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Erschienen in: Pediatric Nephrology 2/2019

27.07.2018 | Clinical Quiz

A child with arthritis, skin rash, abdominal pain and nephritis: searching beyond Henoch–Schönlein purpura—Answers

verfasst von: William Chotas, Mohammad Ilyas, Asad Tolaymat

Erschienen in: Pediatric Nephrology | Ausgabe 2/2019

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Excerpt

1.
Based on clinical presentation, the most likely diagnosis is Henoch–Schönlein purpura (HSP); however, other causes of pauci-immune vasculitis should be considered in the differential diagnosis.
 
2.
The renal biopsy showed pauci-immune necrotizing and crescentic glomerulonephritis with global glomerulosclerosis, interstitial fibrosis, and tubular atrophy. The glomerulonephritis demonstrated mild activity and moderate chronicity. There was no evidence of immune complex-mediated disease.
 
3.
ANCA testing was performed and she tested positive for IgG C-ANCA (anti-proteinase 3), and negative for myeloperoxidase antibodies.
 
4.
Based on renal biopsy and being ANCA positive, the patient was given pulse methylprednisolone, mycophenolate mofetil, and rituximab.
 
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Metadaten
Titel
A child with arthritis, skin rash, abdominal pain and nephritis: searching beyond Henoch–Schönlein purpura—Answers
verfasst von
William Chotas
Mohammad Ilyas
Asad Tolaymat
Publikationsdatum
27.07.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Nephrology / Ausgabe 2/2019
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-018-4009-0

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