Skip to main content
Erschienen in: European Spine Journal 4/2015

01.05.2015 | Case Report

Effective treatment of delayed union of a lumbar vertebral fracture with daily administration of teriparatide in a patient with diffuse idiopathic skeletal hyperostosis

verfasst von: Takuji Matsumoto, Muneharu Ando, Shunji Sasaki

Erschienen in: European Spine Journal | Sonderheft 4/2015

Einloggen, um Zugang zu erhalten

Abstract

Introduction

We herein describe a case of delayed union of a lumbar spine fracture in a 70-year-old patient with diffuse idiopathic skeletal hyperostosis (DISH).

Clinical Course and Result

Because he decided not to undergo surgical treatment, we provided conservative treatment with teriparatide (TPTD). Union was obtained in 2 months, and no adverse events were observed during treatment. Six months after starting the TPTD, further bone formation was observed and the lumbar instability had resolved.

Conclusion

This is the first report of successful use of TPTD to treat delayed union of a spine fracture in a patient with DISH without surgical intervention.
Literatur
1.
Zurück zum Zitat Melzack R (1975) The McGill pain questionnaire: major properties and scoring methods. Pain 1:277–299CrossRefPubMed Melzack R (1975) The McGill pain questionnaire: major properties and scoring methods. Pain 1:277–299CrossRefPubMed
2.
Zurück zum Zitat Mahoney FI, Barthel DW (1965) Functional evaluation: the Barthel Index. Md State Med J 14:61–65PubMed Mahoney FI, Barthel DW (1965) Functional evaluation: the Barthel Index. Md State Med J 14:61–65PubMed
3.
Zurück zum Zitat Resnick D, Niwayama G (1976) Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Radiology 119:559–568CrossRefPubMed Resnick D, Niwayama G (1976) Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Radiology 119:559–568CrossRefPubMed
4.
Zurück zum Zitat Mader R, Verlaan JJ, Buskila D (2013) Diffuse idiopathic skeletal hyperostosis: clinical features and pathogenic mechanisms. Rev Rheumatol 9:741–750 Mader R, Verlaan JJ, Buskila D (2013) Diffuse idiopathic skeletal hyperostosis: clinical features and pathogenic mechanisms. Rev Rheumatol 9:741–750
5.
Zurück zum Zitat Westerveld LA, Verlaan JJ, Oner FC (2009) Spinal fractures in patients with ankylosing spinal disorders: a systematic review of the literature on treatment, neurological status and complications. Eur Spine J 18:145–156CrossRefPubMedCentralPubMed Westerveld LA, Verlaan JJ, Oner FC (2009) Spinal fractures in patients with ankylosing spinal disorders: a systematic review of the literature on treatment, neurological status and complications. Eur Spine J 18:145–156CrossRefPubMedCentralPubMed
6.
Zurück zum Zitat Lindsay R, Scheele WH, Neer R et al (2004) Sustained vertebral fracture risk reduction after withdrawal of teriparatide in postmenopausal women with osteoporosis. Arch Intern Med 164:2024–2030CrossRefPubMed Lindsay R, Scheele WH, Neer R et al (2004) Sustained vertebral fracture risk reduction after withdrawal of teriparatide in postmenopausal women with osteoporosis. Arch Intern Med 164:2024–2030CrossRefPubMed
7.
Zurück zum Zitat Prevrhal S, Krege JH, Chen P et al (2009) Teriparatide vertebral fracture risk reduction determined by quantitative and qualitative radiographic assessment. Curr Med Res Opin 25:921–928CrossRefPubMed Prevrhal S, Krege JH, Chen P et al (2009) Teriparatide vertebral fracture risk reduction determined by quantitative and qualitative radiographic assessment. Curr Med Res Opin 25:921–928CrossRefPubMed
8.
Zurück zum Zitat Canalis E, Giustina A, Bilezikian JP (2007) Mechanisms of anabolic therapies for osteoporosis. N Engl J Med 357:905–916CrossRefPubMed Canalis E, Giustina A, Bilezikian JP (2007) Mechanisms of anabolic therapies for osteoporosis. N Engl J Med 357:905–916CrossRefPubMed
9.
Zurück zum Zitat Gass M, Dawson-Hughes B (2006) Preventing osteoporosis-related fractures: an overview. Am J Med 119(4 Suppl 1):S3–S11CrossRefPubMed Gass M, Dawson-Hughes B (2006) Preventing osteoporosis-related fractures: an overview. Am J Med 119(4 Suppl 1):S3–S11CrossRefPubMed
11.
Zurück zum Zitat Jiang Y, Zhao JJ, Mitlak BH et al (2003) Recombinant human parathyroid hormone (1–34) [teriparatide] improves both cortical and cancellous bone structure. J Bone Miner Res 18:1932–1941CrossRefPubMed Jiang Y, Zhao JJ, Mitlak BH et al (2003) Recombinant human parathyroid hormone (1–34) [teriparatide] improves both cortical and cancellous bone structure. J Bone Miner Res 18:1932–1941CrossRefPubMed
12.
Zurück zum Zitat Lindsay R, Zhou H, Cosman F et al (2007) Effects of a one-month treatment with PTH(1–34) on bone formation on cancellous, endocortical, and periosteal surfaces of the human ilium. J Bone Miner Res 22:495–502CrossRefPubMed Lindsay R, Zhou H, Cosman F et al (2007) Effects of a one-month treatment with PTH(1–34) on bone formation on cancellous, endocortical, and periosteal surfaces of the human ilium. J Bone Miner Res 22:495–502CrossRefPubMed
13.
Zurück zum Zitat Neer RM, Arnaud CD, Zanchetta JR et al (2001) Effect of parathyroid hormone (1–34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med 344:1434–1441CrossRefPubMed Neer RM, Arnaud CD, Zanchetta JR et al (2001) Effect of parathyroid hormone (1–34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med 344:1434–1441CrossRefPubMed
14.
Zurück zum Zitat Ulivieri FM (2007) Back pain treatment in post-menopausal osteoporosis with vertebral fractures. Aging Clin Exp Res 19(3 Suppl):21–23PubMed Ulivieri FM (2007) Back pain treatment in post-menopausal osteoporosis with vertebral fractures. Aging Clin Exp Res 19(3 Suppl):21–23PubMed
15.
Zurück zum Zitat Su CH, Tu PH, Yang TC et al (2013) Comparison of the therapeutic effect of teriparatide with that of combined vertebroplasty with antiresorptive agents for the treatment of new-onset adjacent vertebral compression fracture after percutaneous vertebroplasty. J Spinal Disord Tech 26:200–206CrossRefPubMed Su CH, Tu PH, Yang TC et al (2013) Comparison of the therapeutic effect of teriparatide with that of combined vertebroplasty with antiresorptive agents for the treatment of new-onset adjacent vertebral compression fracture after percutaneous vertebroplasty. J Spinal Disord Tech 26:200–206CrossRefPubMed
16.
Zurück zum Zitat Rubery PT, Bukata SV (2010) Teriparatide may accelerate healing in delayed unions of type III odontoid fractures: a report of 3 cases. J Spinal Disord Tech 23:151–155CrossRefPubMed Rubery PT, Bukata SV (2010) Teriparatide may accelerate healing in delayed unions of type III odontoid fractures: a report of 3 cases. J Spinal Disord Tech 23:151–155CrossRefPubMed
17.
Zurück zum Zitat Ochi K, Ikari K, Naomi A et al (2013) Administration of teriparatide treatment for a challenging case of nonunion of periprosthetic fracture after total knee arthroplasty. Arch Osteoporos 8:159CrossRefPubMed Ochi K, Ikari K, Naomi A et al (2013) Administration of teriparatide treatment for a challenging case of nonunion of periprosthetic fracture after total knee arthroplasty. Arch Osteoporos 8:159CrossRefPubMed
18.
Zurück zum Zitat Giannotti S, Bottai V, Dell’Osso G et al (2013) Atrophic femoral nonunion successfully treated with teriparatide. Eur J Orthop Surg Traumatol 23:S291–S294CrossRefPubMed Giannotti S, Bottai V, Dell’Osso G et al (2013) Atrophic femoral nonunion successfully treated with teriparatide. Eur J Orthop Surg Traumatol 23:S291–S294CrossRefPubMed
19.
Zurück zum Zitat Fukuda F, Kurinomaru N, Hijioka A (2014) Weekly teriparatide for delayed unions of atypical subtrochanteric femur fractures. Biol Ther [Epub ahead of print] Fukuda F, Kurinomaru N, Hijioka A (2014) Weekly teriparatide for delayed unions of atypical subtrochanteric femur fractures. Biol Ther [Epub ahead of print]
20.
Zurück zum Zitat Tachiiri H, Okuda Y, Yamasaki T et al (2014) Weekly teriparatide administration for the treatment of delayed union: a report of two cases. Arch Osteoporos 9:179CrossRefPubMed Tachiiri H, Okuda Y, Yamasaki T et al (2014) Weekly teriparatide administration for the treatment of delayed union: a report of two cases. Arch Osteoporos 9:179CrossRefPubMed
21.
Zurück zum Zitat Chintamaneni S, Finzel K, Gruber BL (2010) Successful treatment of sternal fracture nonunion with teriparatide. Osteoporos Int 21:1059–1063CrossRefPubMed Chintamaneni S, Finzel K, Gruber BL (2010) Successful treatment of sternal fracture nonunion with teriparatide. Osteoporos Int 21:1059–1063CrossRefPubMed
22.
Zurück zum Zitat Mitani Y (2013) Effective treatment of a steroid-induced femoral neck fracture nonunion with a once-weekly administration of teriparatide in a rheumatoid patient: a case report. Arch Osteoporos 8:131CrossRefPubMedCentralPubMed Mitani Y (2013) Effective treatment of a steroid-induced femoral neck fracture nonunion with a once-weekly administration of teriparatide in a rheumatoid patient: a case report. Arch Osteoporos 8:131CrossRefPubMedCentralPubMed
23.
Zurück zum Zitat Iida Y, Takahashi H, Yokoyama Y et al (2013) Successful treatment of spine fracture for diffuse idiopathic skeletal hyperostosis with teriparatide—a report of two cases. Open J Orthop 3:278–282CrossRef Iida Y, Takahashi H, Yokoyama Y et al (2013) Successful treatment of spine fracture for diffuse idiopathic skeletal hyperostosis with teriparatide—a report of two cases. Open J Orthop 3:278–282CrossRef
Metadaten
Titel
Effective treatment of delayed union of a lumbar vertebral fracture with daily administration of teriparatide in a patient with diffuse idiopathic skeletal hyperostosis
verfasst von
Takuji Matsumoto
Muneharu Ando
Shunji Sasaki
Publikationsdatum
01.05.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Spine Journal / Ausgabe Sonderheft 4/2015
Print ISSN: 0940-6719
Elektronische ISSN: 1432-0932
DOI
https://doi.org/10.1007/s00586-014-3733-9

Weitere Artikel der Sonderheft 4/2015

European Spine Journal 4/2015 Zur Ausgabe

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.