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01.01.2015 | Original Article

Determination of early urinary renal injury markers in obese children

verfasst von: Nilufer Goknar, Faruk Oktem, Ilker Tolga Ozgen, Emel Torun, Mehmet Kuçukkoc, Aysegul Dogan Demir, Yasar Cesur

Erschienen in: Pediatric Nephrology | Ausgabe 1/2015

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Abstract

Background

Obesity is an important health issue, the prevalence of which is increasing in childhood. The aim of this study was to examine urinary renal injury markers in order to determine the renal effect of obesity and its comorbidities in a pediatric population.

Methods

Eighty-four obese children and 64 healthy control subjects were enrolled in the study. We checked their urine using N-acetyl-beta-d-glucosaminidase (NAG), neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and microalbumin as renal injury markers. Associations of renal damage markers with hypertension, an impaired glucose tolerance test, and insulin resistance were assessed.

Results

Obese individuals had higher urinary NAG and KIM-1 values compared to those of healthy controls (p = 0.027, p = 0.026). There was no difference in urinary NGAL between obese and lean subjects (p = 0.885). Urinary renal injury markers were not statistically different in the obese group when checked for impaired glucose tolerance, insulin resistance, and hypertension (p > 0.05).

Conclusions

This study shows that urinary NAG and KIM-1 could be used as a screening method for detection of early renal damage in obese children.

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Titel: Determination of early urinary renal injury markers in obese children
verfasst von: Nilufer Goknar
Faruk Oktem
Ilker Tolga Ozgen
Emel Torun
Mehmet Kuçukkoc
Aysegul Dogan Demir
Yasar Cesur
Publikationsdatum: 01.01.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 1/2015
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-014-2829-0

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Springer Medizin

Determination of early urinary renal injury markers in obese children

Abstract

Background

Methods

Results

Conclusions

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Springer Medizin

Abstract

Background

Methods

Results

Conclusions

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