Skip to main content
Erschienen in: Supportive Care in Cancer 7/2016

11.02.2016 | Original Article

Life and treatment goals of patients with advanced, incurable cancer

verfasst von: Kevin L. Rand, Daniella A. Banno, Amanda M. Shea, Larry D. Cripe

Erschienen in: Supportive Care in Cancer | Ausgabe 7/2016

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Goals of care conversations have been suggested as a strategy for helping patients with advanced cancer manage the uncertainty and distress associated with end-of-life care. However, knowledge deficits about patient goals limit the utility of such conversations. We described the life and treatment goals of patients with incurable cancers, including goal values and expectancies. We examined the associations between paramount goals and patient prognosis, performance status, and psychological adjustment.

Methods

Patients with advanced lung cancer, gastrointestinal cancer, or melanoma (N = 84) completed measures of prognosis for 12-month survival, hope, optimism, depression, and anxiety. Oncologists provided patient performance status and prognosis for 12-month survival. We conducted interviews with a subset of patients (N = 63), eliciting life and treatment goals, values, and expectancies.

Results

Patient life goals resembled goals among healthy populations; whereas, treatment goals were perceived as separate and more important. Cure and fight cancer emerged as the most important goals. Patients who valued cure the most had worse performance status (M = 1.46 vs. 0.78) and more depressive symptoms (M = 6.30 vs. 3.50). Patients who valued fight cancer the most had worse self-prognosis (M = 69.23 % vs. 86.11 %), fewer treatment goals (M = 2.08 vs. 3.16), and lower optimism (M = 15.00 vs. 18.32).

Conclusions

Patients with advanced cancer perceive treatment goals as separate from and more important than life goals. They hold optimistic expectancies for achieving their goals and for survival. Valuing cure highly may put patients at risk for experiencing psychological maladjustment.
Fußnoten
1
Although we could hypothesize that some goals were implicitly related to the patient’s cancer (e.g., “To live another 20 years”), we chose to only categorize goals that explicitly mentioned cancer or its treatment in order to minimize the influence of the investigator’s subjective judgment.
 
Literatur
1.
Zurück zum Zitat Steinhauser KE, Christakis NA, Clipp EC, McNeilly M, McIntyre L, Tulsky JA (2000) Factors considered important at the end of life by patients, family, physicians, and other care providers. JAMA 284:2476–82CrossRefPubMed Steinhauser KE, Christakis NA, Clipp EC, McNeilly M, McIntyre L, Tulsky JA (2000) Factors considered important at the end of life by patients, family, physicians, and other care providers. JAMA 284:2476–82CrossRefPubMed
2.
Zurück zum Zitat Wright AA, Zhang B, Ray A, Mack JW, Trice E et al (2008) Associations between end-of-life discussions, patient mental health, medical care near death, and caregiver bereavement adjustment. JAMA 300:1665–73CrossRefPubMedPubMedCentral Wright AA, Zhang B, Ray A, Mack JW, Trice E et al (2008) Associations between end-of-life discussions, patient mental health, medical care near death, and caregiver bereavement adjustment. JAMA 300:1665–73CrossRefPubMedPubMedCentral
3.
4.
Zurück zum Zitat Zimmermann C, Burman D, Swami N, Krzyzanowska MK, Leighl N et al (2011) Determinants of quality of life in patients with advanced cancer. Support Care Cancer Off J Multinational Assoc Support Care Cancer 19:621–9 Zimmermann C, Burman D, Swami N, Krzyzanowska MK, Leighl N et al (2011) Determinants of quality of life in patients with advanced cancer. Support Care Cancer Off J Multinational Assoc Support Care Cancer 19:621–9
6.
Zurück zum Zitat Voogt E, van der Heide A, Rietjens JAC, van Leeuwen AF, Visser AP et al (2005) Attitudes of patients with incurable cancer toward medical treatment in the last phase of life. J Clin Oncol Off J Am Soc Clin Oncol 23:2012–9CrossRef Voogt E, van der Heide A, Rietjens JAC, van Leeuwen AF, Visser AP et al (2005) Attitudes of patients with incurable cancer toward medical treatment in the last phase of life. J Clin Oncol Off J Am Soc Clin Oncol 23:2012–9CrossRef
7.
Zurück zum Zitat Bradley EH, Bogardus ST Jr, Tinetti ME, Inouye SK (1999) Goal-setting in clinical medicine. Soc Sci Med 49:267–78CrossRefPubMed Bradley EH, Bogardus ST Jr, Tinetti ME, Inouye SK (1999) Goal-setting in clinical medicine. Soc Sci Med 49:267–78CrossRefPubMed
8.
Zurück zum Zitat Fischer GS, Alpert HR, Stoeckle JD, Emanuel LL (1997) Can goals of care be used to predict intervention preferences in an advance directive? Arch Intern Med 157:801–7CrossRefPubMed Fischer GS, Alpert HR, Stoeckle JD, Emanuel LL (1997) Can goals of care be used to predict intervention preferences in an advance directive? Arch Intern Med 157:801–7CrossRefPubMed
9.
Zurück zum Zitat Billings JA, Bernacki R (2014) Strategic targeting of advance care planning interventions: the goldilocks phenomenon. JAMA Intern Med Billings JA, Bernacki R (2014) Strategic targeting of advance care planning interventions: the goldilocks phenomenon. JAMA Intern Med
10.
Zurück zum Zitat Von Roenn JH, von Gunten CF (2003) Setting goals to maintain hope. J Clin Oncol Off J Am Soc Clin Oncol 21:570–4CrossRef Von Roenn JH, von Gunten CF (2003) Setting goals to maintain hope. J Clin Oncol Off J Am Soc Clin Oncol 21:570–4CrossRef
11.
Zurück zum Zitat Nissim R, Rennie D, Fleming S, Hales S, Gagliese L, Rodin G (2012) Goals set in the land of the living/dying: a longitudinal study of patients living with advanced cancer. Death Stud 36:360–90CrossRefPubMed Nissim R, Rennie D, Fleming S, Hales S, Gagliese L, Rodin G (2012) Goals set in the land of the living/dying: a longitudinal study of patients living with advanced cancer. Death Stud 36:360–90CrossRefPubMed
12.
Zurück zum Zitat Burns CM, Broom DH, Smith WT, Dear K, Craft PS (2007) Fluctuating awareness of treatment goals among patients and their caregivers: a longitudinal study of a dynamic process. Support Care Cancer Off J Multinational Assoc Support Cancer 15:187–96CrossRef Burns CM, Broom DH, Smith WT, Dear K, Craft PS (2007) Fluctuating awareness of treatment goals among patients and their caregivers: a longitudinal study of a dynamic process. Support Care Cancer Off J Multinational Assoc Support Cancer 15:187–96CrossRef
13.
Zurück zum Zitat Quill T, Norton S, Shah M, Lam Y, Fridd C, Buckley M (2006) What is most important for you to achieve? An analysis of patient responses when receiving palliative care consultation. J Palliat Med 9:382–8CrossRefPubMed Quill T, Norton S, Shah M, Lam Y, Fridd C, Buckley M (2006) What is most important for you to achieve? An analysis of patient responses when receiving palliative care consultation. J Palliat Med 9:382–8CrossRefPubMed
14.
Zurück zum Zitat Carver CS, Scheier MF (1998) On the self-regulation of behavior. Cambridge University Press, New YorkCrossRef Carver CS, Scheier MF (1998) On the self-regulation of behavior. Cambridge University Press, New YorkCrossRef
15.
Zurück zum Zitat Cameron LD, Leventhal H (2003) Self-regulation, health, and illness: an overview. In: Cameron LD, Leventhal H (eds) The self-regulation of health and illness behaviour. Routledge, New York, pp 1–13 Cameron LD, Leventhal H (2003) Self-regulation, health, and illness: an overview. In: Cameron LD, Leventhal H (eds) The self-regulation of health and illness behaviour. Routledge, New York, pp 1–13
16.
Zurück zum Zitat Carver CS, Scheier MF (1982) Outcome expectancy, locus of attribution for expectancy, and self-directed attention as determinants of evaluations and performance. J Exp Soc Psychol 18:184–200CrossRef Carver CS, Scheier MF (1982) Outcome expectancy, locus of attribution for expectancy, and self-directed attention as determinants of evaluations and performance. J Exp Soc Psychol 18:184–200CrossRef
17.
Zurück zum Zitat Carver CS, Scheier MF (1994) Situational coping and coping dispositions in a stressful transaction. J Pers Soc Psychol 66:184–95CrossRefPubMed Carver CS, Scheier MF (1994) Situational coping and coping dispositions in a stressful transaction. J Pers Soc Psychol 66:184–95CrossRefPubMed
18.
Zurück zum Zitat Scheier MF, Bridges MW (1995) Person variables and health: personality predispositions and acute psychological states as shared determinants for disease. Psychosom Med 57:255–68CrossRefPubMed Scheier MF, Bridges MW (1995) Person variables and health: personality predispositions and acute psychological states as shared determinants for disease. Psychosom Med 57:255–68CrossRefPubMed
19.
Zurück zum Zitat Scheier MF, Carver CS (1987) Dispositional optimism and physical well-being: the influence of generalized outcome expectancies on health. J Personal 55:169–210CrossRef Scheier MF, Carver CS (1987) Dispositional optimism and physical well-being: the influence of generalized outcome expectancies on health. J Personal 55:169–210CrossRef
20.
Zurück zum Zitat Scheier MF, Matthews KA, Owens JF, Magovern GJ Sr, Lefebvre RC et al (1989) Dispositional optimism and recovery from coronary artery bypass surgery: the beneficial effects on physical and psychological well-being. J Pers Soc Psychol 57:1024–40CrossRefPubMed Scheier MF, Matthews KA, Owens JF, Magovern GJ Sr, Lefebvre RC et al (1989) Dispositional optimism and recovery from coronary artery bypass surgery: the beneficial effects on physical and psychological well-being. J Pers Soc Psychol 57:1024–40CrossRefPubMed
21.
Zurück zum Zitat Austin JT, Vancouver JB (1996) Goal constructs in psychology: structure, process, and content. Psychol Bull 120:338–75CrossRef Austin JT, Vancouver JB (1996) Goal constructs in psychology: structure, process, and content. Psychol Bull 120:338–75CrossRef
22.
Zurück zum Zitat Trinkaus M, Burman D, Barmala N, Rodin G, Jones J et al (2011) Spirituality and use of complementary therapies for cure in advanced cancer. Psychooncology 20:746–54CrossRefPubMed Trinkaus M, Burman D, Barmala N, Rodin G, Jones J et al (2011) Spirituality and use of complementary therapies for cure in advanced cancer. Psychooncology 20:746–54CrossRefPubMed
23.
Zurück zum Zitat 2012 Adults with advanced cancer still hope for cure. BMJ (Clin Res Ed) 345:e7272–e 2012 Adults with advanced cancer still hope for cure. BMJ (Clin Res Ed) 345:e7272–e
24.
Zurück zum Zitat Cunningham D, Starling N, Rao S, Iveson T, Nicolson M et al (2008) Capecitabine and oxaliplatin for advanced esophagogastric cancer. N Engl J Med 358:36–46CrossRefPubMed Cunningham D, Starling N, Rao S, Iveson T, Nicolson M et al (2008) Capecitabine and oxaliplatin for advanced esophagogastric cancer. N Engl J Med 358:36–46CrossRefPubMed
25.
Zurück zum Zitat Moore MJ, Goldstein D, Hamm J, Figer A, Hecht JR et al (2007) Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol Off J Am Soc Clin Oncol 25:1960–6CrossRef Moore MJ, Goldstein D, Hamm J, Figer A, Hecht JR et al (2007) Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol Off J Am Soc Clin Oncol 25:1960–6CrossRef
26.
Zurück zum Zitat Hochster HS, Hart LL, Ramanathan RK, Childs BH, Hainsworth JD et al (2008) Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: results of the TREE Study. J Clin Oncol Off J Am Soc Clin Oncol 26:3523–9CrossRef Hochster HS, Hart LL, Ramanathan RK, Childs BH, Hainsworth JD et al (2008) Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: results of the TREE Study. J Clin Oncol Off J Am Soc Clin Oncol 26:3523–9CrossRef
27.
Zurück zum Zitat Tournigand C, Andre T, Achille E, Lledo G, Flesh M et al (2004) FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol Off J Am Soc Clin Oncol 22:229–37CrossRef Tournigand C, Andre T, Achille E, Lledo G, Flesh M et al (2004) FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol Off J Am Soc Clin Oncol 22:229–37CrossRef
28.
Zurück zum Zitat Sobrero AF, Maurel J, Fehrenbacher L, Scheithauer W, Abubakr YA et al (2008) EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J Clin Oncol Off J Am Soc Clin Oncol 26:2311–9CrossRef Sobrero AF, Maurel J, Fehrenbacher L, Scheithauer W, Abubakr YA et al (2008) EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J Clin Oncol Off J Am Soc Clin Oncol 26:2311–9CrossRef
29.
Zurück zum Zitat Schiller JH, Harrington D, Belani CP, Langer C, Sandler A et al (2002) Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 346:92–8CrossRefPubMed Schiller JH, Harrington D, Belani CP, Langer C, Sandler A et al (2002) Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 346:92–8CrossRefPubMed
30.
Zurück zum Zitat Kaldjian LC, Curtis AE, Shinkunas LA, Cannon KT (2009) Goals of care toward the end of life: a structured literature review. Am J Hosp Palliat Med 25:501–11CrossRef Kaldjian LC, Curtis AE, Shinkunas LA, Cannon KT (2009) Goals of care toward the end of life: a structured literature review. Am J Hosp Palliat Med 25:501–11CrossRef
31.
Zurück zum Zitat Snyder CR, Harris C, Anderson JR, Holleran SA, Irving LM et al (1991) The will and the ways: development and validation of an individual-differences measure of hope. J Pers Soc Psychol 60:570–85CrossRefPubMed Snyder CR, Harris C, Anderson JR, Holleran SA, Irving LM et al (1991) The will and the ways: development and validation of an individual-differences measure of hope. J Pers Soc Psychol 60:570–85CrossRefPubMed
32.
Zurück zum Zitat Scheier MF, Carver CS, Bridges MW (1994) Distinguishing optimism from neuroticism (and trait anxiety, self-mastery, and self-esteem): a reevaluation of the life orientation test. J Pers Soc Psychol 67:1063–78CrossRefPubMed Scheier MF, Carver CS, Bridges MW (1994) Distinguishing optimism from neuroticism (and trait anxiety, self-mastery, and self-esteem): a reevaluation of the life orientation test. J Pers Soc Psychol 67:1063–78CrossRefPubMed
33.
Zurück zum Zitat Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67:361–70CrossRefPubMed Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67:361–70CrossRefPubMed
34.
Zurück zum Zitat Smith AB, Selby PJ, Velikova G, Stark D, Wright EP et al (2002) Factor analysis of the Hospital Anxiety and Depression Scale from a large cancer population. Psychol Psychother Theory Res Pract 75:165–76CrossRef Smith AB, Selby PJ, Velikova G, Stark D, Wright EP et al (2002) Factor analysis of the Hospital Anxiety and Depression Scale from a large cancer population. Psychol Psychother Theory Res Pract 75:165–76CrossRef
35.
Zurück zum Zitat Cripe LD, Rawl SM, Schmidt KK, Tong Y, Monahan PO, Rand KL (2012) Discussions of life expectancy moderate relationships between prognosis and anxiety or depression in men with advanced cancer. J Palliat Med 15:99–105CrossRefPubMed Cripe LD, Rawl SM, Schmidt KK, Tong Y, Monahan PO, Rand KL (2012) Discussions of life expectancy moderate relationships between prognosis and anxiety or depression in men with advanced cancer. J Palliat Med 15:99–105CrossRefPubMed
36.
Zurück zum Zitat Bjelland I, Dahl AA, Haug TT, Neckelmann D (2002) The validity of the Hospital Anxiety and Depression Scale: an updated literature review. J Psychosom Res 52:69–77CrossRefPubMed Bjelland I, Dahl AA, Haug TT, Neckelmann D (2002) The validity of the Hospital Anxiety and Depression Scale: an updated literature review. J Psychosom Res 52:69–77CrossRefPubMed
37.
Zurück zum Zitat Pinquart M, Fröhlich C, Silbereisen RK (2008) Testing models of change in life goals after a cancer diagnosis. J Loss Trauma 13:330–51CrossRef Pinquart M, Fröhlich C, Silbereisen RK (2008) Testing models of change in life goals after a cancer diagnosis. J Loss Trauma 13:330–51CrossRef
38.
Zurück zum Zitat El-Jawahri A, Traeger L, Park ER, Greer JA, Pirl WF et al (2014) Associations among prognostic understanding, quality of life, and mood in patients with advanced cancer. Cancer 120:278–85CrossRefPubMed El-Jawahri A, Traeger L, Park ER, Greer JA, Pirl WF et al (2014) Associations among prognostic understanding, quality of life, and mood in patients with advanced cancer. Cancer 120:278–85CrossRefPubMed
39.
Zurück zum Zitat Weeks JC, Catalano PJ, Cronin A, Finkelman MD, Mack JW et al (2012) Patients’ expectations about effects of chemotherapy for advanced cancer. N Engl J Med 367:1616–25CrossRefPubMedPubMedCentral Weeks JC, Catalano PJ, Cronin A, Finkelman MD, Mack JW et al (2012) Patients’ expectations about effects of chemotherapy for advanced cancer. N Engl J Med 367:1616–25CrossRefPubMedPubMedCentral
40.
Zurück zum Zitat Taylor SE, Brown JD (1988) Illusion and well-being: a social psychological perspective on mental health. Psychol Bull 103:193–210CrossRefPubMed Taylor SE, Brown JD (1988) Illusion and well-being: a social psychological perspective on mental health. Psychol Bull 103:193–210CrossRefPubMed
41.
Zurück zum Zitat Chochinov HM, Tataryn DJ, Wilson KG, Enns M, Lander S (2000) Prognostic awareness and the terminally ill. Psychosom J Consult Liaison Psychiatry 41:500–4 Chochinov HM, Tataryn DJ, Wilson KG, Enns M, Lander S (2000) Prognostic awareness and the terminally ill. Psychosom J Consult Liaison Psychiatry 41:500–4
42.
Zurück zum Zitat Stadler G, Oettingen G, Gollwitzer PM (2010) Intervention effects of information and self-regulation on eating fruits and vegetables over two years. Health Psychol 29:274–83CrossRefPubMed Stadler G, Oettingen G, Gollwitzer PM (2010) Intervention effects of information and self-regulation on eating fruits and vegetables over two years. Health Psychol 29:274–83CrossRefPubMed
Metadaten
Titel
Life and treatment goals of patients with advanced, incurable cancer
verfasst von
Kevin L. Rand
Daniella A. Banno
Amanda M. Shea
Larry D. Cripe
Publikationsdatum
11.02.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Supportive Care in Cancer / Ausgabe 7/2016
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-016-3113-6

Weitere Artikel der Ausgabe 7/2016

Supportive Care in Cancer 7/2016 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.