Introduction
Methods
Patients
Treatment
Study design
Endpoints
Statistical analysis
Results
Patients
Sex, female/male, n (%) | 30 (37.0)/51 (63.0) |
Age, years, median (range) | 35.9 (15–70) |
Body mass index, mean (SD) | 20.1 (3.3) |
Disease, CD/UC, n (%) | 34 (42.0)/47 (58.0) |
Disease duration, years, mean (SD) | 5.9 (6.7) |
Disease location in CD, ileitis/colitis/ileocolitis, n (%) | 3 (8.8)/4 (11.8)/27 (79.4) |
Disease location in UC, left-sided/extensive, n (%) | 16 (34.0)/31 (66.0) |
Perianal lesion in CD, n (%) | 21 (61.8) |
Concomitant medications | |
5-aminosalycilic acid, n (%) | 70 (86.4) |
Thiopurine, n (%) | 29 (35.8) |
Corticosteroid, n (%) | 43 (53.1) |
Previous use of biologics, n (%) | 8 (9.9) |
History of bowel surgery in CD, n (%) | 8 (23.5) |
Current smoker, n (%) | 3 (3.7) |
Laboratory data | |
LRG (µg/ml), n = 80, mean (SD) | 27.4 (12.6) |
CRP (mg/dl), n = 80, mean (SD) | 1.69 (2.29) |
fCal (µg/g), n = 71, mean (SD) | 5867 (6766) |
CDAI in CD, mean (SD) | 271.5 (55.5) |
SES-CD in CD, n = 33, mean (SD) | 17.3 (7.5) |
PMS in UC, mean (SD) | 5.9 (1.3) |
MES in UC, n = 45, mean (SD) | 2.3 (0.6) |
Changes in disease activity upon initiation of adalimumab therapy
Decreased serum LRG, CRP, and fCal levels with adalimumab treatment
LRG, CRP, and fCal levels at each time point in patients with and without endoscopic remission at week 52
Correlation between disease activity and biomarkers
Week 0 | Week 12 | Week 24 | Week 52 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | r | p | n | r | p | n | r | p | n | r | p | ||
CDAI (CD) | LRG | 34 | 0.233 | 0.1851 | 33 | 0.440 | 0.0105 | 33 | 0.743 | < 0.0001 | 28 | 0.554 | 0.0022 |
CRP | 34 | 0.375 | 0.0287 | 33 | 0.339 | 0.0540 | 33 | 0.622 | 0.0001 | 28 | 0.597 | 0.0008 | |
fCal | 32 | −0.097 | 0.5982 | 31 | 0.014 | 0.9387 | 32 | 0.204 | 0.2616 | 27 | 0.600 | 0.0009 | |
PMS (UC) | LRG | 46 | 0.503 | 0.0004 | 36 | 0.402 | 0.0151 | 31 | 0.376 | 0.0368 | 27 | 0.398 | 0.0398 |
CRP | 46 | 0.440 | 0.0022 | 35 | 0.372 | 0.0280 | 32 | 0.441 | 0.0115 | 27 | 0.072 | 0.7204 | |
fCal | 39 | 0.108 | 0.5117 | 36 | 0.411 | 0.0127 | 31 | 0.327 | 0.0730 | 24 | 0.494 | 0.0141 |
Correlation between endoscopic activity and biomarkers
Week 0 | Week 12 | Week 24 | Week 52 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | r | p | n | r | p | n | r | p | n | r | p | ||
SES-CD (CD) | LRG | 33 | 0.391 | 0.0244 | – | – | – | 27 | 0.563 | 0.0022 | 25 | 0.697 | 0.0001 |
CRP | 33 | 0.107 | 0.5536 | – | – | – | 27 | 0.470 | 0.0134 | 25 | 0.384 | 0.0582 | |
fCal | 31 | 0.300 | 0.1005 | – | – | – | 26 | 0.659 | 0.0003 | 25 | 0.593 | 0.0398 | |
MES (UC) | LRG | 45 | 0.534 | 0.0002 | 31 | 0.429 | 0.0159 | – | – | – | 27 | 0.335 | 0.0877 |
CRP | 45 | 0.538 | 0.0001 | 30 | 0.234 | 0.2137 | – | – | – | 27 | − 0.022 | 0.9134 | |
fCal | 38 | 0.194 | 0.2430 | 31 | 0.448 | 0.0116 | – | – | – | 24 | 0.393 | 0.0578 |