Abstract
Small-cell carcinoma occasionally occurs in the gastrointestinal tract, with rare reports of it in the biliary system. When it does occur in the biliary system, it is mainly within the gallbladder, and those arising in the extrahepatic bile duct are extremely rare with only seven reported cases to date. A 62-year-old man with this unusual condition is documented. The patient was preoperatively diagnosed as having small-cell carcinoma on the basis of a biopsy specimen and was treated with multidisciplinary management, which consisted of preoperative chemotherapy, a curative resection, adjuvant chemotherapy, and radiation therapy. The patient died 23 months after the initial diagnosis (20 months after surgery). To the best of our knowledge, the survival time of this case was the longest among reported cases, and multidisciplinary management might contribute to a prolonged survival.
Similar content being viewed by others
References
Levenson TM Jr, Ihde DC, Matthews MJ, et al. Small-cell carcinoma presenting as an extrapulmonary neoplasm: sites of origin and response to chemotherapy. J Natl Cancer Inst. 1981;67:607–12.
Eriguchi N, Aoyagi S, Noritomi T, Imamura M, Sato S, Fujiki K, et al. Adeno-endocrine cell carcinoma of the gallbladder. J Hepatobiliary Pancreat Surg. 2000;7:97–101.
Nakamura Y, Tajiri T, Uchida E, Arima Y, Aimoto T, et al. Changes to levels of serum neuron-specific enolase in a patient with small-cell carcinoma of the pancreas. J Hepatobiliary Pancreat Surg. 2005;12:93–8.
Sugawara G, Yamaguchi A, Isogai M, Watanabe Y, Kaneoka Y, Suzuki M. Small cell neuroendocrine carcinoma of the ampulla of Vater with foci of squamous differentiation: a case report. J Hepatobiliary Pancreat Surg. 2004;11:56–60.
Suzuki S, Tanaka S, Hayashi T, Harada N, Suzuki M, Hanyu F, et al. Small-cell neuroendocrine carcinoma of the ampulla of Vater. J Hepatobiliary Pancreat Surg. 2006;13:450–3.
Sabanathan H, Hashimi H, Nicholson G, Edwards AS. Primary oat cell carcinoma of the common bile duct. J R Coll Surg Edinb. 1988;33:285–6.
van der Wal AC, Leeuwen DJ, Walfold N. Small cell neuroendocrine (oat cell) tumour of the common bile duct. Histopathology. 1990;16:398–400.
Nishihara K, Tsuneyoshi M, Niiyama H, Ichikawa H. Composite glandular-endocrine cell carcinoma of the extrahepatic bile duct: immunohistochemical study. Pathology. 1993;25:90–4.
Kim SH, Park YN, Yoon DS, Lee SJ, Yu JS, Noh TW. Composite neuroendocrine and adenocarcinoma of the common bile duct associated with clonorchis sinensis: a case report. Hepatogastroenterology. 2000;47:942–4.
Hazama K, Suzuki Y, Takahashi M, et al. Primary small-cell carcinoma of the common bile duct, in which surgical treatment was performed after neoadjuvant chemotherapy: report of case. Surg Today. 2003;33:870–2.
Kuraoka K, Taniyama K, Fujitaka T, et al. Small-cell carcinoma of the extrahepatic bile duct: case report and immunohistochemical analysis. Pathol Int. 2003;53:887–91.
Kaiho T, Tanaka T, Tsuchiya S, et al. A case of small-cell carcinoma of the common bile duct. Hepatogastroenterology. 2005;52:363–7.
Kim JH, Lee SH, Park J, Kim HY, Lee SI, Nam EM, et al. Extrapulmonary small-cell carcinoma: a single-institution experience. Jpn J Clin Oncol. 2004;34:250–4.
Lo Re G, Canzonieri V, Veronesi A, Dal Bo V, Barzan L, Zancanaro C, et al. Extrapulmonary small-cell carcinoma: a single-institution experience and review of the literature. Ann Oncol. 1994;5:909–13.
Ron IG, Wigler N, Ilie B, Chaitchik S. Small-cell carcinoma of the gallbladder: clinical course and response to chemotherapy. Tumori. 1992;78:207–10.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Okamura, Y., Maeda, A., Matsunaga, K. et al. Small-cell carcinoma in the common bile duct treated with multidisciplinary management. J Hepatobiliary Pancreat Surg 16, 575–578 (2009). https://doi.org/10.1007/s00534-009-0051-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00534-009-0051-4