nach oben

Pediatric Nephrology

Erschienen in:

01.03.2013 | Original Article

Serum cystatin C predicts acute kidney injury in preterm neonates with respiratory distress syndrome

verfasst von: Ahmet Taner Elmas, Yilmaz Tabel, Özlem Nalbantoğlu Elmas

Erschienen in: Pediatric Nephrology | Ausgabe 3/2013

Einloggen, um Zugang zu erhalten

Abstract

Background

We aimed to compare serum cystatin C levels (sCysC) in preterm neonates with respiratory distress syndrome (RDS) with a control group and to investigate whether it could be used as a predictor for acute kidney injury (AKI).

Methods

sCysC was measured in 62 neonates with RDS (n = 28) and control neonates without RDS (n = 34), whose gestational ages (GA) were between 27 and 29 weeks (subgroup 1) and 30–32 weeks (subgroup 2). AKI was defined as oliguria and/or increase of serum creatinine. Blood samples were obtained on postnatal days (PND) 3 and 30. sCysC levels were determined by particle-enhanced nephelometric immunoassay.

Results

There were six neonates with AKI (RDS-AKI subgroup) and 22 neonates without AKI (RDS-no AKI subgroup) during the first 7 days. Although sCysC levels were lower in neonates with RDS than controls on PND3 in both GA subgroups, the differences were not significant. However, in neonates with RDS and AKI, sCysC levels were significantly higher than neonates with RDS but no AKI and neonates in the control group on PND3. sCysC level was found to have a statistically significant association with AKI development in preterm neonates with RDS.

Conclusions

sCysC is an independent predictor of AKI in preterm neonates with RDS.

Roberts D, Dalziel S (2006) Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev 3:CD004454PubMed

Lemons JA, Bauer CR, Oh W, Korones SB, Papile LA, Stoll BJ, Verter J, Temprosa M, Wright LL, Ehrenkranz RA, Fanaroff AA, Stark A, Carlo W, Tyson JE, Donovan EF, Shankaran S, Stevenson DK (2001) Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, January 1995 through December 1996. NICHD neonatal research network. Pediatrics 107:E1PubMedCrossRef

Koralkar R, Ambalavanan N, Levitan EB, McGwin G, Goldstein S, Askenazi D (2011) Acute kidney injury reduces survival in very low birth weight infants. Pediatr Res 69:354–358PubMedCrossRef

Askenazi DJ, Griffin R, McGwin G, Carlo W, Ambalavanan N (2009) Acute kidney injury is independently associated with mortality in very low birth weight infants: a matched case–control analysis. Pediatr Nephrol 24:991–997PubMedCrossRef

Andreoli SP (2004) Acute renal failure in the newborn. Semin Perinatol 28:112–123PubMedCrossRef

Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A (2007) Acute Kidney Injury Network (AKIN): report of an initiative to improve outcomes in acute kidney injury. Crit Care 11:R31PubMedCrossRef

Hoste EA, Kellum JA (2006) RIFLE criteria provide robust assessment of kidney dysfunction and correlate with hospital mortality. Crit Care Med 34:2016–2017PubMedCrossRef

Askenazi DJ, Ambalavanan N, Goldstein SL (2009) Acute kidney injury in critically ill newborns: what do we know? what do we need to learn? Pediatr Nephrol 24:265–274PubMedCrossRef

Gallini F, Maggio L, Romagnoli C, Marrocco G, Tortorolo G (2000) Progression of renal function in preterm neonates with gestational age < or = 32 weeks. Pediatr Nephrol 15:119–124PubMedCrossRef

10.

Brion LP, Fleischman AR, McCarton C, Schwartz GJ (1986) A simple estimate of glomerular filtration rate in low birth weight infants during the first year of life: noninvasive assessment of body composition and growth. J Pediatr 109:698–707PubMedCrossRef

11.

Parikh CR, Lu JC, Coca SG, Devarajan P (2010) Tubular proteinuria in acute kidney injury: a critical evaluation of current status and future promise. Ann Clin Biochem 47:301–312PubMedCrossRef

12.

Devarajan P (2008) The future of pediatric acute kidney injury management–biomarkers. Semin Nephrol 28:493–498PubMedCrossRef

13.

Bagshaw SM, Bellomo R (2007) Early diagnosis of acute kidney injury. Curr Opin Crit Care 13:638–644PubMedCrossRef

14.

Filler G, Bökenkamp A, Hofmann W, Le Bricon T, Martínez-Brú C, Grubb A (2005) Cystatin C as a marker of GFR-history, indications, and future research. Clin Biochem 38:1–8PubMedCrossRef

15.

Sharma AP, Kathiravelu A, Nadarajah R, Yasin A, Filler G (2009) Body mass does not have a clinically relevant effect on cystatin C eGFR in children. Nephrol Dial Transplant 24:470–474PubMedCrossRef

16.

Cataldi L, Mussap M, Bertelli L, Ruzzante N, Fanos V, Plebani M (1999) Cystatin C in healthy women at term pregnancy and in their infant newborns: relationship between maternal and neonatal serum levels and reference values. Am J Perinatol 16:287–295PubMedCrossRef

17.

Herrero-Morín JD, Málaga S, Fernández N, Rey C, Diéguez MA, Solís G, Concha A, Medina A (2007) Cystatin C and beta2-microglobulin: markers of glomerular filtration in critically ill children. Crit Care 11:R59PubMedCrossRef

18.

Krawczeski CD, Vandevoorde RG, Kathman T, Bennett MR, Woo JG, Wang Y, Griffiths RE, Devarajan P (2010) Serum cystatin C is an early predictive biomarker of acute kidney injury after pediatric cardiopulmonary bypass. Clin J Am Soc Nephrol 5:1552–1557PubMedCrossRef

19.

Ahlström A, Tallgren M, Peltonen S, Pettilä V (2004) Evolution and predictive power of serum cystatin C in acute renal failure. Clin Nephrol 62:344–350PubMed

20.

Herget-Rosenthal S, Marggraf G, Hüsing J, Göring F, Pietruck F, Janssen O, Philipp T, Kribben A (2004) Early detection of acute renal failure by serum cystatin C. Kidney Int 66:1115–1122PubMedCrossRef

21.

Nejat M, Pickering JW, Walker RJ, Endre ZH (2010) Rapid detection of acute kidney injury by plasma cystatin C in the intensive care unit. Nephrol Dial Transplant 25:3283–3289PubMedCrossRef

22.

Finney H, Newman DJ, Gruber W, Merle P, Price CP (1997) Initial evaluation of cystatin C measurement by particle-enhanced immunonephelometry on the Behring nephelometer systems (BNA, BN II). Clin Chem 43:1016–1022PubMed

23.

Akcan-Arikan A, Zappitelli M, Loftis LL, Washburn KK, Jefferson LS, Goldstein SL (2007) Modified RIFLE criteria in critically ill children with acute kidney injury. Kidney Int 71:1028–1035PubMedCrossRef

24.

Langlois V (2008) Laboratory evaluation at different ages. In: Geary D, Shaefer F (eds) Comprehensive pediatric nephrology, 1st edn. Mosby Elsevier, Philadelphia, pp 39–54CrossRef

25.

Hentschel R, Lodige B, Bulla M (1996) Renal insufficiency in the neonatal period. Clin Nephrol 46:54–58PubMed

26.

Cataldi L, Leone R, Moretti U, De Mitri B, Fanos V, Ruggeri L, Sabatino G, Torcasio F, Zanardo V, Attardo G, Riccobene F, Martano C, Benini D, Cuzzolin L (2005) Potential risk factors for the development of acute renal failure in preterm newborn infants: a case–control study. Arch Dis Child Fetal Neonatal Ed 90:F514–F519PubMedCrossRef

27.

Vasarhelyi B, Toth-Heyn P, Treszl A, Tulassay T (2005) Genetic polymorphisms and risk for acute renal failure in preterm neonates. Pediatr Nephrol 20:132–135PubMedCrossRef

28.

Rodriguez-Soriano J, Aguirre M, Oliveros R, Vallo A (2005) Long-term renal follow-up of extremely low birth weight infants. Pediatr Nephrol 20:579–584PubMedCrossRef

29.

Mortazavi F, Hosseinpour Sakha S, Nejati N (2009) Acute kidney failure in neonatal period. Iran J Kidney Dis 3:136–140PubMed

30.

Li Y, Fu C, Zhou X, Xiao Z, Zhu X, Jin M, Li X, Feng X (2012) Urine interleukin-18 and cystatin-C as biomarkers of acute kidney injury in critically ill neonates. Pediatr Nephrol 27:851–860PubMedCrossRef

31.

Karlowicz MG, Adelman RD (1995) Nonoliguric and oliguric acute renal failure in asphyxiated term neonates. Pediatr Nephrol 9:718–722PubMedCrossRef

32.

Cuzzolin L, Fanos V, Pinna B, di Marzio M, Perin M, Tramontozzi P, Tonetto P, Cataldi L (2006) Postnatal renal function in preterm newborns: a role of diseases, drugs and therapeutic interventions. Pediatr Nephrol 21:931–938PubMedCrossRef

33.

Tulassay T, Vasarhelyi B (2002) Birth weight and renal function. Curr Opin Nephrol Hypertens 11:347–352PubMedCrossRef

34.

Finney H, Newman DJ, Thakkar H, Fell JM, Price CP (2000) Reference ranges for plasma cystatin C and creatinine measurements in premature infants, neonates, and older children. Arch Dis Child 82:71–75PubMedCrossRef

35.

Bariciak E, Yasin A, Harrold J, Walker M, Lepage N, Filler G (2011) Preliminary reference intervals for cystatin C and beta-trace protein in preterm and term neonates. Clin Biochem 44:1156–1159PubMedCrossRef

36.

Bartelink IH, Rademaker CM, Schobben AF, van den Anker JN (2006) Guidelines on paediatric dosing on the basis of developmental physiology and pharmacokinetic considerations. Clin Pharmacokinet 45:1077–1097PubMedCrossRef

37.

Filler G, Browne R, Seikaly MG (2003) Glomerular filtration rate as a putative ‘surrogate end-point’ for renal transplant clinical trials in children. Pediatr Transplant 7:18–24PubMedCrossRef

38.

Roos JF, Doust J, Tett SE, Kirkpatrick CM (2007) Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children-a meta-analysis. Clin Biochem 40:383–391PubMedCrossRef

39.

Bagshaw SM, Bellomo R (2010) Cystatin C in acute kidney injury. Curr Opin Crit Care. doi:10.1097/MCC.0b013e32833e8412

40.

Haase-Fielitz A, Bellomo R, Devarajan P, Story D, Matalanis G, Dragun D, Haase M (2009) Novel and conventional serum biomarkers predicting acute kidney injury in adult cardiac surgery—a prospective cohort study. Crit Care Med 37:553–560PubMedCrossRef

41.

Sarafidis K, Tsepkentzi E, Agakidou E, Diamanti E, Taparkou A, Soubasi V, Papachristou F, Drossou V (2012) Serum and urine acute kidney injury biomarkers in asphyxiated neonates. Pediatr Nephrol 27:1575–1582PubMedCrossRef

Titel: Serum cystatin C predicts acute kidney injury in preterm neonates with respiratory distress syndrome
verfasst von: Ahmet Taner Elmas
Yilmaz Tabel
Özlem Nalbantoğlu Elmas
Publikationsdatum: 01.03.2013
Verlag: Springer-Verlag
Erschienen in: Pediatric Nephrology / Ausgabe 3/2013
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-012-2331-5

Neu im Fachgebiet Pädiatrie

16.04.2024 | Störungen der Geschlechtsidentität | Nachrichten

Update Pädiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Serum cystatin C predicts acute kidney injury in preterm neonates with respiratory distress syndrome

Abstract

Background

Methods

Results

Conclusions

Neu im Fachgebiet Pädiatrie

Zunahme von Geschlechtsinkongruenz und -dysphorie registriert

Stillende Frauen haben geringeres kardiovaskuläres Risiko

Komplexes Krankheitsbild zwischen Haut und Lunge – und das mit 13 Jahren

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Update Pädiatrie

Springer Medizin

Abstract

Background

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2013

Renal complications following lung and heart-lung transplantation

Treatment of steroid-sensitive nephrotic syndrome: new guidelines from KDIGO

Cytokines in chronic kidney disease: potential link of MCP-1 and dyslipidemia in glomerular diseases

An adolescent girl with hypertension and neuropsychiatric symptoms: Questions

Pediatric acute kidney injury assessed by pRIFLE as a prognostic factor in the intensive care unit

Mitochondrial disease—an important cause of end-stage renal failure

Neu im Fachgebiet Pädiatrie

Zunahme von Geschlechtsinkongruenz und -dysphorie registriert

Stillende Frauen haben geringeres kardiovaskuläres Risiko

Komplexes Krankheitsbild zwischen Haut und Lunge – und das mit 13 Jahren

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Update Pädiatrie