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01.06.2013 | Brief Report

Therapeutic plasma exchange in the treatment of exertional heat stroke and multiorgan failure

verfasst von: Vimal Master Sankar Raj, Amanda Alladin, Brent Pfeiffer, Chryso Katsoufis, Marissa Defreitas, Alicia Edwards-Richards, Jayanthi Chandar, Wacharee Seeherunvong, Gwenn McLaughlin, Gaston Zilleruelo, Carolyn L. Abitbol

Erschienen in: Pediatric Nephrology | Ausgabe 6/2013

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Abstract

Background

Exertional heat stroke (EHS) results in a constellation of systemic inflammatory responses resulting in multiorgan failure and an extremely high mortality.

Case Diagnosis and Treatments

We present the case of an 11-year-old obese male who suffered EHS with rhabdomyolysis and concurrent renal, pulmonary, and hepatic failure. Conventional therapies including continuous veno-venous hemodiafiltration (CVVHDF) were ineffective in preventing ongoing deterioration in clinical status. Liver biopsy was reported as “extensive hepatocyte ballooning” and liver-kidney transplantation was tentatively planned.

Conclusions

The addition of therapeutic plasma exchange using the Prismaflex® system (Gambro, Lakewood, CO, USA) resulted in a reversal of the inflammatory process and recovery from multiorgan failure. Liver biopsy was not a reliable indicator of irreversible hepatic injury.

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Titel: Therapeutic plasma exchange in the treatment of exertional heat stroke and multiorgan failure
verfasst von: Vimal Master Sankar Raj
Amanda Alladin
Brent Pfeiffer
Chryso Katsoufis
Marissa Defreitas
Alicia Edwards-Richards
Jayanthi Chandar
Wacharee Seeherunvong
Gwenn McLaughlin
Gaston Zilleruelo
Carolyn L. Abitbol
Publikationsdatum: 01.06.2013
Verlag: Springer-Verlag
Erschienen in: Pediatric Nephrology / Ausgabe 6/2013
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-013-2409-8

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Therapeutic plasma exchange in the treatment of exertional heat stroke and multiorgan failure

Abstract

Background

Case Diagnosis and Treatments

Conclusions

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Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

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Update Pädiatrie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Background

Case Diagnosis and Treatments

Conclusions

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