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01.04.2012 | Original Article

Impaired physiological function and health-related QOL in patients before hematopoietic stem-cell transplantation

verfasst von: Shinichiro Morishita, Katsuji Kaida, Kazuhiro Ikegame, Satoshi Yoshihara, Kyoko Taniguchi, Masaya Okada, Norihiko Kodama, Hiroyasu Ogawa, Kazuhisa Domen

Erschienen in: Supportive Care in Cancer | Ausgabe 4/2012

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Abstract

Purpose

Patients' physiological functions and health-related quality of life (QOL) are useful for planning physical therapy after allogeneic hematopoietic stem-cell transplantation (allo-HSCT), but have not been extensively examined prior to transplantation. We investigated whether physiological functions and health-related QOL were reduced in patients before undergoing allo-HSCT.

Methods

All patients (n = 110) who underwent allo-HSCT between May 2007 and April 2010 at Hyogo College of Medicine Hospital were included in this study and evaluated for hand-grip and knee-extensor strength; 6-min walk test (6MWT) and health-related QOL (SF-36) were also used for evaluation.

Results

Grip strength, knee-extensor strength, 6MWT, and all eight SF-36 health-related QOL subscale scores significantly decreased in HSCT patients compared to population norms (all, P < 0.01). Health-related QOL is associated with various confounding factors such as fatigue and sex. Loss of physiological function is also associated with confounding factors; one such association was found between skeletal muscle strength and previous HSCT treatment.

Conclusion

Health-related QOL and loss of physiological function have a variety confounding factors. Patients scheduled for HSCT may have physiological weaknesses prior to transplant, which need to be considered when planning an exercise regimen during and after transplantation.

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Titel: Impaired physiological function and health-related QOL in patients before hematopoietic stem-cell transplantation
verfasst von: Shinichiro Morishita
Katsuji Kaida
Kazuhiro Ikegame
Satoshi Yoshihara
Kyoko Taniguchi
Masaya Okada
Norihiko Kodama
Hiroyasu Ogawa
Kazuhisa Domen
Publikationsdatum: 01.04.2012
Verlag: Springer-Verlag
Erschienen in: Supportive Care in Cancer / Ausgabe 4/2012
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-011-1156-2

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Impaired physiological function and health-related QOL in patients before hematopoietic stem-cell transplantation

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