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01.11.2013 | Review Article

Systematic review of natural agents for the management of oral mucositis in cancer patients

verfasst von: Noam Yarom, Anura Ariyawardana, Allan Hovan, Andrei Barasch, Virginia Jarvis, Siri Beier Jensen, Yehuda Zadik, Sharon Elad, Joanne Bowen, Rajesh V. Lalla, For the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO)

Erschienen in: Supportive Care in Cancer | Ausgabe 11/2013

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Abstract

Purpose

The aim of this study was to review the available literature and define clinical practice guidelines for the use of natural agents for the prevention and treatment of oral mucositis.

Methods

A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology. The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. Based on the evidence level, one of the following three guideline determinations was possible: recommendation, suggestion, and no guideline possible.

Results

A total of 49 papers across 15 interventions were examined. A new suggestion was developed in favor of systemic zinc supplements administered orally in the prevention of oral mucositis in oral cancer patients receiving radiation therapy or chemoradiation (Level III evidence). A recommendation was made against the use of intravenous glutamine for the prevention of oral mucositis in patients receiving high-dose chemotherapy prior to hematopoietic stem cell transplant (Level II evidence). No guideline was possible for any other agent, due to inadequate and/or conflicting evidence.

Conclusions

Of the various natural agents reviewed here, the available evidence supported a guideline only for two agents: a suggestion in favor of zinc and a recommendation against glutamine, in the treatment settings listed above. Well-designed studies of other natural agents are warranted.

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Titel: Systematic review of natural agents for the management of oral mucositis in cancer patients
verfasst von: Noam Yarom
Anura Ariyawardana
Allan Hovan
Andrei Barasch
Virginia Jarvis
Siri Beier Jensen
Yehuda Zadik
Sharon Elad
Joanne Bowen
Rajesh V. Lalla
For the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO)
Publikationsdatum: 01.11.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 11/2013
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-013-1869-5

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Systematic review of natural agents for the management of oral mucositis in cancer patients

Abstract

Purpose

Methods

Results

Conclusions

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