Skip to main content
Erschienen in: Supportive Care in Cancer 4/2012

01.04.2012 | Short Communication

Quality of end-of-life care for patients with metastatic non-small-cell lung cancer in general wards and palliative care units in Japan

verfasst von: Kikuo Nakano, Takashi Yoshida, Junko Furutama, Shoji Sunada

Erschienen in: Supportive Care in Cancer | Ausgabe 4/2012

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Patients with lung cancer in Japan often receive aggressive care near the end of life and die in an acute care hospital. We describe the differences in end-of-life care for metastatic non-small-cell lung cancer (NSCLC) patients between general wards and a palliative care unit (PCU).

Methods

A retrospective analysis was conducted using data from patients who received at least second-line chemotherapy between 2002 and 2007 in a single institute. Among 72 eligible patients, we categorised patients into two groups, those who died in general wards (n = 57) and those who died in the PCU (n = 15), and examined end-of-life care including chemotherapy, do-not-resuscitate (DNR) decision making and treatment in the last 48 h of life.

Results

Mean number of days between the last chemotherapy and death was shorter in general wards than in the PCU (P = 0.019). Furthermore, 25% of patients in general wards received chemotherapy within the last 2 weeks of life. Rates of multiple hospitalisations in the last month of life appeared higher in general wards than in the PCU. Mean number of days between documentation of DNR and death was shorter in general wards than in the PCU (P = 0.0010). Patients in general wards received a greater volume of hydration than those in the PCU (P < 0.001).

Conclusions

Patients with metastatic NSCLC in general wards receive inappropriate care near the end of life. Further studies are needed to develop interventions for making decisions regarding end-of-life care.
Literatur
1.
2.
Zurück zum Zitat The SUPPORT Principal Investigators (1995) A controlled trial to improve care for seriously III hospitalised patients: the study to understand prognoses and preferences for outcomes and risks of treatments (SUPPORT). JAMA 274:1591–1598CrossRef The SUPPORT Principal Investigators (1995) A controlled trial to improve care for seriously III hospitalised patients: the study to understand prognoses and preferences for outcomes and risks of treatments (SUPPORT). JAMA 274:1591–1598CrossRef
3.
Zurück zum Zitat Toscani F, Di Giulio P, Brunelli C, Miccinesi G, Laquintana D (2005) How people die in hospital general wards: a descriptive study. J Pain Symptom Manage 30:33–40PubMedCrossRef Toscani F, Di Giulio P, Brunelli C, Miccinesi G, Laquintana D (2005) How people die in hospital general wards: a descriptive study. J Pain Symptom Manage 30:33–40PubMedCrossRef
4.
Zurück zum Zitat Solloway M, Lafrance S, Bakitas M, Gerken M (2005) A chart review of seven hundred eighty-two deaths in hospitals, nursing homes, and hospice/home care. J Palliat Med 8:789–796PubMedCrossRef Solloway M, Lafrance S, Bakitas M, Gerken M (2005) A chart review of seven hundred eighty-two deaths in hospitals, nursing homes, and hospice/home care. J Palliat Med 8:789–796PubMedCrossRef
5.
Zurück zum Zitat Paice JA, Muir JC, Shott S (2004) Palliative care at the end of life: comparing quality in diverse settings. Am J Hosp Palliat Care 21:19–27PubMedCrossRef Paice JA, Muir JC, Shott S (2004) Palliative care at the end of life: comparing quality in diverse settings. Am J Hosp Palliat Care 21:19–27PubMedCrossRef
6.
Zurück zum Zitat Earle CC, Park ER, Lai B, Weeks JC, Ayanian JZ, Block S (2003) Identifying potential indicators of the quality of end-of-life cancer care from administrative data. J Clin Oncol 21:1133–1138PubMedCrossRef Earle CC, Park ER, Lai B, Weeks JC, Ayanian JZ, Block S (2003) Identifying potential indicators of the quality of end-of-life cancer care from administrative data. J Clin Oncol 21:1133–1138PubMedCrossRef
7.
Zurück zum Zitat Earle CC, Landrum MB, Souza JM, Neville BA, Weeks JC, Ayanian JZ (2008) Aggressiveness of cancer care near the end of life: is it a quality-of-care issue? J Clin Oncol 26:3860–3866PubMedCrossRef Earle CC, Landrum MB, Souza JM, Neville BA, Weeks JC, Ayanian JZ (2008) Aggressiveness of cancer care near the end of life: is it a quality-of-care issue? J Clin Oncol 26:3860–3866PubMedCrossRef
8.
Zurück zum Zitat Tang ST, Wu SC, Hung YN, Huang EW, Chen JS, Liu TW (2009) Trends in quality of end-of-life care for Taiwanese cancer patients who died in 2000–2006. Ann Oncol 20:343–348PubMedCrossRef Tang ST, Wu SC, Hung YN, Huang EW, Chen JS, Liu TW (2009) Trends in quality of end-of-life care for Taiwanese cancer patients who died in 2000–2006. Ann Oncol 20:343–348PubMedCrossRef
9.
Zurück zum Zitat Sato K, Miyashita M, Morita T, Sanjo M, Shima Y, Uchitomi Y (2008) Quality of end-of-life treatment for cancer patients in general wards and the palliative care unit at a regional cancer center in Japan: a retrospective chart review. Support Care Cancer 16:113–122PubMedCrossRef Sato K, Miyashita M, Morita T, Sanjo M, Shima Y, Uchitomi Y (2008) Quality of end-of-life treatment for cancer patients in general wards and the palliative care unit at a regional cancer center in Japan: a retrospective chart review. Support Care Cancer 16:113–122PubMedCrossRef
10.
Zurück zum Zitat Degner LF, Sloan JA (1995) Symptom distress in newly diagnosed ambulatory cancer patients and as a predictor of survival in lung cancer. J Pain Symptom Manage 10:423–431PubMedCrossRef Degner LF, Sloan JA (1995) Symptom distress in newly diagnosed ambulatory cancer patients and as a predictor of survival in lung cancer. J Pain Symptom Manage 10:423–431PubMedCrossRef
11.
Zurück zum Zitat Non-small Cell Lung Cancer Collaborative Group (1995) Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. BMJ 311:899–909CrossRef Non-small Cell Lung Cancer Collaborative Group (1995) Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. BMJ 311:899–909CrossRef
12.
Zurück zum Zitat Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA et al (2010) Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 363:733–742PubMedCrossRef Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA et al (2010) Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 363:733–742PubMedCrossRef
13.
Zurück zum Zitat Murillo JR Jr, Koeller J (2006) Chemotherapy given near the end of life by community oncologists for advanced non-small cell lung cancer. Oncologist 11:1095–1099PubMedCrossRef Murillo JR Jr, Koeller J (2006) Chemotherapy given near the end of life by community oncologists for advanced non-small cell lung cancer. Oncologist 11:1095–1099PubMedCrossRef
14.
Zurück zum Zitat Temel JS, McCannon J, Greer JA, Jackson VA, Ostler P, Pirl WF et al (2008) Aggressiveness of care in a prospective cohort of patients with advanced NSCLC. Cancer 113:826–833PubMedCrossRef Temel JS, McCannon J, Greer JA, Jackson VA, Ostler P, Pirl WF et al (2008) Aggressiveness of care in a prospective cohort of patients with advanced NSCLC. Cancer 113:826–833PubMedCrossRef
15.
Zurück zum Zitat Connor SR, Pyenson B, Fitch K, Spence C, Iwasaki K (2007) Comparing hospice and non-hospice patient survival among patients who die within a 3-year window. J Pain Symptom Manage 33:238–246PubMedCrossRef Connor SR, Pyenson B, Fitch K, Spence C, Iwasaki K (2007) Comparing hospice and non-hospice patient survival among patients who die within a 3-year window. J Pain Symptom Manage 33:238–246PubMedCrossRef
16.
Zurück zum Zitat Harrington SE, Smith TJ (2008) The role of chemotherapy at the end of life: “when is enough, enough”? JAMA 299:2667–2678PubMedCrossRef Harrington SE, Smith TJ (2008) The role of chemotherapy at the end of life: “when is enough, enough”? JAMA 299:2667–2678PubMedCrossRef
17.
Zurück zum Zitat Mack JW, Weeks JC, Wright AA, Block SD, Prigerson HG, Prigerson HG (2010) End-of-life discussions, goal attainment, and distress at the end of life: predictors and outcomes of receipt of care consistent with preferences. J Clin Oncol 28:1203–1208PubMedCrossRef Mack JW, Weeks JC, Wright AA, Block SD, Prigerson HG, Prigerson HG (2010) End-of-life discussions, goal attainment, and distress at the end of life: predictors and outcomes of receipt of care consistent with preferences. J Clin Oncol 28:1203–1208PubMedCrossRef
18.
Zurück zum Zitat Zhang B, Wright AA, Huskamp HA, Nilsson ME, Maciejewski ML, Earle CC et al (2009) Health care costs in the last week of life: associations with end-of-life conversations. Arch Intern Med 169:480–488PubMedCrossRef Zhang B, Wright AA, Huskamp HA, Nilsson ME, Maciejewski ML, Earle CC et al (2009) Health care costs in the last week of life: associations with end-of-life conversations. Arch Intern Med 169:480–488PubMedCrossRef
19.
Zurück zum Zitat Jonsson PV, McNamee M, Campion EW (1988) The “do-not-resuscitate” order. A profile of its changing use. Arch Intern Med 148:2373–2375PubMedCrossRef Jonsson PV, McNamee M, Campion EW (1988) The “do-not-resuscitate” order. A profile of its changing use. Arch Intern Med 148:2373–2375PubMedCrossRef
20.
Zurück zum Zitat Gleeson K, Wise S (1990) The do-not-resuscitate order. Still too little, too late. Arch Intern Med 150:1057–1060PubMedCrossRef Gleeson K, Wise S (1990) The do-not-resuscitate order. Still too little, too late. Arch Intern Med 150:1057–1060PubMedCrossRef
21.
Zurück zum Zitat Berlowitz DR, Wilking SV, Moskowitz MA (1991) Do-not-resuscitate orders at a chronic care hospital. J Am Geriatr Soc 39:472–476PubMed Berlowitz DR, Wilking SV, Moskowitz MA (1991) Do-not-resuscitate orders at a chronic care hospital. J Am Geriatr Soc 39:472–476PubMed
22.
Zurück zum Zitat Ruhnke GW, Wilson SR, Akamatsu T, Kinoue T, Takashima Y, Goldstein MK et al (2000) Ethical decision making and patient autonomy: a comparison of physicians and patients in Japan and the United States. Chest 118:1172–1182PubMedCrossRef Ruhnke GW, Wilson SR, Akamatsu T, Kinoue T, Takashima Y, Goldstein MK et al (2000) Ethical decision making and patient autonomy: a comparison of physicians and patients in Japan and the United States. Chest 118:1172–1182PubMedCrossRef
23.
Zurück zum Zitat Morita T, Hyodo I, Yoshimi T, Ikenaga M, Tamura Y, Yoshizawa A et al (2005) Association between hydration volume and symptoms in terminally ill cancer patients with abdominal malignancies. Ann Oncol 16:640–647PubMedCrossRef Morita T, Hyodo I, Yoshimi T, Ikenaga M, Tamura Y, Yoshizawa A et al (2005) Association between hydration volume and symptoms in terminally ill cancer patients with abdominal malignancies. Ann Oncol 16:640–647PubMedCrossRef
24.
Zurück zum Zitat Yamagishi A, Morita T, Miyashita M, Akizuki N, Kizawa Y, Shirahige Y et al (2008) Palliative care in Japan: current status and a nationwide challenge to improve palliative care by the Cancer Control Act and the Outreach Palliative Care Trial of Integrated Regional Model (OPTIM) study. Am J Hosp Palliat Care 25:412–418PubMed Yamagishi A, Morita T, Miyashita M, Akizuki N, Kizawa Y, Shirahige Y et al (2008) Palliative care in Japan: current status and a nationwide challenge to improve palliative care by the Cancer Control Act and the Outreach Palliative Care Trial of Integrated Regional Model (OPTIM) study. Am J Hosp Palliat Care 25:412–418PubMed
Metadaten
Titel
Quality of end-of-life care for patients with metastatic non-small-cell lung cancer in general wards and palliative care units in Japan
verfasst von
Kikuo Nakano
Takashi Yoshida
Junko Furutama
Shoji Sunada
Publikationsdatum
01.04.2012
Verlag
Springer-Verlag
Erschienen in
Supportive Care in Cancer / Ausgabe 4/2012
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-011-1374-7

Weitere Artikel der Ausgabe 4/2012

Supportive Care in Cancer 4/2012 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.