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Erschienen in: Supportive Care in Cancer 12/2010

01.12.2010 | Original Article

Physical activity level as an outcome measure for use in cancer cachexia trials: a feasibility study

verfasst von: Matthew Maddocks, Anthony Byrne, Colin D. Johnson, Richard H. Wilson, Kenneth C. H. Fearon, Andrew Wilcock

Erschienen in: Supportive Care in Cancer | Ausgabe 12/2010

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Abstract

Purpose

Cancer cachexia impacts on treatment options, quality of life and survival. New treatments are emerging but need to be assessed using outcomes which patients find meaningful. One approach is the measurement of physical activity levels by small lightweight monitors, but experience is limited in cancer patients.

Materials and methods

This study formally assessed the acceptability of wearing an ActivPAL™ monitor for 1 week using compliance based on analysis of movement data. The optimal period of monitoring was explored by comparing mean values of daily step count and energy expenditure (EE) for 2 or 4 and 6 days of monitoring. The relationships between step count, stepping EE and non-stepping EE were also explored.

Results

Sixty patients (mean age 68 years; Eastern Cooperative Oncology Group performance status 0–2) with lung or upper gastrointestinal cancer took part. All but one found that the monitor acceptable and mean [95% CI] compliance was 98% [94–100%]. Median daily step counts and EE scores over 2 or 4 days were significantly higher than those from 6 days (p ≤ 0.01). Step count was strongly related to stepping and non-stepping EE (r = −0.911, p < 0.01).

Conclusions

The ActivPAL™ is acceptable to patients with outcomes obtained over 6 days recommended for use in future studies.
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Metadaten
Titel
Physical activity level as an outcome measure for use in cancer cachexia trials: a feasibility study
verfasst von
Matthew Maddocks
Anthony Byrne
Colin D. Johnson
Richard H. Wilson
Kenneth C. H. Fearon
Andrew Wilcock
Publikationsdatum
01.12.2010
Verlag
Springer-Verlag
Erschienen in
Supportive Care in Cancer / Ausgabe 12/2010
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-009-0776-2

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