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Erschienen in: Supportive Care in Cancer 9/2016

28.04.2016 | Original Article

Relationship between weight loss and parameters of skeletal muscle function in patients with advanced cancer and fatigue

verfasst von: P. Cresta Morgado, A. Giorlando, M. Castro, A. Navigante

Erschienen in: Supportive Care in Cancer | Ausgabe 9/2016

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Abstract

Purpose

This study aims to determine the influence of significant weight loss on parameters of skeletal muscle function in a population of advanced cancer patients with fatigue.

Methods

A cross-sectional and comparative study was designed between two arms of advanced cancer patients with fatigue (fatigue numeral scale (FNS) ≥4). A arm (n = 27) with ≥5 % weight loss in the last 6 months, and B arm (n = 22) without weight loss. Muscle strength was examined by hand grip technique and measurements of body composition by bioimpedance analysis (BIA), values of hemoglobin, albumin, lactic dehydrogenase (LDH), c-reactive protein (CRP), urine creatinine, and FNS. These variables were compared between both groups and correlated within each group.

Results

here were no differences concerning parameters of muscle strength between both arms. A arm had values of CRP ≥10 ug/dl in 77 % compared with 38.5 % of B arm (p = 0.004). A arm showed a higher percentage of body cell mass (%BCM) than B arm (p = 0.005). The A arm also showed a lower percentage of fat mass (%FM) (p = 0.014) when compared to the B arm. FNS was higher in A arm (median 7 vs 5; p = 0.047). All the variables of muscle strength had a significant positive correlation. In A arm, BCM had a negative significant correlation with CRP (p = 0.021).

Conclusions

In this study, significant weight loss and high CRP did not have influence on parameters of skeletal muscular function. We consider that further studies should be necessary, preferably with longitudinal designs to evaluate these findings.
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Metadaten
Titel
Relationship between weight loss and parameters of skeletal muscle function in patients with advanced cancer and fatigue
verfasst von
P. Cresta Morgado
A. Giorlando
M. Castro
A. Navigante
Publikationsdatum
28.04.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Supportive Care in Cancer / Ausgabe 9/2016
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-016-3236-9

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