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European Spine Journal

Erschienen in:

01.12.2008 | Review

Quantitative MRI as a diagnostic tool of intervertebral disc matrix composition and integrity

verfasst von: Fackson Mwale, James C. Iatridis, John Antoniou

Erschienen in: European Spine Journal | Sonderheft 4/2008

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Abstract

Degenerative disc disease has been implicated as a major component of spine pathology. The current major clinical procedures for treating disc degeneration have been disappointing, because of altered spinal mechanics leading to subsequent degeneration at adjacent disc levels. Disc pathology treatment is shifting toward prevention and treatment of underlying etiologic processes at the level of the disc matrix composition and integrity and the biomechanics of the disc. The ability to perform such treatment relies on one’s ability to accurately and objectively assess the state of the matrix and the effectiveness of treatment by a non-invasive technique. In this review, we will summarize our advances in efforts to develop an objective, accurate, non-invasive diagnostic tool (quantitative MRI) in the detection and quantification of matrix composition and integrity and of biomechanical changes in early intervertebral disc degeneration.

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Titel: Quantitative MRI as a diagnostic tool of intervertebral disc matrix composition and integrity
verfasst von: Fackson Mwale
James C. Iatridis
John Antoniou
Publikationsdatum: 01.12.2008
Verlag: Springer-Verlag
Erschienen in: European Spine Journal / Ausgabe Sonderheft 4/2008
Print ISSN: 0940-6719
Elektronische ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-008-0744-4

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