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01.12.2011 | Original Article

HBV and HCV infection in type 2 diabetes mellitus: a survey in three diabetes units in different Italian areas

verfasst von: Valentina Soverini, Marcello Persico, Elisabetta Bugianesi, Gabriele Forlani, Federico Salamone, Mario Massarone, Vincenzo La Mura, Arianna Mazzotti, Alberto Bruno, Giulio Marchesini

Erschienen in: Acta Diabetologica | Ausgabe 4/2011

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Abstract

Viral infections and the metabolic syndrome may coexist in several individuals, due to the large prevalence of obesity and type 2 diabetes mellitus (T2DM). Antiviral therapy has changed the natural history of chronic viral hepatitis, but viral infection may remain undiagnosed in the absence of systematic screening. We determined the prevalence of HBV and/or HCV infection in an Italian cohort with T2DM (859 consecutive patients, 413 females) in three Italian centers: Turin, Bologna, and Naples. Screening for viral disease was coupled with the determination of parameters of metabolic syndrome. Fourteen patients were HBsAg-positive, 51 anti-HCV with a prevalence of genotype-1 infection in 58% of cases. Thirty cases had newly diagnosed viral markers, only one-third had already-diagnosed liver disease, 16 were being followed-up by a Liver Unit, and 9 cases had received antiviral treatment. Patients with viral markers had higher liver enzyme levels in comparison with virus-negative patients (P < 0.0001), whereas the prevalence of the metabolic syndrome was similar in the 2 groups. A positive correlation between BMI and alanine aminostransferase levels was only present in virus-negative cases, where the probability of enzyme levels above the upper limit of normal increased by 5% for unit of increase in BMI (OR: 1.05; 95% CI: 1.003–1.100, P = 0.037). In conclusion, the prevalence of HBV and HCV is non-negligible in patients with T2DM, but these cases may long remain undiagnosed. Elevated liver enzymes might be frequently disregarded in diabetes Units and ascribed to metabolic syndrome, thus excluding T2DM patients from specific disease-modifying antiviral treatment for hepatitis.

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Titel: HBV and HCV infection in type 2 diabetes mellitus: a survey in three diabetes units in different Italian areas
verfasst von: Valentina Soverini
Marcello Persico
Elisabetta Bugianesi
Gabriele Forlani
Federico Salamone
Mario Massarone
Vincenzo La Mura
Arianna Mazzotti
Alberto Bruno
Giulio Marchesini
Publikationsdatum: 01.12.2011
Verlag: Springer Milan
Erschienen in: Acta Diabetologica / Ausgabe 4/2011
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-011-0293-x

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