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Journal of Anesthesia
Erschienen in: Journal of Anesthesia 1/2019

17.11.2018 | Invited Review Article

Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain

verfasst von: Megumi Matsuda, Yul Huh, Ru-Rong Ji

Erschienen in: Journal of Anesthesia | Ausgabe 1/2019

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Abstract

Inflammation is the body’s response to injury and infection, involving a complex biological response of the somatosensory, immune, autonomic, and vascular systems. Inflammatory mediators such as prostaglandin, proinflammatory cytokines, and chemokines induce pain via direct activation of nociceptors, the primary sensory neurons that detect noxious stimuli. Neurogenic inflammation is triggered by nerve activation and results in neuropeptide release and rapid plasma extravasation and edema, contributing to pain conditions such as headache. Neuroinflammation is a localized inflammation in the peripheral nervous system (PNS) and central nervous system (CNS). A characteristic feature of neuroinflammation is the activation of glial cells in dorsal root ganglia, spinal cord, and brain which leads to the production of proinflammatory cytokines and chemokines in the PNS and CNS that drives peripheral sensitization and central sensitization. Here, we discuss the distinct roles of inflammation, neurogenic inflammation, and neuroinflammation in the regulation of different types of pain conditions, with a special focus on neuroinflammation in postoperative pain and opioid-induced hyperalgesia.
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Metadaten
Titel
Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain
verfasst von
Megumi Matsuda
Yul Huh
Ru-Rong Ji
Publikationsdatum
17.11.2018
Verlag
Springer Japan
Erschienen in
Journal of Anesthesia / Ausgabe 1/2019
Print ISSN: 0913-8668
Elektronische ISSN: 1438-8359
DOI
https://doi.org/10.1007/s00540-018-2579-4

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