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Supportive Care in Cancer

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28.01.2017 | Original Article

Effects of compensatory cognitive training intervention for breast cancer patients undergoing chemotherapy: a pilot study

verfasst von: Jin-Hee Park, Yong Sik Jung, Ku Sang Kim, Sun Hyoung Bae

Erschienen in: Supportive Care in Cancer | Ausgabe 6/2017

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Abstract

Purpose

Numerous breast cancer patients experience cognitive changes during and after chemotherapy. Chemotherapy-related cognitive impairment can significantly affect quality of life. This pilot study attempted to determine the effects of a compensatory cognitive training on the objective and subjective cognitive functioning of breast cancer patients receiving adjuvant chemotherapy.

Methods

Fifty-four patients were assigned to either a compensatory cognitive training or waitlist condition. They were assessed at baseline (T1), the completion of the 12-week intervention (T2), and 6 months after intervention completion (T3). Outcomes were assessed using the standardized neuropsychological tests and the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog), version 3. Raw data were converted to T-scores based on baseline scores, and a repeated-measures ANCOVA, adjusting for age, intelligence, depression, and treatment, was used for analysis. The effect sizes for differences in means were calculated.

Results

The intervention group improved significantly over time compared to the waitlist group on objective cognitive function. Among ten individual neuropsychological measures, immediate memory, delayed memory, verbal fluency in category, and verbal fluency in letter showed significant group × time interaction. In subjective cognitive function, scores of the waitlist group significantly decrease over time on perceived cognitive impairments, in contrast to those of the intervention group.

Conclusion

The 12-week compensatory cognitive training significantly improved the objective and subjective cognitive functioning of breast cancer patients. Because this was a pilot study, further research using a larger sample and longer follow-up durations is necessary.

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Korean Breast Cancer Society. Breast cancer facts & figures 2014. 2015 [cited 2015 November 15]; Available from: http://www.kbcs.or.kr/journal/file/2014_pdf.

Debess J, Riis JO, Pedersen L, Ewertz M (2009) Cognitive function and quality of life after surgery for early breast cancer in North Jutland, Denmark. Acta Oncol 48:532–540. doi:10.1080/02841860802600755 CrossRefPubMed

Wefel JS, Lenzi R, Theriault R et al (2004) ‘Chemobrain’ in breast carcinoma?: a prologue. Cancer 101:466–475. doi:10.1002/cncr.20393 CrossRefPubMed

Jemal A, Siegel R, Ward E et al (2009) Cancer statistics 2009. CA Cancer J Clin 59:225–249. doi:10.3322/caac.20006 CrossRefPubMed

Ahles TA, Saykin AJ (2007) Candidate mechanisms for chemotherapy-induced cognitive changes. Nat Rev Cancer 7:192–201. doi:10.1038/nrc2073 CrossRefPubMedPubMedCentral

Janelsins MC, Kesler SR, Ahles TA, Morrow GR (2014) Prevalence, mechanisms, and management of cancer-related cognitive impairment. Int Rev Psychiatry 26:102–113. doi:10.3109/09540261.2013.864260 CrossRefPubMedPubMedCentral

Janelsins MC, Kohli S, Mohile SG et al (2011) An update on cancer- and chemotherapy-related cognitive dysfunction: current status. Semin Oncol 38:431–438. doi:10.1053/j.seminoncol.2011.03.014 CrossRefPubMedPubMedCentral

Jansen CE, Cooper BA, Dodd MJ, Miaskowski CA (2011) A prospective longitudinal study of chemotherapy-induced cognitive changes in breast cancer patients. Support Care Cancer 19:1647–1656. doi:10.1007/s00520-010-0997-4 CrossRefPubMed

Ouimet LA, Stewart A, Collins B, Schindler D, Bielajew C (2009) Measuring neuropsychological change following breast cancer treatment: an analysis of statistical models. J Clin Exp Neuropsycho 31:73–89. doi:10.1080/13803390801992725 CrossRef

10.

Park JH, Bae SH (2012) A meta-analysis of chemotherapy related cognitive impairment in patients with breast cancer. J Korean Acad Nurs 42:644–658. doi:10.4040/jkan.2012.42.5.644 CrossRefPubMed

11.

Reid-Arndt SA, Yee A, Perry MC, Hsieh C (2009) Cognitive and psychological factors associated with early posttreatment functional outcomes in breast cancer survivors. J Psychosoc Oncol 27:415–434. doi:10.1080/07347330903183117 CrossRefPubMedPubMedCentral

12.

Wefel JS, Schagen SB (2012) Chemotherapy-related cognitive dysfunction. Curr Neurol Neurosci Rep 12:267–275. doi:10.1007/s11910-012-0264-9 CrossRefPubMed

13.

Wefel JS, Saleeba AK, Buzdar AU, Meyers CA (2010) Acute and late onset cognitive dysfunction associated with chemotherapy in women with breast cancer. Cancer 116:3348–3356. doi:10.1002/cncr.25098 CrossRefPubMed

14.

Frank JS, Vance DE, Jukkala A, Meneses KM (2014) Attention and memory deficits in breast cancer survivors: implications for nursing practice and research. J Neurosci Nurs 46:274–284. doi:10.1097/JNN.0000000000000078 CrossRefPubMed

15.

Ercoli LM, Castellon SA, Hunter AM et al (2013) Assessment of the feasibility of a rehabilitation intervention program for breast cancer survivors with cognitive complaints. Brain Imaging Behav 7:543–553. doi:10.1007/s11682-013-9237-0 CrossRefPubMed

16.

Von Ah D, Habermann B, Carpenter JS, Schneider BL (2013) Impact of perceived cognitive impairment in breast cancer survivors. Eur J Oncol Nurs 17:236–241. doi:10.1016/j.ejon.2012.06.002 CrossRefPubMed

17.

Myers JS (2012) Chemotherapy-related cognitive impairment: the breast cancer experience. Oncol Nurs Forum 39:E31–E40. doi:10.1188/12.ONF.E31-E40 CrossRefPubMed

18.

Boykoff N, Moieni M, Subramanian SK (2009) Confronting chemobrain: an in-depth look at survivors' reports of impact on work, social networks, and health care response. J Cancer Surviv 3:223–232. doi:10.1007/s11764-009-0098-x CrossRefPubMedPubMedCentral

19.

Vance DE, Frank JS, Bail J et al (2017) Interventions for cognitive deficits in breast cancer survivors treated with chemotherapy. Cancer Nurs 40:E11–E27. doi:10.1097/NCC.0000000000000349

20.

Von Ah D, Jansen CE, Allen DH (2014) Evidence-based interventions for cancer- and treatment-related cognitive impairment.Clin J Oncol Nurs18S:17–25. doi:10.1188/14.CJON.S3.17-25

21.

Ferguson RJ, McDonald BC, Rocque MA et al (2012) Development of CBT for chemotherapy-related cognitive change: results of a waitlist control trial. Psychooncology 21:176–186. doi:10.1002/pon.1878

22.

Ferguson RJ, Ahles TA, Saykin AJ et al (2007) Cognitive-behavioral management of chemotherapy-related cognitive change. Psychooncology 16:772-777. doi:10.1002/pon.1133

23.

Kang Y, Na D (2003) Seoul Neuropsychological Screening Battery (SNSB). 2003. Human Brain Research & Consulting Company, Korea

24.

Yi H, Chin J, Lee BH et al (2007) Development and validation of Korean version of trail making test for elderly persons. Dement Neurocogn Disord 6:54–66

25.

Wechsler D (1997) WAIS-III administration and scoring manual. The Paychological Coporation, Texas

26.

Wagner L, Sweet J, Butt Z et al (2009) Measuring patient self-reported cognitive functions: development of the functional assessment of cancer therapy-cognitive function instrument. J Support Oncol 7:W32–W39

27.

Beck AT, Steer RA, Brown GK (1996) Manual for the Beck Depression Inventory-II. The Paychological Coporation, Texas

28.

Carey CL, Woods SP, Gonzalez R et al (2004) Predictive validity of global deficit scores in detecting neuropsychological impairment in HIV infection. J Clin Exp Neuropsychol 26: 307–319. doi:10.1080/13803390490510031

29.

Morris SB (2007) Estimating effect sizes from pretest-posttest-control group designs. Organ Res Methods 11:364–386. doi:10.1177/1094428106291059

30.

Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. Hillsdale, New Jersey

31.

Cherrier MM, Anderson K, David Det al (2013) A randomized trial of cognitive rehabilitation in cancer survivors. Life Sci 93:617–622. doi:10.1016/j.lfs.2013.08.011

32.

King S, Green HJ (2015) Psychological intervention for improving cognitive function in cancer survivors: a literature review and randomized controlled trial. Front Oncol 5:72. doi:10.3389/fonc.2015.00072

33.

Schuurs A, Green HJ (2013) A feasibility study of group cognitive rehabilitation for cancer survivors: enhancing cognitive function and quality of life. Psychoocology 22:1043–1049. doi:10.1002/pon.3102DOI

34.

Vecera SP, Rizzo M (2004) What are you looking at? Impaired 'social attention' following frontal-lobe damage. Neuropsychologia 42:1657–1665. doi:10.1016/j.neuropsychologia.2004.04.009

35.

McDougall GJ, Becker H, Acee TW et al (2011) Symptom management of affective and cognitive disturbance with a group of cancer survivors. Arch Psychiatric Nurs 25:24–35. doi:10.1016/j.apnu.2010.05.004

36.

Ercoli LM, Petersen L, Hunter AMet al (2015) Cognitive rehabilitation group intervention for breast cancer survivors: results of a randomized clinical trial. Psychooncology 24:1360-1367. doi:10.1002/pon.3769

37.

Kesler S, Hadi Hosseini SM, Heckler Cet al. (2013) Cognitive training for improving executive function in chemotherapy-treated breast cancer survivors. Clin Breast Cancer 13:299–306. doi:10.1016/j.clbc.2013.02.004

38.

Von Ah D, Carpenter JS, SaykinAet al (2012) Advanced cognitive training for breast cancer survivors: a randomized controlled trial. Breast Cancer Res Treat 135:799–809. doi:10.1007/s10549-012-2210-6

39.

Fisk JE, Sharp CA (2004) Age-related impairment in executive functioning: updating, inhibition, shifting, and access. J Clin Exp Neuropsychol 26:874–890. doi:10.1080/13803390490510680

40.

Jean-Pierre P, Johnson-Greene D, Burish TG (2014) Neuropsychological care and rehabilitation of cancer patients with chemobrain: strategies for evaluation and intervention development. Support Care Cancer 22:2251–2260. doi:10.1007/s00520-014-2162-y

Titel: Effects of compensatory cognitive training intervention for breast cancer patients undergoing chemotherapy: a pilot study
verfasst von: Jin-Hee Park
Yong Sik Jung
Ku Sang Kim
Sun Hyoung Bae
Publikationsdatum: 28.01.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 6/2017
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-017-3589-8

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Springer Medizin

Effects of compensatory cognitive training intervention for breast cancer patients undergoing chemotherapy: a pilot study

Abstract

Purpose

Methods

Results

Conclusion

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Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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