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Erschienen in: Journal of Hepato-Biliary-Pancreatic Sciences 3/2010

01.05.2010 | Topics

Mucin-producing bile duct tumors: radiological–pathological correlation and diagnostic strategy

verfasst von: Jae Hoon Lim, Kee-Taek Jang

Erschienen in: Journal of Hepato-Biliary-Pancreatic Sciences | Ausgabe 3/2010

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Abstract

Mucin-producing bile duct tumors are characterized by intraductal papillary tumors producing large amounts of mucin. The tumor comprises macroscopically prominent intraductal papillary neoplastic epithelia and produces a large amount of viscid mucin, resulting in dilatation of the bile ducts. The surface of the tumor is frond-like, velvety, or serrated. The tumor exhibits five intraductal growth patterns; polypoid intraductal growth, mucosal spreading growth, cast-like intraductal growth, cystic tumor, and intraductal floating tumors. Imaging features reflect the interplay between the morphology of the tumor, the amount of mucin production, and biliary dilatation. This review article describes the radiological manifestations of the tumor, based on pathological-radiological correlation and biological behavior.
Literatur
1.
Zurück zum Zitat Nakanuma Y, Sasaki M, Ishikawa A, Tsui W, Chen TC, Huang SF. Biliary papillary neoplasm of the liver. Histol Histopathol. 2002;17:851–61.PubMed Nakanuma Y, Sasaki M, Ishikawa A, Tsui W, Chen TC, Huang SF. Biliary papillary neoplasm of the liver. Histol Histopathol. 2002;17:851–61.PubMed
2.
Zurück zum Zitat Zen Y, Fujii T, Itatsu K, et al. Biliary cystic tumors with bile duct communication: a cystic variant of intraductal papillary neoplasm of the bile duct. Mod Pathol. 2006;19:1243–54.CrossRefPubMed Zen Y, Fujii T, Itatsu K, et al. Biliary cystic tumors with bile duct communication: a cystic variant of intraductal papillary neoplasm of the bile duct. Mod Pathol. 2006;19:1243–54.CrossRefPubMed
3.
Zurück zum Zitat Lee SS, Kim MH, Lee SK, et al. Clinicopathologic review of 58 patients with biliary papillomatosis. Cancer. 2004;100:783–93.CrossRefPubMed Lee SS, Kim MH, Lee SK, et al. Clinicopathologic review of 58 patients with biliary papillomatosis. Cancer. 2004;100:783–93.CrossRefPubMed
4.
Zurück zum Zitat Kim YS, Myung SJ, Kim SY, et al. Biliary papillomatosis: clinical, cholangiographic and cholangioscopic findings. Endoscopy. 1998;30:763–7.CrossRefPubMed Kim YS, Myung SJ, Kim SY, et al. Biliary papillomatosis: clinical, cholangiographic and cholangioscopic findings. Endoscopy. 1998;30:763–7.CrossRefPubMed
5.
Zurück zum Zitat Holtkamp W, Reis HE. Papillomatosis of the bile ducts: papilloma–carcinoma sequence. Am J Gastroenterol. 1994;89:2253–5.PubMed Holtkamp W, Reis HE. Papillomatosis of the bile ducts: papilloma–carcinoma sequence. Am J Gastroenterol. 1994;89:2253–5.PubMed
6.
Zurück zum Zitat Suh KS, Roh HR, Koh YT, Lee KU, Park YH, Kim SW. Clinicopathological features of the intraductal growth type of peripheral cholangiocarcinoma. Hepatology. 2000;31:12–7.CrossRefPubMed Suh KS, Roh HR, Koh YT, Lee KU, Park YH, Kim SW. Clinicopathological features of the intraductal growth type of peripheral cholangiocarcinoma. Hepatology. 2000;31:12–7.CrossRefPubMed
7.
Zurück zum Zitat Lim JH, Yi CA, Lim HK, Lee WJ, Lee SJ, Kim SH. Radiological spectrum of intraductal papillary tumors of the bile ducts. Korean J Radiol. 2002;3:57–63.CrossRefPubMed Lim JH, Yi CA, Lim HK, Lee WJ, Lee SJ, Kim SH. Radiological spectrum of intraductal papillary tumors of the bile ducts. Korean J Radiol. 2002;3:57–63.CrossRefPubMed
8.
Zurück zum Zitat Lim JH, Kim YI, Park CK. Intraductal mucosal-spreading mucin-producing peripheral cholangiocarcinoma of the liver. Abdom Imaging. 2000;25:89–92.CrossRefPubMed Lim JH, Kim YI, Park CK. Intraductal mucosal-spreading mucin-producing peripheral cholangiocarcinoma of the liver. Abdom Imaging. 2000;25:89–92.CrossRefPubMed
9.
Zurück zum Zitat Lim JH, Yoon KH, Kim SH, et al. Intraductal papillary mucinous tumor of the bile ducts. Radiographics. 2004;24:53–67.CrossRefPubMed Lim JH, Yoon KH, Kim SH, et al. Intraductal papillary mucinous tumor of the bile ducts. Radiographics. 2004;24:53–67.CrossRefPubMed
10.
Zurück zum Zitat Yeh T-S, Tseng J-H, Chiu C-T, et al. Cholangiographic spectrum of intraductal papillary mucinous neoplasm of the bile ducts. Ann Surg. 2006;244:248–53.CrossRefPubMed Yeh T-S, Tseng J-H, Chiu C-T, et al. Cholangiographic spectrum of intraductal papillary mucinous neoplasm of the bile ducts. Ann Surg. 2006;244:248–53.CrossRefPubMed
11.
Zurück zum Zitat Hubens G, Delvaux G, Williams G, et al. Papillomatosis of the intra- and extrahepatic bile ducts with involvement of the pancreatic duct. Hepatogastroenterology. 1991;38:413–8.PubMed Hubens G, Delvaux G, Williams G, et al. Papillomatosis of the intra- and extrahepatic bile ducts with involvement of the pancreatic duct. Hepatogastroenterology. 1991;38:413–8.PubMed
12.
Zurück zum Zitat Kim HJ, Kim MH, Lee SK, et al. Mucin-hypersecreting bile duct tumor characterized by a striking homology with an intraductal papillary mucinous tumor (IPMT) of the pancreas. Endoscopy. 2000;32:389–93.CrossRefPubMed Kim HJ, Kim MH, Lee SK, et al. Mucin-hypersecreting bile duct tumor characterized by a striking homology with an intraductal papillary mucinous tumor (IPMT) of the pancreas. Endoscopy. 2000;32:389–93.CrossRefPubMed
13.
Zurück zum Zitat Oshikiri T, Kashimura N, Katanuma A, et al. Mucin-secreting bile duct adenoma—clinicopathological resemblance to intraductal papillary mucinous tumor of the pancreas. Dig Surg. 2002;19:324–7.CrossRefPubMed Oshikiri T, Kashimura N, Katanuma A, et al. Mucin-secreting bile duct adenoma—clinicopathological resemblance to intraductal papillary mucinous tumor of the pancreas. Dig Surg. 2002;19:324–7.CrossRefPubMed
14.
Zurück zum Zitat Shibahara H, Tamada S, Goto M, et al. Pathologic features of mucin-producing bile duct tumors. Two histopathologic categories as counterparts of pancreatic intraductal papillary mucinous neoplasms. Am J Surg Pathol. 2004;28:327–38.CrossRefPubMed Shibahara H, Tamada S, Goto M, et al. Pathologic features of mucin-producing bile duct tumors. Two histopathologic categories as counterparts of pancreatic intraductal papillary mucinous neoplasms. Am J Surg Pathol. 2004;28:327–38.CrossRefPubMed
15.
Zurück zum Zitat Kloppel G, Kosmahl M. Is the intraductal papillary mucinous neoplasia of the biliary tract a counterpart of pancreatic papillary mucinous neoplasm? J Hepatol. 2006;44:249–50.CrossRefPubMed Kloppel G, Kosmahl M. Is the intraductal papillary mucinous neoplasia of the biliary tract a counterpart of pancreatic papillary mucinous neoplasm? J Hepatol. 2006;44:249–50.CrossRefPubMed
16.
Zurück zum Zitat Zen Y, Fujii T, Itatsu K, et al. Biliary papillary tumors share pathological features with intraductal papillary mucinous neoplasm of the pancreas. Hepatology. 2006;44:1333–43.CrossRefPubMed Zen Y, Fujii T, Itatsu K, et al. Biliary papillary tumors share pathological features with intraductal papillary mucinous neoplasm of the pancreas. Hepatology. 2006;44:1333–43.CrossRefPubMed
17.
Zurück zum Zitat Chen TC, Nakanuma Y, Zen Y, et al. Intraductal papillary neoplasia of the liver associated with hepatolithiasis. Hepatology. 2001;34:651–8.CrossRefPubMed Chen TC, Nakanuma Y, Zen Y, et al. Intraductal papillary neoplasia of the liver associated with hepatolithiasis. Hepatology. 2001;34:651–8.CrossRefPubMed
18.
Zurück zum Zitat Jang K-T, Hong SM, Lee KT, et al. Intraductal papillary neoplasm of the bile duct associated with Clonorchis sinensis infection. Virchows Arch. 2008;453:589–98.CrossRefPubMed Jang K-T, Hong SM, Lee KT, et al. Intraductal papillary neoplasm of the bile duct associated with Clonorchis sinensis infection. Virchows Arch. 2008;453:589–98.CrossRefPubMed
19.
Zurück zum Zitat Tara T, Yamaguchi T, Ishihara T, et al. Diagnosis and patient management of intraductal papillary-mucinous tumor of the pancreas by using peroral pancreatoscopy and intraductal ultrasonography. Gastroenterology. 2002;122:34–43.CrossRef Tara T, Yamaguchi T, Ishihara T, et al. Diagnosis and patient management of intraductal papillary-mucinous tumor of the pancreas by using peroral pancreatoscopy and intraductal ultrasonography. Gastroenterology. 2002;122:34–43.CrossRef
20.
Zurück zum Zitat Lim JH, Jang K-T, Rhim HC, Kim YS, Lee KT, Choi SH. Biliary cystic intraductal papillary mucinous tumor and cystadenoma/cystadenocarcinoma: differentiation by CT. Abdom Imaging. 2007;32:644–51.CrossRefPubMed Lim JH, Jang K-T, Rhim HC, Kim YS, Lee KT, Choi SH. Biliary cystic intraductal papillary mucinous tumor and cystadenoma/cystadenocarcinoma: differentiation by CT. Abdom Imaging. 2007;32:644–51.CrossRefPubMed
21.
Zurück zum Zitat Lim JH, Kim MH, Kim TK, et al. Papillary neoplasms of the bile duct that mimic biliary stone disease. Radiographics. 2003;23:447–55.CrossRefPubMed Lim JH, Kim MH, Kim TK, et al. Papillary neoplasms of the bile duct that mimic biliary stone disease. Radiographics. 2003;23:447–55.CrossRefPubMed
22.
Zurück zum Zitat Lim JH, Jang K-T, Choi D. Biliary intraductal papillary mucinous neoplasm presenting only as dilation of the hepatic lobar or segmental bile ducts: imaging features in six patients. AJR Am J Roentgenol 2008;191:778–82CrossRefPubMed Lim JH, Jang K-T, Choi D. Biliary intraductal papillary mucinous neoplasm presenting only as dilation of the hepatic lobar or segmental bile ducts: imaging features in six patients. AJR Am J Roentgenol 2008;191:778–82CrossRefPubMed
Metadaten
Titel
Mucin-producing bile duct tumors: radiological–pathological correlation and diagnostic strategy
verfasst von
Jae Hoon Lim
Kee-Taek Jang
Publikationsdatum
01.05.2010
Verlag
Springer Japan
Erschienen in
Journal of Hepato-Biliary-Pancreatic Sciences / Ausgabe 3/2010
Print ISSN: 1868-6974
Elektronische ISSN: 1868-6982
DOI
https://doi.org/10.1007/s00534-009-0154-y

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