Schreiber V, Muthny FA (2010) Health-related quality of life, psychosocial strains, and coping in parents of children with chronic renal failure. Pediatr Nephrol 25:1477–1485PubMedCrossRef Wiedebusch S, Konrad M, Foppe H, Reichwald-Klugger E, Schaefer F, Schreiber V, Muthny FA (2010) Health-related quality of life, psychosocial strains, and coping in parents of children with chronic renal failure. Pediatr Nephrol 25:1477–1485PubMedCrossRef
13.
Zurück zum Zitat Marciano RC, Soares CM, Diniz JS, Lima EM, Silva JM, Canhestro MR, Gazzinelli A, Melo CC, Dias CS, Simoes e Silva AC, Correa H, Oliveira EA (2011) Behavioral disorders and low quality of life in children and adolescents with chronic kidney disease. Pediatr Nephrol 26:281–290PubMedCrossRef Marciano RC, Soares CM, Diniz JS, Lima EM, Silva JM, Canhestro MR, Gazzinelli A, Melo CC, Dias CS, Simoes e Silva AC, Correa H, Oliveira EA (2011) Behavioral disorders and low quality of life in children and adolescents with chronic kidney disease. Pediatr Nephrol 26:281–290PubMedCrossRef
14.
Zurück zum Zitat Varni JW, Seid M, Kurtin PS (2001) PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. Med Care 39:800–812PubMedCrossRef Varni JW, Seid M, Kurtin PS (2001) PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. Med Care 39:800–812PubMedCrossRef
15.
Zurück zum Zitat McDonald SP, Craig JC (2004) Long-term survival of children with end-stage renal disease. N Engl J Med 350:2654–2662PubMedCrossRef McDonald SP, Craig JC (2004) Long-term survival of children with end-stage renal disease. N Engl J Med 350:2654–2662PubMedCrossRef
16.
Zurück zum Zitat Chiu MC, Ng CF, Lee LP, Lai WM, Lau SC (2007) Automated peritoneal dialysis in children and adolescents–benefits: a survey of patients and parents on health-related quality of life. Perit Dial Int 27(Suppl 2):S138–S142PubMed Chiu MC, Ng CF, Lee LP, Lai WM, Lau SC (2007) Automated peritoneal dialysis in children and adolescents–benefits: a survey of patients and parents on health-related quality of life. Perit Dial Int 27(Suppl 2):S138–S142PubMed
17.
Zurück zum Zitat Anthony SJ, Hebert D, Todd L, Korus M, Langlois V, Pool R, Robinson LA, Williams A, Pollock-BarZiv SM (2010) Child and parental perspectives of multidimensional quality of life outcomes after kidney transplantation. Pediatr Transplant 14:249–256PubMedCrossRef Anthony SJ, Hebert D, Todd L, Korus M, Langlois V, Pool R, Robinson LA, Williams A, Pollock-BarZiv SM (2010) Child and parental perspectives of multidimensional quality of life outcomes after kidney transplantation. Pediatr Transplant 14:249–256PubMedCrossRef
18.
Zurück zum Zitat Khan IH (1998) Comorbidity: the major challenge for survival and quality of life in end-stage renal disease. Nephrol Dial Transplant 13(Suppl 1):76–79PubMedCrossRef Khan IH (1998) Comorbidity: the major challenge for survival and quality of life in end-stage renal disease. Nephrol Dial Transplant 13(Suppl 1):76–79PubMedCrossRef
19.
Zurück zum Zitat United States Renal Data System (1992) Comorbid conditions and correlations with mortality risk among 3,399 incident hemodialysis patients. Am J Kidney Dis 20(Suppl 2):32–38 United States Renal Data System (1992) Comorbid conditions and correlations with mortality risk among 3,399 incident hemodialysis patients. Am J Kidney Dis 20(Suppl 2):32–38
20.
Zurück zum Zitat Eiam-Ong S, Sitprija V (2002) Comorbidities in patients with end-stage renal disease in developing countries. Artif Organs 26:753–756PubMedCrossRef Eiam-Ong S, Sitprija V (2002) Comorbidities in patients with end-stage renal disease in developing countries. Artif Organs 26:753–756PubMedCrossRef
21.
Zurück zum Zitat Gudex CM (1995) Health-related quality of life in endstage renal failure. Qual Life Res 4:359–366PubMedCrossRef Gudex CM (1995) Health-related quality of life in endstage renal failure. Qual Life Res 4:359–366PubMedCrossRef
22.
Zurück zum Zitat Khan IH, Campbell MK, Cantarovich D, Catto GR, Delcroix C, Edward N, Fontenaille C, Fleming LW, Gerlag PG, van Hamersvelt HW, Henderson IS, Koene RA, Papadimitriou M, Ritz E, Russell IT, Stier E, Tsakiris D, MacLeod AM (1996) Survival on renal replacement therapy in Europe: is there a centre effect’? Nephrol Dial Transplant 11:300–307PubMedCrossRef Khan IH, Campbell MK, Cantarovich D, Catto GR, Delcroix C, Edward N, Fontenaille C, Fleming LW, Gerlag PG, van Hamersvelt HW, Henderson IS, Koene RA, Papadimitriou M, Ritz E, Russell IT, Stier E, Tsakiris D, MacLeod AM (1996) Survival on renal replacement therapy in Europe: is there a centre effect’? Nephrol Dial Transplant 11:300–307PubMedCrossRef
23.
Zurück zum Zitat Van Manen JG, Korevaar JC, Dekker FW, Boeschoten EW, Bossuyt PM, Krediet RT, NECOSAD-Study Group (2003) Adjustment for comorbidity in studies on health status in ESRD patients: which comorbidity index to use? J Am Soc Nephrol 14:478–485PubMedCrossRef Van Manen JG, Korevaar JC, Dekker FW, Boeschoten EW, Bossuyt PM, Krediet RT, NECOSAD-Study Group (2003) Adjustment for comorbidity in studies on health status in ESRD patients: which comorbidity index to use? J Am Soc Nephrol 14:478–485PubMedCrossRef
Metadaten
Titel
Quality of life in children with end-stage renal disease based on a PedsQL ESRD module
verfasst von
Ki-Soo Park
Young Ju Hwang
Min Hyun Cho
Cheol Woo Ko
Il Soo Ha
Hee Gyung Kang
Hae Il Cheong
Young Seo Park
Yoon Jung Lee
Joo Hoon Lee
Hee Yeon Cho
Publikationsdatum
01.12.2012
Verlag
Springer-Verlag
Erschienen in
Pediatric Nephrology / Ausgabe 12/2012
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-012-2262-1

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