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Erschienen in: Supportive Care in Cancer 8/2015

01.08.2015 | Original Article

Geriatric assessment as an aide to understanding falls in older adults with cancer

verfasst von: Grant R. Williams, Allison M. Deal, Kirsten A. Nyrop, Mackenzi Pergolotti, Emily J. Guerard, Trevor A. Jolly, Hyman B. Muss

Erschienen in: Supportive Care in Cancer | Ausgabe 8/2015

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Abstract

Purpose

In older adults, falls are a common cause of functional decline, institutionalization, and reduced quality of life. This study (1) investigates the prevalence of falls in a large sample of community-dwelling older adults with a cancer diagnosis and (2) evaluates the association of falls with domains of comprehensive geriatric assessment (CGA) that pertain to falls risk.

Methods

Patients completed a CGA that includes a self-reported measure of number of falls in the past 6 months. Summary statistics are used to describe prevalence of falls and associations with hypothesized risk factors using Fisher’s exact tests and multivariable logistic regression.

Results

A total of 1172 patients were enrolled, mean age 73 (65–99), 74 % female, and 89 % Caucasian. Two hundred fifty-six (22 %) reported one or more falls within the last 6 months. Patients with at least one instrumental activities of daily living (IADL) or physical function deficit had more falls as compared those with no deficits identified (p ≤ 0.001). The number of daily medications, comorbidities, Timed Up and Go score >14 s, and poor vision were also associated with increased falls (p ≤ 0.001). Reduced physical function, poor vision, and low performance status had the highest adjusted odds ratio (3.6, 3.4, and 3.0, respectively) for falls.

Conclusions

There is a high prevalence of falls in community-dwelling older patients with a cancer diagnosis. Falls are significantly associated with several measures of geriatric assessment including IADL, physical function, comorbidities, medications, and vision. Timely identification and management of risk factors for falls are important considerations in the care of older cancer patients.
Literatur
1.
Zurück zum Zitat Blake AJ, Morgan K, Bendall MJ, Dallosso H, Ebrahim S, Arie TH, Fentem PH, Bassey EJ (1988) Falls by elderly people at home: prevalence and associated factors. Age Ageing 17(6):365–372PubMedCrossRef Blake AJ, Morgan K, Bendall MJ, Dallosso H, Ebrahim S, Arie TH, Fentem PH, Bassey EJ (1988) Falls by elderly people at home: prevalence and associated factors. Age Ageing 17(6):365–372PubMedCrossRef
2.
Zurück zum Zitat Tromp AM, Pluijm SM, Smit JH, Deeg DJ, Bouter LM, Lips P (2001) Fall-risk screening test: a prospective study on predictors for falls in community-dwelling elderly. J Clin Epidemiol 54(8):837–844PubMedCrossRef Tromp AM, Pluijm SM, Smit JH, Deeg DJ, Bouter LM, Lips P (2001) Fall-risk screening test: a prospective study on predictors for falls in community-dwelling elderly. J Clin Epidemiol 54(8):837–844PubMedCrossRef
6.
Zurück zum Zitat Vellas BJ, Wayne SJ, Romero LJ, Baumgartner RN, Garry PJ (1997) Fear of falling and restriction of mobility in elderly fallers. Age Ageing 26(3):189–193PubMedCrossRef Vellas BJ, Wayne SJ, Romero LJ, Baumgartner RN, Garry PJ (1997) Fear of falling and restriction of mobility in elderly fallers. Age Ageing 26(3):189–193PubMedCrossRef
9.
Zurück zum Zitat Mohile SG, Fan L, Reeve E, Jean-Pierre P, Mustian K et al (2011) Association of cancer with geriatric syndromes in older Medicare beneficiaries. J Clin Oncol : Off J Am Soc Clin Oncol 29(11):1458–1464CrossRef Mohile SG, Fan L, Reeve E, Jean-Pierre P, Mustian K et al (2011) Association of cancer with geriatric syndromes in older Medicare beneficiaries. J Clin Oncol : Off J Am Soc Clin Oncol 29(11):1458–1464CrossRef
10.
Zurück zum Zitat Spoelstra SL, Given BA, Schutte DL, Sikorskii A, You M, Given CW (2013) Do older adults with cancer fall more often? A comparative analysis of falls in those with and without cancer. Oncol Nurs Forum 40(2):E69–78. doi:10.1188/13.ONF. E69-E78 PubMedCrossRef Spoelstra SL, Given BA, Schutte DL, Sikorskii A, You M, Given CW (2013) Do older adults with cancer fall more often? A comparative analysis of falls in those with and without cancer. Oncol Nurs Forum 40(2):E69–78. doi:10.​1188/​13.​ONF.​ E69-E78 PubMedCrossRef
11.
Zurück zum Zitat Chen Z, Maricic M, Aragaki AK, Mouton C, Arendell L, Lopez AM, Bassford T, Chlebowski RT (2009) Fracture risk increases after diagnosis of breast or other cancers in postmenopausal women: results from the Women’s Health Initiative. Osteoporos Int : J Established Result Cooperation Between Eur Found Osteoporos Natl Osteoporos Found of the USA 20(4):527–536CrossRef Chen Z, Maricic M, Aragaki AK, Mouton C, Arendell L, Lopez AM, Bassford T, Chlebowski RT (2009) Fracture risk increases after diagnosis of breast or other cancers in postmenopausal women: results from the Women’s Health Initiative. Osteoporos Int : J Established Result Cooperation Between Eur Found Osteoporos Natl Osteoporos Found of the USA 20(4):527–536CrossRef
12.
Zurück zum Zitat Hirbe A, Morgan EA, Uluçkan O, Weilbaecher K (2006) Skeletal complications of breast cancer therapies. Clin Cancer Res : Off J Am Assoc Cancer Res 12(20 Pt 2):6309s–6314sCrossRef Hirbe A, Morgan EA, Uluçkan O, Weilbaecher K (2006) Skeletal complications of breast cancer therapies. Clin Cancer Res : Off J Am Assoc Cancer Res 12(20 Pt 2):6309s–6314sCrossRef
13.
Zurück zum Zitat Winters-Stone KM, Nail L, Bennett JA, Schwartz A (2009) Bone health and falls: fracture risk in breast cancer survivors with chemotherapy-induced amenorrhea. Oncol Nurs Forum 36(3):315–325PubMedCrossRef Winters-Stone KM, Nail L, Bennett JA, Schwartz A (2009) Bone health and falls: fracture risk in breast cancer survivors with chemotherapy-induced amenorrhea. Oncol Nurs Forum 36(3):315–325PubMedCrossRef
14.
Zurück zum Zitat Bylow K, Dale W, Mustian K, Wm S, Rodin M, Hall W, Lachs M, Mohile SG (2008) Falls and physical performance deficits in older patients with prostate cancer undergoing androgen deprivation therapy. Med Oncol 72:422–427 Bylow K, Dale W, Mustian K, Wm S, Rodin M, Hall W, Lachs M, Mohile SG (2008) Falls and physical performance deficits in older patients with prostate cancer undergoing androgen deprivation therapy. Med Oncol 72:422–427
15.
Zurück zum Zitat American Geriatrics Society, British Geriatrics Society (2010) AGS/BGS clinical practice guideline: prevention of falls in older persons. American Geriatrics Society, New York (NY) American Geriatrics Society, British Geriatrics Society (2010) AGS/BGS clinical practice guideline: prevention of falls in older persons. American Geriatrics Society, New York (NY)
16.
Zurück zum Zitat Hurria A, Gupta S, Zauderer M, Zuckerman EL, Cohen HJ et al (2005) Developing a cancer-specific geriatric assessment: a feasibility study. Cancer 104:1998–2005PubMedCrossRef Hurria A, Gupta S, Zauderer M, Zuckerman EL, Cohen HJ et al (2005) Developing a cancer-specific geriatric assessment: a feasibility study. Cancer 104:1998–2005PubMedCrossRef
17.
Zurück zum Zitat Hurria A, Cirricione CT, Muss HB, Kornblith AB, Barry W et al (2011) Implementing a geriatric assessment in cooperative group clinical cancer trials: CALGB 360401. J Clin Oncol : Off J Am Soc Clin Oncol 29(10):1290–1296CrossRef Hurria A, Cirricione CT, Muss HB, Kornblith AB, Barry W et al (2011) Implementing a geriatric assessment in cooperative group clinical cancer trials: CALGB 360401. J Clin Oncol : Off J Am Soc Clin Oncol 29(10):1290–1296CrossRef
18.
Zurück zum Zitat Hurria A, Lichtman SM, Gardes J, Li D, Limaye S et al (2007) Identifying vulnerable older adults with cancer: integrating geriatric assessment into oncology practice. J Am Geriatr Soc 55(10):1604–1608PubMedCrossRef Hurria A, Lichtman SM, Gardes J, Li D, Limaye S et al (2007) Identifying vulnerable older adults with cancer: integrating geriatric assessment into oncology practice. J Am Geriatr Soc 55(10):1604–1608PubMedCrossRef
19.
20.
Zurück zum Zitat Podsiadlo D, Richardson S (1991) The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 39(2):142–148PubMedCrossRef Podsiadlo D, Richardson S (1991) The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 39(2):142–148PubMedCrossRef
21.
Zurück zum Zitat Karnofsky D, Burchenal J (1948) The clinical evaluation of chemotherapeutic agents in cancer. In: Macleod CM (ed) Evaluation of chemotherapeutic agents. In. Columbia University Press, New York, NY, pp 191-205 Karnofsky D, Burchenal J (1948) The clinical evaluation of chemotherapeutic agents in cancer. In: Macleod CM (ed) Evaluation of chemotherapeutic agents. In. Columbia University Press, New York, NY, pp 191-205
22.
Zurück zum Zitat Katzman R, Brown T, Fuld P, Peck A, Schechter R, Schimmel H (1983) Validation of a short Orientation-Memory-Concentration Test of cognitive impairment. Am J Psychiat 140(6):734–739PubMedCrossRef Katzman R, Brown T, Fuld P, Peck A, Schechter R, Schimmel H (1983) Validation of a short Orientation-Memory-Concentration Test of cognitive impairment. Am J Psychiat 140(6):734–739PubMedCrossRef
23.
Zurück zum Zitat Landi F, Onder G, Gambassi G, Pedone C, Carbonin PU, Bernabei R (2000) Body mass index mortality among hospitalized patients. Arch Intern Med 160:2641–2644PubMedCrossRef Landi F, Onder G, Gambassi G, Pedone C, Carbonin PU, Bernabei R (2000) Body mass index mortality among hospitalized patients. Arch Intern Med 160:2641–2644PubMedCrossRef
24.
Zurück zum Zitat Fillenbaum GG, Smyer MA (1981) The development, validity, and reliability of the OARS Multidimensional Functional Assessment Questionnaire. J Gerontol 36(4):428–434PubMedCrossRef Fillenbaum GG, Smyer MA (1981) The development, validity, and reliability of the OARS Multidimensional Functional Assessment Questionnaire. J Gerontol 36(4):428–434PubMedCrossRef
25.
Zurück zum Zitat Stewart AL, Kamberg CJ (1991) Physical functioning measures. In: Stewart AL, Ware JE Jr (eds) Measuring functioning and well-being: the medical outcomes survey. Duke University Press, Durham Stewart AL, Kamberg CJ (1991) Physical functioning measures. In: Stewart AL, Ware JE Jr (eds) Measuring functioning and well-being: the medical outcomes survey. Duke University Press, Durham
26.
Zurück zum Zitat Loprinzi CL, Laurie JA, Wieand HS, Krook JE, Novotny PJ, Kugler JM, Bartel J, Law M, Bateman M, Klatte NE et al (1994) Prospective evaluation of prognostic variables from patient-completed questionnaires. North Central Cancer Treatment Group. J Clin Oncol : Off J Am Soc Clin Oncol 12(3):601–607 Loprinzi CL, Laurie JA, Wieand HS, Krook JE, Novotny PJ, Kugler JM, Bartel J, Law M, Bateman M, Klatte NE et al (1994) Prospective evaluation of prognostic variables from patient-completed questionnaires. North Central Cancer Treatment Group. J Clin Oncol : Off J Am Soc Clin Oncol 12(3):601–607
29.
Zurück zum Zitat Lees J, Chan A (2011) Polypharmacy in elderly patients with cancer: clinical implications and management. Lancet Oncol 12(13):1249–1257PubMedCrossRef Lees J, Chan A (2011) Polypharmacy in elderly patients with cancer: clinical implications and management. Lancet Oncol 12(13):1249–1257PubMedCrossRef
30.
Zurück zum Zitat Extermann M, Overcash J, Lyman GH, Parr J, Balducci L (1998) Comorbidity and functional status are independent in older cancer patients. J Clin Oncol : Off J Am Soc Clin Oncol 16(4):1582–1587 Extermann M, Overcash J, Lyman GH, Parr J, Balducci L (1998) Comorbidity and functional status are independent in older cancer patients. J Clin Oncol : Off J Am Soc Clin Oncol 16(4):1582–1587
31.
Zurück zum Zitat Newman AB, Yanez D, Harris T, Duxbury A, Enright PL et al (2001) Weight change in old age and its association with mortality. J Am Geriatr Soc 49(10):1309–1318PubMedCrossRef Newman AB, Yanez D, Harris T, Duxbury A, Enright PL et al (2001) Weight change in old age and its association with mortality. J Am Geriatr Soc 49(10):1309–1318PubMedCrossRef
32.
Zurück zum Zitat Kelly MJ, Dunstan FD, Lloyd K, Fone DL (2008) Evaluating cutpoints for the MHI-5 and MCS using the CGQ-12: a comparison of five different methods. BMC Psychiatry 8(10):1–9 Kelly MJ, Dunstan FD, Lloyd K, Fone DL (2008) Evaluating cutpoints for the MHI-5 and MCS using the CGQ-12: a comparison of five different methods. BMC Psychiatry 8(10):1–9
34.
Zurück zum Zitat Gillespie LD, Robertson MC, Gillespie WJ, Sherrington C, Gates S, Clemson LM, Lamb SE (2012) Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev (9). doi:10.1002/14651858.CD007146.pub3 Gillespie LD, Robertson MC, Gillespie WJ, Sherrington C, Gates S, Clemson LM, Lamb SE (2012) Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev (9). doi:10.​1002/​14651858.​CD007146.​pub3
35.
Zurück zum Zitat Michael YL, Whitlock EP, Lin JS, Fu RW, O’Connor EA, Gold R (2010) Primary care-relevant interventions to prevent falling in older adults: a systematic evidence review for the U.S. Preventive Services Task Force. Ann Intern Med 153(12):815-+PubMedCrossRef Michael YL, Whitlock EP, Lin JS, Fu RW, O’Connor EA, Gold R (2010) Primary care-relevant interventions to prevent falling in older adults: a systematic evidence review for the U.S. Preventive Services Task Force. Ann Intern Med 153(12):815-+PubMedCrossRef
37.
Zurück zum Zitat Stubblefield MD Cancer rehabilitation (2011) In: Semin Oncol, 2011. vol 3. Elsevier, pp 386-393 Stubblefield MD Cancer rehabilitation (2011) In: Semin Oncol, 2011. vol 3. Elsevier, pp 386-393
39.
Zurück zum Zitat Clark F, Azen SP, Zemke R, Jackson J, Carlson M, Mandel D, Hay J, Josephson K, Cherry B, Hessel C (1997) Occupational therapy for independent-living older adults: a randomized controlled trial. JAMA : J Am Med Assoc 278(16):1321–1326CrossRef Clark F, Azen SP, Zemke R, Jackson J, Carlson M, Mandel D, Hay J, Josephson K, Cherry B, Hessel C (1997) Occupational therapy for independent-living older adults: a randomized controlled trial. JAMA : J Am Med Assoc 278(16):1321–1326CrossRef
40.
Zurück zum Zitat Cumming RG, Thomas M, Szonyi G, Salkeld G, O’Neill E, Westbury C, Frampton G (1999) Home visits by an occupational therapist for assessment and modification of environmental hazards: a randomized trial of falls prevention. J Am Geriatr Soc 47(12):1397–1402PubMedCrossRef Cumming RG, Thomas M, Szonyi G, Salkeld G, O’Neill E, Westbury C, Frampton G (1999) Home visits by an occupational therapist for assessment and modification of environmental hazards: a randomized trial of falls prevention. J Am Geriatr Soc 47(12):1397–1402PubMedCrossRef
41.
Zurück zum Zitat Barbour KE, Helmick CG, Theis KA, Murphy LB, Hootman JM, Brady TJ (2013) Prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation—United States, 2010–2012. MMWR 62(44):869–873 Barbour KE, Helmick CG, Theis KA, Murphy LB, Hootman JM, Brady TJ (2013) Prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation—United States, 2010–2012. MMWR 62(44):869–873
42.
Zurück zum Zitat Mayo NE, Wood-Dauphinee S, Côté R, Durcan L, Carlton J (2002) Activity, participation, and quality of life 6 months poststroke. Arch Phys Med Rehabil 83(8):1035–1042PubMedCrossRef Mayo NE, Wood-Dauphinee S, Côté R, Durcan L, Carlton J (2002) Activity, participation, and quality of life 6 months poststroke. Arch Phys Med Rehabil 83(8):1035–1042PubMedCrossRef
43.
Zurück zum Zitat Stone CA, Lawlor PG, Savva GM, Bennett K, Kenny RA (2012) Prospective study of falls and risk factors for falls in adults with advanced cancer. J Clin Oncol : Off J Am Soc Clin Oncol 30(17):2128–2133. doi:10.1200/JCO.2011.40.7791 CrossRef Stone CA, Lawlor PG, Savva GM, Bennett K, Kenny RA (2012) Prospective study of falls and risk factors for falls in adults with advanced cancer. J Clin Oncol : Off J Am Soc Clin Oncol 30(17):2128–2133. doi:10.​1200/​JCO.​2011.​40.​7791 CrossRef
44.
Zurück zum Zitat Perell KL, Nelson A, Goldman RL, Luther SL, Prieto-Lewis N, Rubenstein LZ (2001) Fall risk assessment measures: an analytic review. J Gerontol Med Sci 56(12):M761–M766CrossRef Perell KL, Nelson A, Goldman RL, Luther SL, Prieto-Lewis N, Rubenstein LZ (2001) Fall risk assessment measures: an analytic review. J Gerontol Med Sci 56(12):M761–M766CrossRef
45.
Zurück zum Zitat Fick DM, Cooper JW, Wade WE, Walter LJ, Maclean JR, Beers MH (2003) Updating the Beers Criteria for potentially inappropriate medication use in older adults: results of a U.S. consensus panel of experts. Arch Intern Med 163:2716–2724PubMedCrossRef Fick DM, Cooper JW, Wade WE, Walter LJ, Maclean JR, Beers MH (2003) Updating the Beers Criteria for potentially inappropriate medication use in older adults: results of a U.S. consensus panel of experts. Arch Intern Med 163:2716–2724PubMedCrossRef
Metadaten
Titel
Geriatric assessment as an aide to understanding falls in older adults with cancer
verfasst von
Grant R. Williams
Allison M. Deal
Kirsten A. Nyrop
Mackenzi Pergolotti
Emily J. Guerard
Trevor A. Jolly
Hyman B. Muss
Publikationsdatum
01.08.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Supportive Care in Cancer / Ausgabe 8/2015
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-014-2598-0

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