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Erschienen in: Pediatric Nephrology 5/2020

13.01.2020 | Original Article

Grip strength in children with chronic kidney disease

verfasst von: Julien Hogan, Michael F. Schneider, Rima Pai, Michelle R. Denburg, Amy Kogon, Ellen R. Brooks, Frederick J. Kaskel, Kimberly J. Reidy, Jeffrey M. Saland, Bradley A. Warady, Susan L. Furth, Rachel E. Patzer, Larry A. Greenbaum

Erschienen in: Pediatric Nephrology | Ausgabe 5/2020

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Abstract

Background

The relationship between muscle strength and chronic kidney disease (CKD) in children is unknown. This study aims to quantify the association between grip strength (GS) and kidney function and to explore factors associated with grip strength in children and adolescents with CKD.

Methods

We included 411 children (699 GS assessments) of the Chronic Kidney Disease in Children (CKiD) study. They were matched by age, sex, and height to a healthy control from the National Health and Nutrition Examination Survey to quantify the relationship between GS and CKD. Linear mixed models were used to identify factors associated with GS among CKD patients.

Results

Median GS z-score was − 0.72 (IQR − 1.39, 0.11) among CKD patients with CKD stages 2 through 5 having significantly lower GS than CKD stage 1. Compared with healthy controls, CKiD participants had a decreased GS z-score (− 0.53 SD lower, 95% CI − 0.67 to − 0.39) independent of race/ethnicity and body mass index. Factors associated with reduced GS included longer duration of CKD, pre-pubertal status, delayed puberty, neuropsychiatric comorbidities, need of feeding support, need for alkali therapy, and hemoglobin level. Decreased GS was also associated with both a lower frequency and intensity of physical activity.

Conclusions

CKD is associated with impaired muscle strength in children independent of growth retardation and BMI. Exposure to CKD for a prolonged time is associated with impaired muscle strength. Potential mediators of the impact of CKD on muscle strength include growth retardation, acidosis, poor nutritional status, and low physical activity. Additional studies are needed to assess the efficacy of interventions targeted at these risk factors.
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Metadaten
Titel
Grip strength in children with chronic kidney disease
verfasst von
Julien Hogan
Michael F. Schneider
Rima Pai
Michelle R. Denburg
Amy Kogon
Ellen R. Brooks
Frederick J. Kaskel
Kimberly J. Reidy
Jeffrey M. Saland
Bradley A. Warady
Susan L. Furth
Rachel E. Patzer
Larry A. Greenbaum
Publikationsdatum
13.01.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Nephrology / Ausgabe 5/2020
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-019-04461-x

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