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Pediatric Nephrology

Erschienen in:

01.10.2015 | Educational Review

Recurrent focal segmental glomerulosclerosis after kidney transplantation

verfasst von: Rebecca Trachtman, Simranjeet S. Sran, Howard Trachtman

Erschienen in: Pediatric Nephrology | Ausgabe 10/2015

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Abstract

Focal segmental glomerulosclerosis (FSGS) is an important cause of glomerular disease in children and adolescents and nearly 50 % of affected patients will progress to end-stage kidney disease over a 5 to 10-year period. Unfortunately, there is no established treatment for disease in the native kidney. Moreover, up to 55 % of patients develop recurrent disease after receiving a kidney transplant, with a substantially higher risk in patients who have already experienced recurrent disease in a prior transplant. A number of clinical and laboratory factors have been identified as risk factors for this complication. In addition, new investigations into podocyte biology and circulating permeability factors have shed light on the cause of recurrent the disease. While a number of novel therapeutic agents have been applied in the management of this problem, there still is no proven treatment. In this review, we summarize recent advances in the epidemiology, pathophysiology, and treatment of recurrent FSGS in pediatric patients who have received a kidney transplant.

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Titel: Recurrent focal segmental glomerulosclerosis after kidney transplantation
verfasst von: Rebecca Trachtman
Simranjeet S. Sran
Howard Trachtman
Publikationsdatum: 01.10.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 10/2015
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-015-3062-1

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Recurrent focal segmental glomerulosclerosis after kidney transplantation

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