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28.04.2018 | Original Article

Factors associated with falls in older adults with cancer: a validated model from the Cancer and Aging Research Group

verfasst von: Tanya M. Wildes, Ronald J. Maggiore, William P. Tew, David Smith, Can-Lan Sun, Harvey Cohen, Supriya G. Mohile, Ajeet Gajra, Heidi D. Klepin, Cynthia Owusu, Cary P. Gross, Hyman Muss, Andrew Chapman, Stuart M. Lichtman, Vani Katheria, Arti Hurria, On behalf of the Cancer and Aging Research Group

Erschienen in: Supportive Care in Cancer | Ausgabe 10/2018

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Abstract

Background

Falls in older adults with cancer are common, yet factors associated with fall-risk are not well-defined and may differ from the general geriatric population. This study aims to develop and validate a model of factors associated with prior falls among older adults with cancer.

Methods

In this cross-sectional secondary analysis, two cohorts of patients aged ≥ 65 with cancer were examined to develop and validate a model of factors associated with falls in the prior 6 months. Potential independent variables, including demographic and laboratory data and a geriatric assessment (encompassing comorbidities, functional status, physical performance, medications, and psychosocial status), were identified. A multivariate model was developed in the derivation cohort using an exhaustive modeling approach. The model selected for validation offered a low Akaike Information Criteria value and included dichotomized variables for ease of clinical use. This model was then applied in the validation cohort.

Results

The development cohort (N = 498) had a mean age of 73 (range 65–91). Nearly one-fifth (18.2%) reported a fall in the prior 6 months. The selected model comprised nine variables involving functional status, objective physical performance, depression, medications, and renal function. The AUC of the model was 0.72 (95% confidence intervals 0.65–0.78). In the validation cohort (N = 250), the prevalence of prior falls was 23.6%. The AUC of the model in the validation cohort was 0.62 (95% confidence intervals 0.51–0.71).

Conclusion

In this study, we developed and validated a model of factors associated with prior falls in older adults with cancer. Future study is needed to examine the utility of such a model in prospectively predicting incident falls.

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Titel: Factors associated with falls in older adults with cancer: a validated model from the Cancer and Aging Research Group
verfasst von: Tanya M. Wildes
Ronald J. Maggiore
William P. Tew
David Smith
Can-Lan Sun
Harvey Cohen
Supriya G. Mohile
Ajeet Gajra
Heidi D. Klepin
Cynthia Owusu
Cary P. Gross
Hyman Muss
Andrew Chapman
Stuart M. Lichtman
Vani Katheria
Arti Hurria
On behalf of the Cancer and Aging Research Group
Publikationsdatum: 28.04.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 10/2018
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-018-4212-3

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Factors associated with falls in older adults with cancer: a validated model from the Cancer and Aging Research Group

Abstract

Background

Methods

Results

Conclusion

Neu im Fachgebiet Onkologie

Prostatakarzinom: EU initiiert neues Screeningkonzept

Blasenkarzinom – Biomarker statt Zytologie?

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Background

Methods

Results

Conclusion

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