Skip to main content
Erschienen in: European Spine Journal 2/2015

01.02.2015 | Review Article

Idiopathic scoliosis and the vestibular system

verfasst von: Ammar H. Hawasli, Timothy E. Hullar, Ian G. Dorward

Erschienen in: European Spine Journal | Ausgabe 2/2015

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Despite its high prevalence, the etiology underlying idiopathic scoliosis remains unclear. Although initial scrutiny has focused on genetic, biochemical, biomechanical, nutritional and congenital causes, there is growing evidence that aberrations in the vestibular system may play a role in the etiology of scoliosis. In this article, we discuss putative mechanisms for adolescent idiopathic scoliosis and review the current evidence supporting a role for the vestibular system in adolescent idiopathic scoliosis.

Methods

A comprehensive search of the English literature was performed using PubMed (http://​www.​ncbi.​nlm.​nih.​gov/​pubmed). Research articles studying interactions between adolescent idiopathic scoliosis and the vestibular system were selected and evaluated for inclusion in a literature review.

Results

Eighteen manuscripts of level 3–4 clinical evidence to support an association between adolescent idiopathic scoliosis (AIS) and dysfunction of the vestibular system were identified. These studies include data from physiologic and morphologic studies in humans. Clinical data are supported by animal model studies to suggest a causative link between the vestibular system and AIS.

Conclusions

Clinical data and a limited number of animal model studies suggest a causative role of the vestibular system in AIS, although this association has not been reproduced in all studies.
Literatur
1.
Zurück zum Zitat Barra J, Marquer A, Joassin R, Reymond C, Metge L, Chauvineau V et al (2010) Humans use internal models to construct and update a sense of verticality. Brain 133:3552–3563PubMedCrossRef Barra J, Marquer A, Joassin R, Reymond C, Metge L, Chauvineau V et al (2010) Humans use internal models to construct and update a sense of verticality. Brain 133:3552–3563PubMedCrossRef
2.
Zurück zum Zitat Cakrt O, Slaby K, Viktorinova L, Kolar P, Jerabek J (2011) Subjective visual vertical in patients with idiopatic scoliosis. J Vestib Res 21:161–165PubMed Cakrt O, Slaby K, Viktorinova L, Kolar P, Jerabek J (2011) Subjective visual vertical in patients with idiopatic scoliosis. J Vestib Res 21:161–165PubMed
3.
Zurück zum Zitat De Waele C, Graf W, Josset P, Vidal PP (1989) A radiological analysis of the postural syndromes following hemilabyrinthectomy and selective canal and otolith lesions in the guinea pig. Exp Brain Res 77:166–182PubMedCrossRef De Waele C, Graf W, Josset P, Vidal PP (1989) A radiological analysis of the postural syndromes following hemilabyrinthectomy and selective canal and otolith lesions in the guinea pig. Exp Brain Res 77:166–182PubMedCrossRef
4.
Zurück zum Zitat Deguchi M, Kawakami N, Kanemura T (1997) Correction of experimental scoliosis by rib resection in the transverse plane. J Spinal Disord 10:197–203PubMedCrossRef Deguchi M, Kawakami N, Kanemura T (1997) Correction of experimental scoliosis by rib resection in the transverse plane. J Spinal Disord 10:197–203PubMedCrossRef
5.
Zurück zum Zitat Deguchi M, Kawakami N, Kanemura T, Mimatsu K, Iwata H (1995) Experimental scoliosis induced by rib resection in chickens. J Spinal Disord 8:179–185PubMedCrossRef Deguchi M, Kawakami N, Kanemura T, Mimatsu K, Iwata H (1995) Experimental scoliosis induced by rib resection in chickens. J Spinal Disord 8:179–185PubMedCrossRef
6.
Zurück zum Zitat Fong DY, Lee CF, Cheung KM, Cheng JC, Ng BK, Lam TP et al (2010) A meta-analysis of the clinical effectiveness of school scoliosis screening. Spine (Phila Pa 1976) 35:1061–1071 Fong DY, Lee CF, Cheung KM, Cheng JC, Ng BK, Lam TP et al (2010) A meta-analysis of the clinical effectiveness of school scoliosis screening. Spine (Phila Pa 1976) 35:1061–1071
7.
Zurück zum Zitat Gauchard GC, Lascombes P, Kuhnast M, Perrin PP (2001) Influence of different types of progressive idiopathic scoliosis on static and dynamic postural control. Spine (Phila Pa 1976) 26:1052–1058CrossRef Gauchard GC, Lascombes P, Kuhnast M, Perrin PP (2001) Influence of different types of progressive idiopathic scoliosis on static and dynamic postural control. Spine (Phila Pa 1976) 26:1052–1058CrossRef
8.
Zurück zum Zitat Gruber AH, Busa MA, Gorton IGE, Van Emmerik RE, Masso PD, Hamill J (2011) Time-to-contact and multiscale entropy identify differences in postural control in adolescent idiopathic scoliosis. Gait Posture 34:13–18PubMedCrossRef Gruber AH, Busa MA, Gorton IGE, Van Emmerik RE, Masso PD, Hamill J (2011) Time-to-contact and multiscale entropy identify differences in postural control in adolescent idiopathic scoliosis. Gait Posture 34:13–18PubMedCrossRef
9.
Zurück zum Zitat Guo X, Chau WW, Hui-Chan CW, Cheung CS, Tsang WW, Cheng JC (2006) Balance control in adolescents with idiopathic scoliosis and disturbed somatosensory function. Spine (Phila Pa 1976) 31:E437–E440CrossRef Guo X, Chau WW, Hui-Chan CW, Cheung CS, Tsang WW, Cheng JC (2006) Balance control in adolescents with idiopathic scoliosis and disturbed somatosensory function. Spine (Phila Pa 1976) 31:E437–E440CrossRef
10.
Zurück zum Zitat Haumont T, Gauchard GC, Lascombes P, Perrin PP (2011) Postural instability in early-stage idiopathic scoliosis in adolescent girls. Spine (Phila Pa 1976) 36:E847–E854CrossRef Haumont T, Gauchard GC, Lascombes P, Perrin PP (2011) Postural instability in early-stage idiopathic scoliosis in adolescent girls. Spine (Phila Pa 1976) 36:E847–E854CrossRef
11.
Zurück zum Zitat Janssen MM, de Wilde RF, Kouwenhoven JW, Castelein RM (2011) Experimental animal models in scoliosis research: a review of the literature. Spine J 11:347–358PubMedCrossRef Janssen MM, de Wilde RF, Kouwenhoven JW, Castelein RM (2011) Experimental animal models in scoliosis research: a review of the literature. Spine J 11:347–358PubMedCrossRef
12.
Zurück zum Zitat Joassin R, Bonniaud V, Barra J, Marquer A, Perennou D (2010) Somaesthetic perception of the vertical in spinal cord injured patients: a clinical study. Ann Phys Rehabil Med 53:568–574PubMedCrossRef Joassin R, Bonniaud V, Barra J, Marquer A, Perennou D (2010) Somaesthetic perception of the vertical in spinal cord injured patients: a clinical study. Ann Phys Rehabil Med 53:568–574PubMedCrossRef
13.
Zurück zum Zitat Kanemura T, Kawakami N, Deguchi M, Mimatsu K, Iwata H (1997) Natural course of experimental scoliosis in pinealectomized chickens. Spine (Phila Pa 1976) 22:1563–1567CrossRef Kanemura T, Kawakami N, Deguchi M, Mimatsu K, Iwata H (1997) Natural course of experimental scoliosis in pinealectomized chickens. Spine (Phila Pa 1976) 22:1563–1567CrossRef
14.
Zurück zum Zitat Kouwenhoven JW, Castelein RM (2008) The pathogenesis of adolescent idiopathic scoliosis: review of the literature. Spine (Phila Pa 1976) 33:2898–2908CrossRef Kouwenhoven JW, Castelein RM (2008) The pathogenesis of adolescent idiopathic scoliosis: review of the literature. Spine (Phila Pa 1976) 33:2898–2908CrossRef
15.
Zurück zum Zitat Kuo FC, Hong CZ, Lai CL, Tan SH (2011) Postural control strategies related to anticipatory perturbation and quick perturbation in adolescent idiopathic scoliosis. Spine (Phila Pa 1976) 36:810–816CrossRef Kuo FC, Hong CZ, Lai CL, Tan SH (2011) Postural control strategies related to anticipatory perturbation and quick perturbation in adolescent idiopathic scoliosis. Spine (Phila Pa 1976) 36:810–816CrossRef
16.
Zurück zum Zitat Kuo FC, Wang NH, Hong CZ (2010) Impact of visual and somatosensory deprivation on dynamic balance in adolescent idiopathic scoliosis. Spine (Phila Pa 1976) 35:2084–2090CrossRef Kuo FC, Wang NH, Hong CZ (2010) Impact of visual and somatosensory deprivation on dynamic balance in adolescent idiopathic scoliosis. Spine (Phila Pa 1976) 35:2084–2090CrossRef
17.
Zurück zum Zitat Lambert FM, Malinvaud D, Glaunès J, Bergot C, Straka H, Vidal P-P (2009) Vestibular asymmetry as the cause of idiopathic scoliosis: a possible answer from Xenopus. J Neurosci 29:12477–12483PubMedCrossRef Lambert FM, Malinvaud D, Glaunès J, Bergot C, Straka H, Vidal P-P (2009) Vestibular asymmetry as the cause of idiopathic scoliosis: a possible answer from Xenopus. J Neurosci 29:12477–12483PubMedCrossRef
18.
Zurück zum Zitat Lao ML, Chow DH, Guo X, Cheng JC, Holmes AD (2008) Impaired dynamic balance control in adolescents with idiopathic scoliosis and abnormal somatosensory evoked potentials. J Pediatr Orthop 28:846–849PubMedCrossRef Lao ML, Chow DH, Guo X, Cheng JC, Holmes AD (2008) Impaired dynamic balance control in adolescents with idiopathic scoliosis and abnormal somatosensory evoked potentials. J Pediatr Orthop 28:846–849PubMedCrossRef
19.
Zurück zum Zitat Lion A, Haumont T, Gauchard GC, Wiener-Vacher SR, Lascombes P, Perrin PP (2013) Visuo-oculomotor deficiency at early-stage idiopathic scoliosis in adolescent girls. Spine (Phila Pa 1976) 38:238–244CrossRef Lion A, Haumont T, Gauchard GC, Wiener-Vacher SR, Lascombes P, Perrin PP (2013) Visuo-oculomotor deficiency at early-stage idiopathic scoliosis in adolescent girls. Spine (Phila Pa 1976) 38:238–244CrossRef
20.
Zurück zum Zitat Lombardi G, Akoume MY, Colombini A, Moreau A, Banfi G (2011) Biochemistry of adolescent idiopathic scoliosis. Adv Clin Chem 54:165–182PubMedCrossRef Lombardi G, Akoume MY, Colombini A, Moreau A, Banfi G (2011) Biochemistry of adolescent idiopathic scoliosis. Adv Clin Chem 54:165–182PubMedCrossRef
21.
Zurück zum Zitat Machida M, Dubousset J, Imamura Y, Iwaya T, Yamada T, Kimura J (1993) An experimental study in chickens for the pathogenesis of idiopathic scoliosis. Spine (Phila Pa 1976) 18:1609–1615CrossRef Machida M, Dubousset J, Imamura Y, Iwaya T, Yamada T, Kimura J (1993) An experimental study in chickens for the pathogenesis of idiopathic scoliosis. Spine (Phila Pa 1976) 18:1609–1615CrossRef
22.
Zurück zum Zitat Machida M, Dubousset J, Imamura Y, Iwaya T, Yamada T, Kimura J et al (1994) Pathogenesis of idiopathic scoliosis: SEPs in chicken with experimentally induced scoliosis and in patients with idiopathic scoliosis. J Pediatr Orthop 14:329–335PubMedCrossRef Machida M, Dubousset J, Imamura Y, Iwaya T, Yamada T, Kimura J et al (1994) Pathogenesis of idiopathic scoliosis: SEPs in chicken with experimentally induced scoliosis and in patients with idiopathic scoliosis. J Pediatr Orthop 14:329–335PubMedCrossRef
23.
Zurück zum Zitat Machida M, Dubousset J, Satoh T, Murai I, Wood KB, Yamada T et al (2001) Pathologic mechanism of experimental scoliosis in pinealectomized chickens. Spine (Phila Pa 1976) 26:E385–E391CrossRef Machida M, Dubousset J, Satoh T, Murai I, Wood KB, Yamada T et al (2001) Pathologic mechanism of experimental scoliosis in pinealectomized chickens. Spine (Phila Pa 1976) 26:E385–E391CrossRef
24.
Zurück zum Zitat Machida M, Murai I, Miyashita Y, Dubousset J, Yamada T, Kimura J (1999) Pathogenesis of idiopathic scoliosis. Experimental study in rats. Spine (Phila Pa 1976) 24:1985–1989CrossRef Machida M, Murai I, Miyashita Y, Dubousset J, Yamada T, Kimura J (1999) Pathogenesis of idiopathic scoliosis. Experimental study in rats. Spine (Phila Pa 1976) 24:1985–1989CrossRef
25.
Zurück zum Zitat Machida M, Yamada H, Yamada T, Kimura J, Saito M, Shibasaki K (2005) Rib length in experimental scoliosis induced by pinealectomy in chickens. Spine (Phila Pa 1976) 30:E692–E696CrossRef Machida M, Yamada H, Yamada T, Kimura J, Saito M, Shibasaki K (2005) Rib length in experimental scoliosis induced by pinealectomy in chickens. Spine (Phila Pa 1976) 30:E692–E696CrossRef
26.
Zurück zum Zitat Mallau S, Bollini G, Jouve JCA (2007) Locomotor skills and balance strategies in adolescents idiopathic scoliosis. Spine 32:E14–E22PubMedCrossRef Mallau S, Bollini G, Jouve JCA (2007) Locomotor skills and balance strategies in adolescents idiopathic scoliosis. Spine 32:E14–E22PubMedCrossRef
27.
Zurück zum Zitat Mirovsky Y, Blankstein A, Shlamkovitch N (2006) Postural control in patients with severe idiopathic scoliosis: a prospective study. J Pediatr Orthop B 15:168–171PubMedCrossRef Mirovsky Y, Blankstein A, Shlamkovitch N (2006) Postural control in patients with severe idiopathic scoliosis: a prospective study. J Pediatr Orthop B 15:168–171PubMedCrossRef
28.
Zurück zum Zitat Monticelli G, Ascani E, Salsano V, Salsano A (1975) Experimental scoliosis induced by prolonged minimal electrical stimulation of the paravertebral muscles. Ital J Orthop Traumatol 1:39–54PubMed Monticelli G, Ascani E, Salsano V, Salsano A (1975) Experimental scoliosis induced by prolonged minimal electrical stimulation of the paravertebral muscles. Ital J Orthop Traumatol 1:39–54PubMed
29.
Zurück zum Zitat Flint PW, Haughey BH, Lund VJ, Niparko JK, Richardson MA, Robbins KT (eds) (2010) Cummings Otolaryngology Head and Neck Surgery, ed 5. Elsevier, Philadelphia Flint PW, Haughey BH, Lund VJ, Niparko JK, Richardson MA, Robbins KT (eds) (2010) Cummings Otolaryngology Head and Neck Surgery, ed 5. Elsevier, Philadelphia
30.
Zurück zum Zitat Rousie D, Deroubaix J, Joly O, Baudrillard JC, Berthoz A (2009) Abnormal connection between lateral and posterior semicircular canal revealed by new modeling process. Ann N Y Acad Sci 1164:435–457CrossRef Rousie D, Deroubaix J, Joly O, Baudrillard JC, Berthoz A (2009) Abnormal connection between lateral and posterior semicircular canal revealed by new modeling process. Ann N Y Acad Sci 1164:435–457CrossRef
31.
Zurück zum Zitat Rousie D, Hache J, Pellerin P, Deroubaix J, Tichelen P, Berthoz A (1999) Occulomotor, postural, and perceptual assymmetries associated with a common cause. Ann N Y Acad Sci 871:439–446PubMedCrossRef Rousie D, Hache J, Pellerin P, Deroubaix J, Tichelen P, Berthoz A (1999) Occulomotor, postural, and perceptual assymmetries associated with a common cause. Ann N Y Acad Sci 871:439–446PubMedCrossRef
32.
Zurück zum Zitat Sahlstrand T, Petruson B (1979) A study of labyrinthine function in patients with adolescent idiopathic scoliosis. I. An electro-nystagmographic study. Acta Orthop Scand 50:759–769PubMedCrossRef Sahlstrand T, Petruson B (1979) A study of labyrinthine function in patients with adolescent idiopathic scoliosis. I. An electro-nystagmographic study. Acta Orthop Scand 50:759–769PubMedCrossRef
33.
Zurück zum Zitat Sahlstrand T, Petruson B, Ortengren R (1979) Vestibulospinal reflex activity in patients with adolescent idiopathic scoliosis. Postural effects during caloric labyrinthine stimulation recorded by stabilometry. Acta Orthop Scand 50:275–281PubMedCrossRef Sahlstrand T, Petruson B, Ortengren R (1979) Vestibulospinal reflex activity in patients with adolescent idiopathic scoliosis. Postural effects during caloric labyrinthine stimulation recorded by stabilometry. Acta Orthop Scand 50:275–281PubMedCrossRef
34.
Zurück zum Zitat Sahlstrend T, Lidstrom J (1980) Equilibrium factors as predictors of the progrnosis in adolescent idiopathic scoliolosis. Clin Orthop Relat Res (152):232–236 Sahlstrend T, Lidstrom J (1980) Equilibrium factors as predictors of the progrnosis in adolescent idiopathic scoliolosis. Clin Orthop Relat Res (152):232–236
35.
Zurück zum Zitat Sahlstrend T, Petruson B (1979) Postural effects on nystagmus response during caloric labyrinthine stimulation in patients with adolescent idiopathic scoliosis. II. An electro-nystagmographic study. Acta Orthop Scand 50:771–775PubMedCrossRef Sahlstrend T, Petruson B (1979) Postural effects on nystagmus response during caloric labyrinthine stimulation in patients with adolescent idiopathic scoliosis. II. An electro-nystagmographic study. Acta Orthop Scand 50:771–775PubMedCrossRef
36.
Zurück zum Zitat Shi L, Wang D, Chu WC, Burwell GR, Wong TT, Heng PA et al (2011) Automatic MRI segmentation and morphoanatomy analysis of the vestibular system in adolescent idiopathic scoliosis. Neuroimage 54(Suppl 1):S180–S188PubMedCrossRef Shi L, Wang D, Chu WC, Burwell GR, Wong TT, Heng PA et al (2011) Automatic MRI segmentation and morphoanatomy analysis of the vestibular system in adolescent idiopathic scoliosis. Neuroimage 54(Suppl 1):S180–S188PubMedCrossRef
37.
Zurück zum Zitat Shi L, Wang D, Chu WC, Burwell RG, Freeman BJ, Heng PA et al (2009) Volume-based morphometry of brain MR images in adolescent idiopathic scoliosis and healthy control subjects. AJNR Am J Neuroradiol 30:1302–1307PubMedCrossRef Shi L, Wang D, Chu WC, Burwell RG, Freeman BJ, Heng PA et al (2009) Volume-based morphometry of brain MR images in adolescent idiopathic scoliosis and healthy control subjects. AJNR Am J Neuroradiol 30:1302–1307PubMedCrossRef
38.
Zurück zum Zitat Simoneau M, Lamothe V, Hutin E, Mercier P, Teasdale N, Blouin J (2009) Evidence for cognitive vestibular integration impairment in idiopathic scoliosis patients. BMC Neurosci 10:102PubMedCentralPubMedCrossRef Simoneau M, Lamothe V, Hutin E, Mercier P, Teasdale N, Blouin J (2009) Evidence for cognitive vestibular integration impairment in idiopathic scoliosis patients. BMC Neurosci 10:102PubMedCentralPubMedCrossRef
39.
Zurück zum Zitat Simoneau M, Mercier P, Blouin J, Allard P, Teasdale N (2006) Altered sensory-weighting mechanisms is observed in adolescents with idiopathic scoliosis. BMC Neurosci 7:68PubMedCentralPubMedCrossRef Simoneau M, Mercier P, Blouin J, Allard P, Teasdale N (2006) Altered sensory-weighting mechanisms is observed in adolescents with idiopathic scoliosis. BMC Neurosci 7:68PubMedCentralPubMedCrossRef
40.
Zurück zum Zitat Simoneau M, Richer N, Mercier P, Allard P, Teasdale N (2006) Sensory deprivation and balance control in idiopathic scoliosis adolescent. Exp Brain Res 170:576–582PubMedCrossRef Simoneau M, Richer N, Mercier P, Allard P, Teasdale N (2006) Sensory deprivation and balance control in idiopathic scoliosis adolescent. Exp Brain Res 170:576–582PubMedCrossRef
41.
Zurück zum Zitat Wang D, Shi L, Chu WC, Burwell GR, Cheng JC, Ahuja A (2012) Abnormal cerebral cortical thinning pattern in adolescent girls with idiopathic scoliosis. Neuroimage 59:935–942PubMedCrossRef Wang D, Shi L, Chu WC, Burwell GR, Cheng JC, Ahuja A (2012) Abnormal cerebral cortical thinning pattern in adolescent girls with idiopathic scoliosis. Neuroimage 59:935–942PubMedCrossRef
42.
Zurück zum Zitat Weinstein SL, Dolan LA, Cheng JC, Danielsson A, Morcuende JA (2008) Adolescent idiopathic scoliosis. Lancet 371:1527–1537PubMedCrossRef Weinstein SL, Dolan LA, Cheng JC, Danielsson A, Morcuende JA (2008) Adolescent idiopathic scoliosis. Lancet 371:1527–1537PubMedCrossRef
43.
Zurück zum Zitat Wiener-Vacher S, Mazda K (1998) Assymmetric otolith vestibulo-ocular responses in children with idiopathic scoliosis. J Pediatr 132:1028–1032PubMedCrossRef Wiener-Vacher S, Mazda K (1998) Assymmetric otolith vestibulo-ocular responses in children with idiopathic scoliosis. J Pediatr 132:1028–1032PubMedCrossRef
44.
Zurück zum Zitat Yamamoto H (1966) Experimental scoliosis in rachitic bipedal rats. Tokushima J Exp Med 13:1–34PubMed Yamamoto H (1966) Experimental scoliosis in rachitic bipedal rats. Tokushima J Exp Med 13:1–34PubMed
45.
Zurück zum Zitat Zeng W, Lui LM, Shi L, Wang D, Chu WC, Cheng JC et al (2010) Shape analysis of vestibular systems in adolescent idiopathic scoliosis using geodesic spectra. Med Image Comput Comput Assist Interv 13:538–546PubMed Zeng W, Lui LM, Shi L, Wang D, Chu WC, Cheng JC et al (2010) Shape analysis of vestibular systems in adolescent idiopathic scoliosis using geodesic spectra. Med Image Comput Comput Assist Interv 13:538–546PubMed
Metadaten
Titel
Idiopathic scoliosis and the vestibular system
verfasst von
Ammar H. Hawasli
Timothy E. Hullar
Ian G. Dorward
Publikationsdatum
01.02.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Spine Journal / Ausgabe 2/2015
Print ISSN: 0940-6719
Elektronische ISSN: 1432-0932
DOI
https://doi.org/10.1007/s00586-014-3701-4

Weitere Artikel der Ausgabe 2/2015

European Spine Journal 2/2015 Zur Ausgabe

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.