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01.02.2015 | Original Article

Comparison of epinephrine and felypressin pressure effects in 1K1C hypertensive rats treated or not with atenolol

verfasst von: Camila A. Fleury, Vagner C. Andreo, Pedro C. Lomba, Thiago J. Dionísio, Sandra L. Amaral, Carlos F. Santos, Flávio A. Faria

Erschienen in: Journal of Anesthesia | Ausgabe 1/2015

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Abstract

Purpose

Epinephrine is considered the gold standard vasoconstrictor for hypertensive patients, but few studies report felypressin’s effects. The present study aimed to analyze and compare the effects of these two vasoconstrictors, injected by the intravenous route, on the arterial pressure of normotensive, hypertensive and atenolol-treated hypertensive rats.

Method

The hypertension model was one-kidney-one-clip (1K1C): the main left renal artery was partially constricted and the right kidney was surgically removed in 45-day-old male Wistar rats. 1K1C hypertensive rats received atenolol (90 mg/kg/day) by gavage for 2 weeks. 28–35 days after hypertension induction, a catheter was inserted into the left carotid artery to record direct blood pressure values. The following parameters were recorded: minimal hypotensive response, maximal hypertensive response, response duration and heart rate.

Results

Epinephrine, but not felypressin, exerted an important hypotensive action; non-treated hypertensive rats showed more pronounced vasodilation. Treated and non-treated rats showed hypertensive responses of the same magnitudes in all groups; 1K1C atenolol rats showed reduced hypertensive responses to both vasoconstrictors. Felypressin’s response duration was longer than that of epinephrine in all groups. Epinephrine increased heart rate while felypressin reduced this parameter only in the normotensive group.

Conclusions

Our results suggest that felypressin has equipotent pressure responses when compared with epinephrine, showing a greater extent of action. Atenolol’s reduction of hypertensive effects surprisingly suggests that atenolol β-blockade may also be important for felypressin’s cardiovascular effect, as is widely known for epinephrine. Our data suggest that felypressin is safe for hypertensive subjects, in particular those receiving atenolol.

Salonen M, Forssell H, Scheinin M. Local dental anaesthesia with lidocaine and adrenaline. Effects on plasma catecholamines, heart rate and blood pressure. Int J Oral Maxillofac Surg. 1988;17:392–4.CrossRefPubMed

Cecanho R, De Luca LA, Ranali J. Cardiovascular effects of felypressin. Anesth Prog. 2006;53:119–25.CrossRefPubMedCentralPubMed

Herman WW, Konzelman JL, Prisant LM, Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. New national guidelines on hypertension: a summary for dentistry. J Am Dent Assoc. 2004;135:576–84 (quiz 653–574).CrossRefPubMed

Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jones DW, Materson BJ, Oparil S, Wright JT, Roccella EJ, National Heart L, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, Committee NHBPEPC. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003;289:2560–72.CrossRefPubMed

Glick M. New guidelines for prevention, detection, evaluation and treatment of high blood pressure. J Am Dent Assoc. 1998;129:1588–94.CrossRefPubMed

Niwa H, Sato Y, Matsuura H. Safety of dental treatment in patients with previously diagnosed acute myocardial infarction or unstable angina pectoris. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89:35–41.CrossRefPubMed

Meechan JG, Parry G, Rattray DT, Thomason JM. Effects of dental local anaesthetics in cardiac transplant recipients. Br Dent J. 2002;192:161–3.CrossRefPubMed

Nobre F, da Silva CA, Coelho EB, Salgado HC, Fazan R. Antihypertensive agents have different ability to modulate arterial pressure and heart rate variability in 2k1c rats. Am J Hypertens. 2006;19:1079–83.CrossRefPubMed

Faria FA, Salgado MC. Facilitation of noradrenergic transmission by angiotensin in hypertensive rats. Hypertension. 1992;19:II30–5.CrossRefPubMed

10.

Covino BG. Systemic toxicity of local anesthetic agents. Anesth Analg. 1978;57:387–8.PubMed

11.

Yagiela JA. Local anesthetics: a century of progress. Anesth Prog. 1985;32:47–56.PubMedCentralPubMed

12.

Redfors B, Shao Y, Omerovic E. Influence of anesthetic agent, depth of anesthesia and body temperature on cardiovascular functional parameters in the rat. Lab Anim. 2014;48:6–14.CrossRefPubMed

13.

Adams HR, Parker JL, Mathew BP. The influence of ketamine on inotropic and chronotropic responsiveness of heart muscle. J Pharmacol Exp Ther. 1977;201:171–83.PubMed

14.

Hiley CR, Nichols AJ, Thomas GR. Interactions between noradrenaline and alpha 2-adrenoceptor agonists in the superior mesenteric arterial bed of the rat. Br J Pharmacol. 1986;89:779–85.CrossRefPubMedCentralPubMed

15.

Meechan J, Cole B, Welbury R. The influence of two different dental local anaesthetic solutions on the haemodynamic responses of children undergoing restorative dentistry: a randomised, single-blind, split-mouth study. Br Dent J. 2001;190:502–4.PubMed

16.

Meechan J, Welbury R. Metabolic responses to oral surgery under local anesthesia and sedation with intravenous midazolam: the effects of two different local anesthetics. Anesth Prog. 1992;39:9–12.PubMedCentralPubMed

17.

Martignoni M, Groothuis GM, de Kanter R. Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Expert Opin Drug Metab Toxicol. 2006;2:875–94.CrossRefPubMed

18.

Little JW. The impact on dentistry of recent advances in the management of hypertension. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90:591–9.CrossRefPubMed

19.

Oliveira N, Gazola R, Singi G. Effects of vasoconstrictors used in local anesthesia upon isolated rat heart. Pharmacol Res. 2002;46:15–8.CrossRefPubMed

20.

Oliveira NS, Gazola R, Patez PS, Singi G. Effects of the prilocaine and of the association of prilocaine with different vasoconstrictors on the isolated hearts of rats. Pharmacol Res. 2003;48:325–8.CrossRefPubMed

21.

Bronzo AL, Cardoso CG, Ortega KC, Mion D. Felypressin increases blood pressure during dental procedures in hypertensive patients. Arq Bras Cardiol. 2012;99:724–31.CrossRefPubMed

22.

Yagiela JA. Adverse drug interactions in dental practice: interactions associated with vasoconstrictors. Part V of a series. J Am Dent Assoc. 1999;130:701–9.CrossRefPubMed

23.

Hersh EV, Giannakopoulos H. Beta-adrenergic blocking agents and dental vasoconstrictors. Dent Clin North Am. 2010;54:687–96.CrossRefPubMed

24.

Zhang C, Banting DW, Gelb AW, Hamilton JT. Effect of beta-adrenoreceptor blockade with nadolol on the duration of local anesthesia. J Am Dent Assoc. 1999;130:1773–80.CrossRefPubMed

25.

Kawano Y, Matsuoka H, Nishikimi T, Takishita S, Omae T. The role of vasopressin in essential hypertension. Plasma levels and effects of the V1 receptor antagonist OPC-21268 during different dietary sodium intakes. Am J Hypertens. 1997;10:1240–4.CrossRefPubMed

26.

Singi G, Oliveira NS, Araujo L, Singi M. Hemodynamic effects of felypressin and epinephrine on anesthetized rats. J Anesth. 2003;17:204–5.CrossRefPubMed

27.

Jackson E. Vasopressin and other agents affecting the renal conservation of water. Goodman and Gilman’s the pharmacological basis of therapeutics. New York: McGraw-Hill, Inc.; 2006. p. 771–788.

28.

Bannay R, Böhm M, Husain A. Heart rate differentiates urgency and emergency in hypertensive crisis. Clin Res Cardiol. 2013;102:593–8.CrossRefPubMed

Titel: Comparison of epinephrine and felypressin pressure effects in 1K1C hypertensive rats treated or not with atenolol
verfasst von: Camila A. Fleury
Vagner C. Andreo
Pedro C. Lomba
Thiago J. Dionísio
Sandra L. Amaral
Carlos F. Santos
Flávio A. Faria
Publikationsdatum: 01.02.2015
Verlag: Springer Japan
Erschienen in: Journal of Anesthesia / Ausgabe 1/2015
Print ISSN: 0913-8668
Elektronische ISSN: 1438-8359
DOI: https://doi.org/10.1007/s00540-014-1866-y

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Comparison of epinephrine and felypressin pressure effects in 1K1C hypertensive rats treated or not with atenolol

Abstract

Purpose

Method

Results

Conclusions

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Springer Medizin

Abstract

Purpose

Method

Results

Conclusions

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